Drug loaded implantable devices to treat cardiovascular disease

Masoud Adhami, Niamh K. Martin, Ciara Maguire, Aaron J. Courtenay, Ryan F. Donnelly, Juan Domínguez-Robles, Eneko Larrañeta

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)
6 Downloads (Pure)

Abstract

INTRODUCTION: It is widely acknowledged that cardiovascular diseases (CVDs) continue to be the leading cause of death globally. Furthermore, CVDs are the leading cause of diminished quality of life for patients, frequently as a result of their progressive deterioration. Medical implants that release drugs into the body are active implants that do more than just provide mechanical support; they also have a therapeutic role. Primarily, this is achieved through the controlled release of active pharmaceutical ingredients (API) at the implementation site.

AREAS COVERED: In this review, the authors discuss drug-eluting stents, drug-eluting vascular grafts, and drug-eluting cardiac patches with the aim of providing a broad overview of the three most common types of cardiac implant.

EXPERT OPINION: Drug eluting implants are an ideal alternative to traditional drug delivery because they allow for accurate drug release, local drug delivery to the target tissue, and minimize the adverse side effects associated with systemic administration. Despite the fact that there are still challenges that need to be addressed, the ever-evolving new technologies are making the fabrication of drug-eluting implants a rewarding therapeutic endeavor with the possibility for even greater advances.

Original languageEnglish
Pages (from-to)1-16
Number of pages16
JournalExpert Opinion on Drug Delivery
Volume20
Issue number4
Early online date28 Mar 2023
DOIs
Publication statusPublished online - 28 Mar 2023

Bibliographical note

Funding Information:
J. Domínguez Robles acknowledges financial support from the Ramón y Cajal grant RYC-2021-034357-I funded by MCIN/AEI/10.13039/501100011033 and by the “European Union NextGenerationEU/PRTR”.

Publisher Copyright:
© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

Keywords

  • Cardiovascular disease
  • Implantable devices
  • cardiac patches
  • Cardiovascular stents
  • Vascular grafts
  • implantable devices
  • vascular grafts
  • cardiovascular stents

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