Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation

Amy V. Pointon, Tracy M. Walker, Kate M. Phillips, Jinli Luo, Joan Riley, Shu-Dong Zhang, Joel D. Parry, Jonathan J. Lyon, Emma L. Marczylo, Timothy W. Gant

Research output: Contribution to journalArticlepeer-review

97 Citations (Scopus)
39 Downloads (Pure)
Original languageEnglish
Pages (from-to)e12733
JournalPLoS ONE
Issue number9
Publication statusPublished (in print/issue) - 2010


  • Doxorubicin
  • Myocardial Electron Transport Chain Genes
  • ATP Loss
  • Caspase 3 Activation
  • cardiotoxicity

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