Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation

Amy V. Pointon, Tracy M. Walker, Kate M. Phillips, Jinli Luo, Joan Riley, Shu-Dong Zhang, Joel D. Parry, Jonathan J. Lyon, Emma L. Marczylo, Timothy W. Gant

Research output: Contribution to journalArticle

78 Citations (Scopus)
1 Downloads (Pure)
Original languageEnglish
Pages (from-to)e12733
JournalPLoS ONE
Volume5
Issue number9
DOIs
Publication statusPublished - 2010

Keywords

  • Doxorubicin
  • Myocardial Electron Transport Chain Genes
  • ATP Loss
  • Caspase 3 Activation
  • cardiotoxicity

Cite this

Pointon, A. V., Walker, T. M., Phillips, K. M., Luo, J., Riley, J., Zhang, S-D., Parry, J. D., Lyon, J. J., Marczylo, E. L., & Gant, T. W. (2010). Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation. PLoS ONE, 5(9), e12733. https://doi.org/10.1371/journal.pone.0012733