Effect of a transplantable insulinoma upon serotonin concentrations in the intestine of the rat

J. M. Conlon; C. J. Bailey; P. R. Flatt

doi:10.1136/gut.28.Suppl.213

Effect of a transplantable insulinoma upon serotonin concentrations in the intestine of the rat

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Abstract

Rapid growth of a transplantable insulinoma in rats over a 14 day period results in hyperphagia together with a selective increase in the weight and enteroglucagon (GLI) concentration of the small intestine. Measurement of serotonin concentrations by an HPLC/fluorometric method demonstrated an increase in blood (91 %; p < 0·05) and in extracts of colon (22 %; p < 0·05) but no change in extracts of the small intestine and caecum. The data support the hypothesis that the rise in enteroglucagon is related directly to the growth of the small intestine and is not a non-specific effect of hyperphagia.

Original language	English
Pages (from-to)	213-216
Number of pages	4
Journal	GUT
Volume	28
Issue number	SUPPL.1
DOIs	https://doi.org/10.1136/gut.28.Suppl.213
Publication status	Published (in print/issue) - 1987

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10.1136/gut.28.Suppl.213

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AU - Bailey, C. J.

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AB - Rapid growth of a transplantable insulinoma in rats over a 14 day period results in hyperphagia together with a selective increase in the weight and enteroglucagon (GLI) concentration of the small intestine. Measurement of serotonin concentrations by an HPLC/fluorometric method demonstrated an increase in blood (91 %; p < 0·05) and in extracts of colon (22 %; p < 0·05) but no change in extracts of the small intestine and caecum. The data support the hypothesis that the rise in enteroglucagon is related directly to the growth of the small intestine and is not a non-specific effect of hyperphagia.

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Effect of a transplantable insulinoma upon serotonin concentrations in the intestine of the rat

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