Effect of Area-Level Socioeconomic Deprivation on Risk of Cognitive Dysfunction in Older Adults

Adrian McCann, Helene McNulty, Jan Rigby, Catherine Hughes, L. Hoey, Anne M. Molloy, Conal J. Cunningham, Miriam C. Casey, Fergal Tracey, Maurice J. O'Kane, Kevin McCarroll, Mary Ward, Katie Moore, JJ Strain, Moore Adrian

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

OBJECTIVES
To investigate the relationship between area‐level deprivation and risk of cognitive dysfunction.

DESIGN
Cross‐sectional analysis.

SETTING
The Trinity, Ulster, and Department of Agriculture (TUDA) study from 2008 to 2012.

PARTICIPANTS
Community‐dwelling adults aged 74.0 ± 8.3 without dementia (N = 5,186; 67% female).

MEASUREMENTS
Adopting a cross‐jurisdictional approach, geo‐referenced address‐based information was used to map and link participants to official socioeconomic indicators of deprivation within the United Kingdom and the Republic of Ireland. Participants were assigned an individual deprivation score related to the smallest administrative area in which they lived. These scores were categorized into comparable quintiles, that were then used to integrate the datasets from both countries. Cognitive health was assessed using the Mini‐Mental State Examination (MMSE); cognitive dysfunction was defined as a MMSE score of 24 or less.

RESULTS
Approximately one‐quarter of the cohort resided within the most‐deprived districts in both countries. Greater area‐level deprivation was associated with significantly lower MMSE scores; fewer years of formal education; greater anxiety, depression, smoking and alcohol use, and obesity; and more adverse outcomes, including higher blood pressure and diabetes risk. After adjustment for relevant covariates, area deprivation was associated with significantly higher risk of cognitive dysfunction (odds ratio = 1.40, 95% confidence interval = 1.05–1.87, P = .02, for most vs least deprived).

CONCLUSION
This analysis combining data from two health systems shows that area deprivation is an independent risk factor for cognitive dysfunction in older adults. Adults living in areas of greatest socioeconomic deprivation may benefit from targeted strategies aimed at improving modifiable risk factors for dementia. Further cross‐national analysis investigating the impact of area‐ level deprivation is needed to address socioeconomic disparities and shape future policy to improve health outcomes in older adults
LanguageEnglish
Pages1269-1275
JournalJournal of the American Geriatrics Society
Volume66
Issue number7
Early online date12 Feb 2018
DOIs
Publication statusE-pub ahead of print - 12 Feb 2018

Fingerprint

Dementia
Health
Agriculture
Ireland
Anxiety
Obesity
Smoking
Odds Ratio
Alcohols
Confidence Intervals
Depression
Hypertension
Education
Cognitive Dysfunction
Datasets
United Kingdom

Keywords

  • older adults
  • cross-jurisdictional
  • geo-referencing
  • area-level deprivation
  • cognition

Cite this

McCann, Adrian ; McNulty, Helene ; Rigby, Jan ; Hughes, Catherine ; Hoey, L. ; Molloy, Anne M. ; Cunningham, Conal J. ; Casey, Miriam C. ; Tracey, Fergal ; O'Kane, Maurice J. ; McCarroll, Kevin ; Ward, Mary ; Moore, Katie ; Strain, JJ ; Adrian, Moore. / Effect of Area-Level Socioeconomic Deprivation on Risk of Cognitive Dysfunction in Older Adults. In: Journal of the American Geriatrics Society. 2018 ; Vol. 66, No. 7. pp. 1269-1275.
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abstract = "OBJECTIVESTo investigate the relationship between area‐level deprivation and risk of cognitive dysfunction.DESIGNCross‐sectional analysis.SETTINGThe Trinity, Ulster, and Department of Agriculture (TUDA) study from 2008 to 2012.PARTICIPANTSCommunity‐dwelling adults aged 74.0 ± 8.3 without dementia (N = 5,186; 67{\%} female).MEASUREMENTSAdopting a cross‐jurisdictional approach, geo‐referenced address‐based information was used to map and link participants to official socioeconomic indicators of deprivation within the United Kingdom and the Republic of Ireland. Participants were assigned an individual deprivation score related to the smallest administrative area in which they lived. These scores were categorized into comparable quintiles, that were then used to integrate the datasets from both countries. Cognitive health was assessed using the Mini‐Mental State Examination (MMSE); cognitive dysfunction was defined as a MMSE score of 24 or less.RESULTSApproximately one‐quarter of the cohort resided within the most‐deprived districts in both countries. Greater area‐level deprivation was associated with significantly lower MMSE scores; fewer years of formal education; greater anxiety, depression, smoking and alcohol use, and obesity; and more adverse outcomes, including higher blood pressure and diabetes risk. After adjustment for relevant covariates, area deprivation was associated with significantly higher risk of cognitive dysfunction (odds ratio = 1.40, 95{\%} confidence interval = 1.05–1.87, P = .02, for most vs least deprived). CONCLUSIONThis analysis combining data from two health systems shows that area deprivation is an independent risk factor for cognitive dysfunction in older adults. Adults living in areas of greatest socioeconomic deprivation may benefit from targeted strategies aimed at improving modifiable risk factors for dementia. Further cross‐national analysis investigating the impact of area‐ level deprivation is needed to address socioeconomic disparities and shape future policy to improve health outcomes in older adults",
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Effect of Area-Level Socioeconomic Deprivation on Risk of Cognitive Dysfunction in Older Adults. / McCann, Adrian; McNulty, Helene; Rigby, Jan; Hughes, Catherine; Hoey, L.; Molloy, Anne M.; Cunningham, Conal J.; Casey, Miriam C.; Tracey, Fergal; O'Kane, Maurice J.; McCarroll, Kevin; Ward, Mary; Moore, Katie; Strain, JJ; Adrian, Moore.

