Effect of selenium status and supplementation with high-selenium yeast on plasma homocysteine and B vitamin concentrations in the UK elderly

Bram Bekaert, Matthew L. Cooper, Fiona R. Green, Helene McNulty, Kristina Pentieva, John M. Scott, Anne M. Molloy, Margaret P. Rayman

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Abstract

The level of plasma total homocysteine (tHcy), long known to be B vitamin dependent, has recently been shown to be inversely associated with plasma selenium (Se) concentration in human subjects. We therefore, chose to investigate the interaction between Se, tHcy and B vitamins in a double-blind, placebo-controlled trial where 501 healthy UK elderly volunteers were randomly allocated to receive 100, 200, or 300 lug Se/day as high-Se-yeast, or placebo-yeast for 6 months. Plasma Se, tHcy, folate, vitamin B-12, pyridoxal-5'-phosphate (PLP) and its catabolite, 4-pyridoxic acid. were measured in all participants at baseline and in samples from the placebo, 100 and 300 mu g Se/day groups, at follow-up. At baseline, Se was inversely correlated with tHcy but only in males (p < 0.001). Before supplementation, tHcy concentration was significantly lower in the highest compared to the lowest Se tertile in males (p < 0.05), and in females when folate concentrations were also in the top tertile (p < 0.05). The effect of folate, PLP and vitamin B-12 concentrations on plasma tHcy correlated with Se concentration at baseline. After 6 months of Se supplementation, only Se concentration had changed significantly. Supplementation with Se does not affect tHcy concentration in the UK elderly population.
LanguageEnglish
Pages1324-1333
JournalMolecular Nutrition and Food Research
Volume52
Issue number11
DOIs
Publication statusPublished - Nov 2008

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Vitamin B Complex
Homocysteine
Selenium
Yeasts
Folic Acid
Pyridoxal Phosphate
Placebos
Vitamin B 12
Pyridoxic Acid
Volunteers

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Bekaert, Bram ; Cooper, Matthew L. ; Green, Fiona R. ; McNulty, Helene ; Pentieva, Kristina ; Scott, John M. ; Molloy, Anne M. ; Rayman, Margaret P. / Effect of selenium status and supplementation with high-selenium yeast on plasma homocysteine and B vitamin concentrations in the UK elderly. In: Molecular Nutrition and Food Research. 2008 ; Vol. 52, No. 11. pp. 1324-1333.
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Effect of selenium status and supplementation with high-selenium yeast on plasma homocysteine and B vitamin concentrations in the UK elderly. / Bekaert, Bram; Cooper, Matthew L.; Green, Fiona R.; McNulty, Helene; Pentieva, Kristina; Scott, John M.; Molloy, Anne M.; Rayman, Margaret P.

In: Molecular Nutrition and Food Research, Vol. 52, No. 11, 11.2008, p. 1324-1333.

Research output: Contribution to journalArticle

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T1 - Effect of selenium status and supplementation with high-selenium yeast on plasma homocysteine and B vitamin concentrations in the UK elderly

AU - Bekaert, Bram

AU - Cooper, Matthew L.

AU - Green, Fiona R.

AU - McNulty, Helene

AU - Pentieva, Kristina

AU - Scott, John M.

AU - Molloy, Anne M.

AU - Rayman, Margaret P.

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AB - The level of plasma total homocysteine (tHcy), long known to be B vitamin dependent, has recently been shown to be inversely associated with plasma selenium (Se) concentration in human subjects. We therefore, chose to investigate the interaction between Se, tHcy and B vitamins in a double-blind, placebo-controlled trial where 501 healthy UK elderly volunteers were randomly allocated to receive 100, 200, or 300 lug Se/day as high-Se-yeast, or placebo-yeast for 6 months. Plasma Se, tHcy, folate, vitamin B-12, pyridoxal-5'-phosphate (PLP) and its catabolite, 4-pyridoxic acid. were measured in all participants at baseline and in samples from the placebo, 100 and 300 mu g Se/day groups, at follow-up. At baseline, Se was inversely correlated with tHcy but only in males (p < 0.001). Before supplementation, tHcy concentration was significantly lower in the highest compared to the lowest Se tertile in males (p < 0.05), and in females when folate concentrations were also in the top tertile (p < 0.05). The effect of folate, PLP and vitamin B-12 concentrations on plasma tHcy correlated with Se concentration at baseline. After 6 months of Se supplementation, only Se concentration had changed significantly. Supplementation with Se does not affect tHcy concentration in the UK elderly population.

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