Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation

Amy V. Pointon, Tracy M. Walker, Kate M. Phillips, Jinli Luo, Joan Riley, Shu-Dong Zhang, Joel D. Parry, Jonathan J. Lyon, Emma L. Marczylo, Timothy W. Gant

Research output: Contribution to journal › Article

74 Citations (Scopus)
LanguageEnglish
Pagese12733
JournalPLoS ONE
Volume5
Issue number9
DOIs
Publication statusPublished - 2010

Keywords

  • Doxorubicin
  • Myocardial Electron Transport Chain Genes
  • ATP Loss
  • Caspase 3 Activation
  • cardiotoxicity

Cite this

Pointon, Amy V. ; Walker, Tracy M. ; Phillips, Kate M. ; Luo, Jinli ; Riley, Joan ; Zhang, Shu-Dong ; Parry, Joel D. ; Lyon, Jonathan J. ; Marczylo, Emma L. ; Gant, Timothy W. / Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation. In: PLoS ONE. 2010 ; Vol. 5, No. 9. pp. e12733.
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title = "Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation",
keywords = "Doxorubicin, Myocardial Electron Transport Chain Genes, ATP Loss, Caspase 3 Activation, cardiotoxicity",
author = "Pointon, {Amy V.} and Walker, {Tracy M.} and Phillips, {Kate M.} and Jinli Luo and Joan Riley and Shu-Dong Zhang and Parry, {Joel D.} and Lyon, {Jonathan J.} and Marczylo, {Emma L.} and Gant, {Timothy W.}",
year = "2010",
doi = "10.1371/journal.pone.0012733",
language = "English",
volume = "5",
pages = "e12733",
journal = "PLoS ONE",
issn = "1932-6203",
number = "9",

}

Pointon, AV, Walker, TM, Phillips, KM, Luo, J, Riley, J, Zhang, S-D, Parry, JD, Lyon, JJ, Marczylo, EL & Gant, TW 2010, 'Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation', PLoS ONE, vol. 5, no. 9, pp. e12733. https://doi.org/10.1371/journal.pone.0012733

Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation. / Pointon, Amy V.; Walker, Tracy M.; Phillips, Kate M.; Luo, Jinli; Riley, Joan; Zhang, Shu-Dong; Parry, Joel D.; Lyon, Jonathan J.; Marczylo, Emma L.; Gant, Timothy W.

In: PLoS ONE, Vol. 5, No. 9, 2010, p. e12733.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation

AU - Pointon, Amy V.

AU - Walker, Tracy M.

AU - Phillips, Kate M.

AU - Luo, Jinli

AU - Riley, Joan

AU - Zhang, Shu-Dong

AU - Parry, Joel D.

AU - Lyon, Jonathan J.

AU - Marczylo, Emma L.

AU - Gant, Timothy W.

PY - 2010

Y1 - 2010

KW - Doxorubicin

KW - Myocardial Electron Transport Chain Genes

KW - ATP Loss

KW - Caspase 3 Activation

KW - cardiotoxicity

U2 - 10.1371/journal.pone.0012733

DO - 10.1371/journal.pone.0012733

M3 - Article

VL - 5

SP - e12733

JO - PLoS ONE

T2 - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 9

ER -

Pointon AV, Walker TM, Phillips KM, Luo J, Riley J, Zhang S-D et al. Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation. PLoS ONE. 2010;5(9):e12733. https://doi.org/10.1371/journal.pone.0012733

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