Effect of B12 supplementation on renal anemia among hemodialysis patients at El-Najar hospital, Gaza strip

Abdul Rahman Mahmoud F. Nahas, Raghdaa Hamdan Al Zarzour, Asmaa Salama M. Abu Laila, Ahmed Mahmoud Tabash, Ayman Mustafa Abu Mustafa, Faten Mohamad Allyan, Abdrabbou Mohammed Elregeb, Eyad Elabed Muadi Abou Teior, Abdulkareem Mohammed Al-Shami, Mohamed Hassan Elnaem

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Introduction: Patients with end-stage renal disease (ESRD) are predisposed to nutritional deficiencies, resulting in vitamin B12 deficiency with negative hematologic consequences.

Objective: This study aimed to investigate the impact of intramuscular B12 on renal anemia among ESRD patients receiving hemodialysis (HD) at El-Najar hospital, Gaza Strip.

Patients and Methods: A case-control study conducted, which included 110 healthy controls and 110 HD patients who received B12 on a daily, weekly, and monthly basis over two months. Sociodemographics and current diseases were reported. Serum levels of serum B12, white blood cell (WBC), red blood cell (RBC), hemoglobin (Hb), mean corpuscular volume (MCV), and platelet (PLT) were recorded before and after treatment. Data analysis was conducted using SPSS.

Results: Baseline serum B12 level was significantly lower in HD patients compared to controls (362.62 ± 166.40 versus 483.36 ± 115.07 ρg/mL, P<0.001), which significantly improved after vitamin B12 treatment (639.08 ± 362.99 ρg/mL, P<0.001). Additionally, mean WBCs, RBCs, Hb, and PLT levels were significantly increased after treatment (P<0.001). Serum B12 level was positively and significantly (P<0.001) correlated with levels of WBC (r = 0.45), RBC (r = 0.43), Hb (r = 0.39) and PLT (r = 0.51), and negatively correlated with MCV (r = -0.46, P<0.001).

Conclusion: Administration of vitamin B12 improves serum B12 levels in HD patients, which was associated with increased WBCs, RBCs, Hb, and PLT levels and decreased MCV levels. Treatment by vitamin B12 can improve HD patients’ renal anemia. Future studies with larger sample sizes and prolonged follow-up are advocated.
Original languageEnglish
Number of pages5
JournalJournal of Renal Injury Prevention
Early online date28 May 2022
Publication statusPublished online - 28 May 2022


  • End stage renal disease
  • Gaza strip
  • Hemodialysis
  • Hematological indices
  • Vitamin B12


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