Effect of folic acid supplementation on mood and serotonin response in healthy males

E Williams, Barbara J. Stewart-Knox, I Bradbury, I Rowland, Kristina Pentieva, A Helander, H McNulty

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Evidence suggests that low folate status may be detrimental to mood and associated with depleted cerebrospinal fluid levels of the neurotransmitter serotonin (5-hydroxytryptamine; 5-HT). A placebo-controlled trial was carried out to determine the effect of folic acid supplementation (100 mu g for 6 weeks followed by 200 mu g for a further 6 weeks) upon subjective mood (Positive and Negative Affect Schedule) and biochemical markers of mood (5-HT) in healthy males (n 23). Blood samples were obtained at baseline (week 0) and during the intervention at week 6 and week 12. Subjective mood assessments were obtained at week 0 and week 12. The results showed an increase in serum and erythrocyte folate concentrations (P=0.02 and P=0.003, respectively) and a corresponding decrease in plasma homocysteine (P=0.015) in response to the folic acid intervention. Neither subjective mood nor 5-HT levels, however, were significantly altered in response to the change in folate status. Folic acid given at physiological doses did not appear to improve the mood of healthy folate-replete individuals over a 12-week period. Further research is needed to address the effect of folic acid supplementation or of longer duration or increased dose, particularly in the face of sub-optimal folate status.
LanguageEnglish
Pages602-608
JournalBRITISH JOURNAL OF NUTRITION
Volume94
Issue number4
DOIs
Publication statusPublished - Oct 2005

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Folic Acid
Serotonin
Homocysteine
Neurotransmitter Agents
Cerebrospinal Fluid
Appointments and Schedules
Erythrocytes
Biomarkers
Placebos
Serum
Research

Cite this

Williams, E ; Stewart-Knox, Barbara J. ; Bradbury, I ; Rowland, I ; Pentieva, Kristina ; Helander, A ; McNulty, H. / Effect of folic acid supplementation on mood and serotonin response in healthy males. In: BRITISH JOURNAL OF NUTRITION. 2005 ; Vol. 94, No. 4. pp. 602-608.
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Effect of folic acid supplementation on mood and serotonin response in healthy males. / Williams, E; Stewart-Knox, Barbara J.; Bradbury, I; Rowland, I; Pentieva, Kristina; Helander, A; McNulty, H.

In: BRITISH JOURNAL OF NUTRITION, Vol. 94, No. 4, 10.2005, p. 602-608.

Research output: Contribution to journalArticle

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