Dramatis Personae in β-Cell Mass Regulation: Enter SerpinB1

Andrei I. Tarasov; Patrik Rorsman

doi:10.1016/j.cmet.2015.12.011

Dramatis Personae in β-Cell Mass Regulation: Enter SerpinB1

Andrei I. Tarasov, Patrik Rorsman

Research output: Contribution to journal › Short survey › peer-review

5 Citations (Scopus)

Abstract

How is β-cell mass adjusted to changes in the functional insulin requirements? The answer to this question is central to the understanding of the causes and (potentially) the therapy of type 2 diabetes. In this issue of Cell Metabolism, El Ouaamari et al. (2016) report that increased production of the protease inhibitor SerpinB1 in the liver links insulin resistance to stimulation of β-cell proliferation.

Original language	English
Pages (from-to)	8-10
Number of pages	3
Journal	Cell Metabolism
Volume	23
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2015.12.011
Publication status	Published (in print/issue) - 12 Jan 2016

Funding

We thank Dr. Anne Clark and Professor Frances M. Ashcroft for discussions. P.R. and A.I.T. are supported by the Wellcome Trust, DiabetesUK, the National Institute for Health Research (NIHR), the Swedish Research Council, and the Knut and Alice Wallenberg’s Stiftelse.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cmet.2015.12.011

Cite this

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title = "Dramatis Personae in β-Cell Mass Regulation: Enter SerpinB1",

abstract = "How is β-cell mass adjusted to changes in the functional insulin requirements? The answer to this question is central to the understanding of the causes and (potentially) the therapy of type 2 diabetes. In this issue of Cell Metabolism, El Ouaamari et al. (2016) report that increased production of the protease inhibitor SerpinB1 in the liver links insulin resistance to stimulation of β-cell proliferation.",

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T2 - Enter SerpinB1

AU - Tarasov, Andrei I.

AU - Rorsman, Patrik

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Y1 - 2016/1/12

N2 - How is β-cell mass adjusted to changes in the functional insulin requirements? The answer to this question is central to the understanding of the causes and (potentially) the therapy of type 2 diabetes. In this issue of Cell Metabolism, El Ouaamari et al. (2016) report that increased production of the protease inhibitor SerpinB1 in the liver links insulin resistance to stimulation of β-cell proliferation.

AB - How is β-cell mass adjusted to changes in the functional insulin requirements? The answer to this question is central to the understanding of the causes and (potentially) the therapy of type 2 diabetes. In this issue of Cell Metabolism, El Ouaamari et al. (2016) report that increased production of the protease inhibitor SerpinB1 in the liver links insulin resistance to stimulation of β-cell proliferation.

UR - https://www.scopus.com/pages/publications/84955259106

U2 - 10.1016/j.cmet.2015.12.011

DO - 10.1016/j.cmet.2015.12.011

M3 - Short survey

C2 - 26771113

AN - SCOPUS:84955259106

SN - 1550-4131

VL - 23

SP - 8

EP - 10

JO - Cell Metabolism

JF - Cell Metabolism

IS - 1

ER -

Dramatis Personae in β-Cell Mass Regulation: Enter SerpinB1

Abstract

Funding

UN SDGs

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