In: Journal of the American Geriatrics Society, Vol. 66, No. 7, 12.02.2018, p. 1269-1275.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of Area-Level Socioeconomic Deprivation on Risk of Cognitive Dysfunction in Older Adults

AU - McCann, Adrian

AU - McNulty, Helene

AU - Rigby, Jan

AU - Hughes, Catherine

AU - Hoey, L.

AU - Molloy, Anne M.

AU - Cunningham, Conal J.

AU - Casey, Miriam C.

AU - Tracey, Fergal

AU - O'Kane, Maurice J.

AU - McCarroll, Kevin

AU - Ward, Mary

AU - Moore, Katie

AU - Strain, JJ

AU - Adrian, Moore

N1 - Compliant in UIR; evidence uploaded to 'Other files'

PY - 2018/2/12

Y1 - 2018/2/12

N2 - OBJECTIVESTo investigate the relationship between area‐level deprivation and risk of cognitive dysfunction.DESIGNCross‐sectional analysis.SETTINGThe Trinity, Ulster, and Department of Agriculture (TUDA) study from 2008 to 2012.PARTICIPANTSCommunity‐dwelling adults aged 74.0 ± 8.3 without dementia (N = 5,186; 67% female).MEASUREMENTSAdopting a cross‐jurisdictional approach, geo‐referenced address‐based information was used to map and link participants to official socioeconomic indicators of deprivation within the United Kingdom and the Republic of Ireland. Participants were assigned an individual deprivation score related to the smallest administrative area in which they lived. These scores were categorized into comparable quintiles, that were then used to integrate the datasets from both countries. Cognitive health was assessed using the Mini‐Mental State Examination (MMSE); cognitive dysfunction was defined as a MMSE score of 24 or less.RESULTSApproximately one‐quarter of the cohort resided within the most‐deprived districts in both countries. Greater area‐level deprivation was associated with significantly lower MMSE scores; fewer years of formal education; greater anxiety, depression, smoking and alcohol use, and obesity; and more adverse outcomes, including higher blood pressure and diabetes risk. After adjustment for relevant covariates, area deprivation was associated with significantly higher risk of cognitive dysfunction (odds ratio = 1.40, 95% confidence interval = 1.05–1.87, P = .02, for most vs least deprived). CONCLUSIONThis analysis combining data from two health systems shows that area deprivation is an independent risk factor for cognitive dysfunction in older adults. Adults living in areas of greatest socioeconomic deprivation may benefit from targeted strategies aimed at improving modifiable risk factors for dementia. Further cross‐national analysis investigating the impact of area‐ level deprivation is needed to address socioeconomic disparities and shape future policy to improve health outcomes in older adults

AB - OBJECTIVESTo investigate the relationship between area‐level deprivation and risk of cognitive dysfunction.DESIGNCross‐sectional analysis.SETTINGThe Trinity, Ulster, and Department of Agriculture (TUDA) study from 2008 to 2012.PARTICIPANTSCommunity‐dwelling adults aged 74.0 ± 8.3 without dementia (N = 5,186; 67% female).MEASUREMENTSAdopting a cross‐jurisdictional approach, geo‐referenced address‐based information was used to map and link participants to official socioeconomic indicators of deprivation within the United Kingdom and the Republic of Ireland. Participants were assigned an individual deprivation score related to the smallest administrative area in which they lived. These scores were categorized into comparable quintiles, that were then used to integrate the datasets from both countries. Cognitive health was assessed using the Mini‐Mental State Examination (MMSE); cognitive dysfunction was defined as a MMSE score of 24 or less.RESULTSApproximately one‐quarter of the cohort resided within the most‐deprived districts in both countries. Greater area‐level deprivation was associated with significantly lower MMSE scores; fewer years of formal education; greater anxiety, depression, smoking and alcohol use, and obesity; and more adverse outcomes, including higher blood pressure and diabetes risk. After adjustment for relevant covariates, area deprivation was associated with significantly higher risk of cognitive dysfunction (odds ratio = 1.40, 95% confidence interval = 1.05–1.87, P = .02, for most vs least deprived). CONCLUSIONThis analysis combining data from two health systems shows that area deprivation is an independent risk factor for cognitive dysfunction in older adults. Adults living in areas of greatest socioeconomic deprivation may benefit from targeted strategies aimed at improving modifiable risk factors for dementia. Further cross‐national analysis investigating the impact of area‐ level deprivation is needed to address socioeconomic disparities and shape future policy to improve health outcomes in older adults

KW - older adults

KW - cross-jurisdictional

KW - geo-referencing

KW - area-level deprivation

KW - cognition

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DO - 10.1111/jgs.15258

M3 - Article

VL - 66

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EP - 1275

JO - Journal of the American Geriatrics Society

T2 - Journal of the American Geriatrics Society

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SN - 0002-8614

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