Dual rotation centrifugal electrospinning: a novel approach to engineer multi-directional and layered fiber composite matrices

Li Wang, Baolin Wang, Zeeshan Ahmad, Jing Song Li, Ming Wei Chang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In this study, a dual rotation centrifugal electrospinning system (DRCES) is designed, developed, and used to prepare medicated fabrics. Through simultaneous rotation of both spinneret and collector, multi-directional blended fiber matrices (PVP and TPU) were deposited directly on the rotating collector. To detail the process, key stages of the centrifugal electrospinning process are elaborated, and the influence of gas infusion and collector rotation speed on resulting fiber morphologies was explored. Multi-directional fibrous structures show in vitro biocompatibility (fibroblast). Regulation of drug release rate was achieved using polymer composition and filament alignment. This study demonstrates a rapid fabrication method (~ 50 g/h) to engineer layered fibrous structures using DRCES, which provides a foundation for preparing complex drug matrices (single and multi-directional) for tailored active component release.

Original languageEnglish
Pages (from-to)204-214
Number of pages11
JournalDrug Delivery and Translational Research
Volume9
Issue number1
Early online date19 Oct 2018
DOIs
Publication statusPublished - 15 Feb 2019

Keywords

  • Centrifugal electrospinning
  • Composite fiber
  • Dual rotation
  • Layers
  • Multi-directional

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