Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation

Amy V. Pointon; Tracy M. Walker; Kate M. Phillips; Jinli Luo; Joan Riley; Shu-Dong Zhang; Joel D. Parry; Jonathan J. Lyon; Emma L. Marczylo; Timothy W. Gant

doi:10.1371/journal.pone.0012733

Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation

Amy V. Pointon, Tracy M. Walker, Kate M. Phillips, Jinli Luo, Joan Riley, Shu-Dong Zhang, Joel D. Parry, Jonathan J. Lyon, Emma L. Marczylo, Timothy W. Gant

Faculty Of Life & Health Sciences

Research output: Contribution to journal › Article

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Original language	English
Pages (from-to)	e12733
Journal	PLoS ONE
Volume	5
Issue number	9
DOIs	https://doi.org/10.1371/journal.pone.0012733
Publication status	Published - 2010

Keywords

Doxorubicin
Myocardial Electron Transport Chain Genes
ATP Loss
Caspase 3 Activation
cardiotoxicity

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10.1371/journal.pone.0012733

2010-0915-plos-one-Doxorubicin-journalFinal published version, 1.56 MB

Cite this

Pointon, A. V., Walker, T. M., Phillips, K. M., Luo, J., Riley, J., Zhang, S-D., Parry, J. D., Lyon, J. J., Marczylo, E. L., & Gant, T. W. (2010). Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation. PLoS ONE, 5(9), e12733. https://doi.org/10.1371/journal.pone.0012733

Pointon, Amy V. ; Walker, Tracy M. ; Phillips, Kate M. ; Luo, Jinli ; Riley, Joan ; Zhang, Shu-Dong ; Parry, Joel D. ; Lyon, Jonathan J. ; Marczylo, Emma L. ; Gant, Timothy W. / Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation. In: PLoS ONE. 2010 ; Vol. 5, No. 9. pp. e12733.

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author = "Pointon, {Amy V.} and Walker, {Tracy M.} and Phillips, {Kate M.} and Jinli Luo and Joan Riley and Shu-Dong Zhang and Parry, {Joel D.} and Lyon, {Jonathan J.} and Marczylo, {Emma L.} and Gant, {Timothy W.}",

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Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation. / Pointon, Amy V.; Walker, Tracy M.; Phillips, Kate M.; Luo, Jinli; Riley, Joan; Zhang, Shu-Dong; Parry, Joel D.; Lyon, Jonathan J.; Marczylo, Emma L.; Gant, Timothy W.

In: PLoS ONE, Vol. 5, No. 9, 2010, p. e12733.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation

AU - Pointon, Amy V.

AU - Walker, Tracy M.

AU - Phillips, Kate M.

AU - Luo, Jinli

AU - Riley, Joan

AU - Zhang, Shu-Dong

AU - Parry, Joel D.

AU - Lyon, Jonathan J.

AU - Marczylo, Emma L.

AU - Gant, Timothy W.

PY - 2010

Y1 - 2010

KW - Doxorubicin

KW - Myocardial Electron Transport Chain Genes

KW - ATP Loss

KW - Caspase 3 Activation

KW - cardiotoxicity

U2 - 10.1371/journal.pone.0012733

DO - 10.1371/journal.pone.0012733

M3 - Article

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SP - e12733

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

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