Effect of low to moderate levels of smoking and alcohol consumption on serum immunoglobulin concentrations

SA McMillan, JP Douglas, GPR Archbold, EE McCrum, AE Evans

    Research output: Contribution to journalArticle

    36 Citations (Scopus)

    Abstract

    Aim-To determine the effect of low to moderate levels of smoking and alcohol consumption on immunoglobulin concentrations. Methods-Serum samples from 1787 subjects with approximately equal numbers in each five year group from 15 to 64 years were obtained from a large random population survey in Northern Ireland. Details were available on each subject concerning the number of units of alcohol consumed per week and the number of cigarettes smoked per day. IgG, IgM, and IgA concentrations were measured by laser nephelometry on all serum samples. Results-Low to moderate consumption of alcohol was associated with a decrease in IgG and IgM median concentrations in contrast to an increase in IgA median concentrations. The decrease in IgM and especially IgG median concentrations appeared to be related to the smoking habits of the subjects. Alcohol consumption alone was associated with increased IgA median concentrations whereas cigarette smoking alone was associated with reduced IgG median concentrations. Conclusion-Low levels of alcohol consumption and cigarette smoking influence IgG, IgM, and IgA serum concentrations. This should be borne in mind when selecting subjects for use in research and clinical settings.
    LanguageEnglish
    Pages819-822
    JournalJournal of Clinical Pathology
    Volume50
    Issue number10
    Publication statusPublished - Oct 1997

    Fingerprint

    Alcohol Drinking
    Immunoglobulins
    Immunoglobulin G
    Smoking
    Immunoglobulin A
    Immunoglobulin M
    Serum
    Nephelometry and Turbidimetry
    Northern Ireland
    Tobacco Products
    Habits
    Lasers
    Alcohols
    Research
    Population

    Cite this

    McMillan, SA., Douglas, JP., Archbold, GPR., McCrum, EE., & Evans, AE. (1997). Effect of low to moderate levels of smoking and alcohol consumption on serum immunoglobulin concentrations. Journal of Clinical Pathology, 50(10), 819-822.
    McMillan, SA ; Douglas, JP ; Archbold, GPR ; McCrum, EE ; Evans, AE. / Effect of low to moderate levels of smoking and alcohol consumption on serum immunoglobulin concentrations. In: Journal of Clinical Pathology. 1997 ; Vol. 50, No. 10. pp. 819-822.
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    McMillan, SA, Douglas, JP, Archbold, GPR, McCrum, EE & Evans, AE 1997, 'Effect of low to moderate levels of smoking and alcohol consumption on serum immunoglobulin concentrations', Journal of Clinical Pathology, vol. 50, no. 10, pp. 819-822.

    Effect of low to moderate levels of smoking and alcohol consumption on serum immunoglobulin concentrations. / McMillan, SA; Douglas, JP; Archbold, GPR; McCrum, EE; Evans, AE.

    In: Journal of Clinical Pathology, Vol. 50, No. 10, 10.1997, p. 819-822.

    Research output: Contribution to journalArticle

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    AU - Douglas, JP

    AU - Archbold, GPR

    AU - McCrum, EE

    AU - Evans, AE

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    N2 - Aim-To determine the effect of low to moderate levels of smoking and alcohol consumption on immunoglobulin concentrations. Methods-Serum samples from 1787 subjects with approximately equal numbers in each five year group from 15 to 64 years were obtained from a large random population survey in Northern Ireland. Details were available on each subject concerning the number of units of alcohol consumed per week and the number of cigarettes smoked per day. IgG, IgM, and IgA concentrations were measured by laser nephelometry on all serum samples. Results-Low to moderate consumption of alcohol was associated with a decrease in IgG and IgM median concentrations in contrast to an increase in IgA median concentrations. The decrease in IgM and especially IgG median concentrations appeared to be related to the smoking habits of the subjects. Alcohol consumption alone was associated with increased IgA median concentrations whereas cigarette smoking alone was associated with reduced IgG median concentrations. Conclusion-Low levels of alcohol consumption and cigarette smoking influence IgG, IgM, and IgA serum concentrations. This should be borne in mind when selecting subjects for use in research and clinical settings.

    AB - Aim-To determine the effect of low to moderate levels of smoking and alcohol consumption on immunoglobulin concentrations. Methods-Serum samples from 1787 subjects with approximately equal numbers in each five year group from 15 to 64 years were obtained from a large random population survey in Northern Ireland. Details were available on each subject concerning the number of units of alcohol consumed per week and the number of cigarettes smoked per day. IgG, IgM, and IgA concentrations were measured by laser nephelometry on all serum samples. Results-Low to moderate consumption of alcohol was associated with a decrease in IgG and IgM median concentrations in contrast to an increase in IgA median concentrations. The decrease in IgM and especially IgG median concentrations appeared to be related to the smoking habits of the subjects. Alcohol consumption alone was associated with increased IgA median concentrations whereas cigarette smoking alone was associated with reduced IgG median concentrations. Conclusion-Low levels of alcohol consumption and cigarette smoking influence IgG, IgM, and IgA serum concentrations. This should be borne in mind when selecting subjects for use in research and clinical settings.

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