Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation

Amy V. Pointon; Tracy M. Walker; Kate M. Phillips; Jinli Luo; Joan Riley; Shu-Dong Zhang; Joel D. Parry; Jonathan J. Lyon; Emma L. Marczylo; Timothy W. Gant

doi:10.1371/journal.pone.0012733

Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation

Amy V. Pointon, Tracy M. Walker, Kate M. Phillips, Jinli Luo, Joan Riley, Shu-Dong Zhang, Joel D. Parry, Jonathan J. Lyon, Emma L. Marczylo, Timothy W. Gant

Faculty Of Life & Health Sciences

Research output: Contribution to journal › Article › peer-review

86 Citations (Scopus)

18 Downloads (Pure)

Original language	English
Pages (from-to)	e12733
Journal	PLoS ONE
Volume	5
Issue number	9
DOIs	https://doi.org/10.1371/journal.pone.0012733
Publication status	Published - 2010

Keywords

Doxorubicin
Myocardial Electron Transport Chain Genes
ATP Loss
Caspase 3 Activation
cardiotoxicity

Access to Document

10.1371/journal.pone.0012733

2010-0915-plos-one-Doxorubicin-journalFinal published version, 1.56 MB

Cite this

@article{bbf67b803f2241ce9c91d3c7c910a829,

title = "Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation",

keywords = "Doxorubicin, Myocardial Electron Transport Chain Genes, ATP Loss, Caspase 3 Activation, cardiotoxicity",

author = "Pointon, {Amy V.} and Walker, {Tracy M.} and Phillips, {Kate M.} and Jinli Luo and Joan Riley and Shu-Dong Zhang and Parry, {Joel D.} and Lyon, {Jonathan J.} and Marczylo, {Emma L.} and Gant, {Timothy W.}",

year = "2010",

doi = "10.1371/journal.pone.0012733",

language = "English",

volume = "5",

pages = "e12733",

journal = "PLoS ONE",

issn = "1932-6203",

publisher = "PLoS",

number = "9",

}

TY - JOUR

T1 - Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation

AU - Pointon, Amy V.

AU - Walker, Tracy M.

AU - Phillips, Kate M.

AU - Luo, Jinli

AU - Riley, Joan

AU - Zhang, Shu-Dong

AU - Parry, Joel D.

AU - Lyon, Jonathan J.

AU - Marczylo, Emma L.

AU - Gant, Timothy W.

PY - 2010

Y1 - 2010

KW - Doxorubicin

KW - Myocardial Electron Transport Chain Genes

KW - ATP Loss

KW - Caspase 3 Activation

KW - cardiotoxicity

U2 - 10.1371/journal.pone.0012733

DO - 10.1371/journal.pone.0012733

M3 - Article

VL - 5

SP - e12733

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 9

ER -