Effect of B-group vitamins and antioxidant vitamins on hyperhomocysteinemia: a double-blind, randomized, factorial-design, controlled trial

JV Woodside, JWG Yarnell, D McMaster, IS Young, DL Harmon, EE McCrum, CC Patterson, KF Gey, AS Whitehead, A Evans

    Research output: Contribution to journalArticle

    Abstract

    Mild hyperhomocysteinemia is accepted as a risk factor for premature cardiovascular disease. In a population with a high prevalence of cardiovascular disease, we screened a group of clinically healthy working men aged 30-49 y (n = 509) for plasma homocysteine and 5,10-methylene tetrahydrofolate reductase (MTHFR) genotype status. Those with mildly elevated homocysteine concentrations (greater than or equal to 8.34 mu mol/L) were selected for intervention. In a randomized, factorial-design. controlled trial we assessed the effects of B-group vitamins and antioxidant vitamin supplementation on homocysteine concentrations. The 132 men were randomly assigned to one of four groups: supplementation with B-group vitamins alone (1 mg folic acid, 7.2 mg pyridoxine, and 0.02 mg cyanocobalamin), antioxidant vitamins alone (150 mg ascorbic acid, 67 mg RRR-alpha-tocopherol, and 9 mg beta-carotene), B-group vitamins with antioxidant vitamins, or placebo. Intervention was double-blind. A total of 101 men completed the 8-wk intervention. When homocysteine concentrations were analyzed by group, significant (P < 0.001) decreases (32.0% and 30.0%, respectively) were observed in both groups receiving B-group vitamins either with or without antioxidants. The effect of B-group vitamins alone over 8 wk was a reduction in homocysteine concentrations of 27.9% (95% CI: 22.0%, 33.3%: P < 0.001) whereas antioxidants alone produced a nonsignificant increase of 5.1% (95% CI: -2.8%, 13.6%; P = 0.21). There was no evidence of any interaction between the two groups of vitamins. The effect of B-group vitamin supplementation seemed to depend on MTHFR genotype. Supple mentation with the B-group vitamins with or without antioxidants reduced homocysteine in the men with mildly elevated concentrations, and hence may be effective in reducing cardiovascular risk.
    Original languageEnglish
    Pages (from-to)858-866
    JournalAmerican Journal of Clinical Nutrition
    Volume67
    Issue number5
    Publication statusPublished - May 1998

    Keywords

    • n/a

    Fingerprint Dive into the research topics of 'Effect of B-group vitamins and antioxidant vitamins on hyperhomocysteinemia: a double-blind, randomized, factorial-design, controlled trial'. Together they form a unique fingerprint.

  • Cite this

    Woodside, JV., Yarnell, JWG., McMaster, D., Young, IS., Harmon, DL., McCrum, EE., Patterson, CC., Gey, KF., Whitehead, AS., & Evans, A. (1998). Effect of B-group vitamins and antioxidant vitamins on hyperhomocysteinemia: a double-blind, randomized, factorial-design, controlled trial. American Journal of Clinical Nutrition, 67(5), 858-866.