Does soy protein affect circulating levels of unbound IGF-1?

Mark Messina, PJ Magee

Research output: Contribution to journalArticle

Abstract

Introduction Despite the enormous amount of research that has been conducted on the role of soyfoods in the prevention and treatment of chronic disease, the mechanisms by which soy exerts its physiological effects are not fully understood. The clinical data show that neither soyfoods nor soy protein nor isoflavones affect circulating levels of reproductive hormones in men or women. However, some research suggests that soy protein, but not isoflavones, affects insulin-like growth factor I (IGF-1). Methods Since IGF-1 may have wide-ranging physiological effects, we sought to determine the effect of soy protein on IGF-1 and its major binding protein insulin-like growth factor-binding protein (IGFBP-3). Six clinical studies were identified that compared soy protein with a control protein, albeit only two studies measured IGFBP-3 in addition to IGF-1. Results Although the data are difficult to interpret because of the different experimental designs employed, there is some evidence that large amounts of soy protein (>25 g/day) modestly increase IGF-1 levels above levels observed with the control protein. Conclusion The clinical data suggest that a decision to incorporate soy into the diet should not be based on its possible effects on IGF-1.
LanguageEnglish
JournalEuropean Journal of Nutrition
Early online date22 Apr 2017
DOIs
Publication statusE-pub ahead of print - 22 Apr 2017

Fingerprint

Soybean Proteins
Insulin-Like Growth Factor I
Insulin-Like Growth Factor Binding Protein 3
Isoflavones
Research
Carrier Proteins
Proteins
Chronic Disease
Research Design
Hormones
Diet

Keywords

  • soy
  • isoflavones
  • clinical trials
  • cancer

Cite this

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title = "Does soy protein affect circulating levels of unbound IGF-1?",
abstract = "Introduction Despite the enormous amount of research that has been conducted on the role of soyfoods in the prevention and treatment of chronic disease, the mechanisms by which soy exerts its physiological effects are not fully understood. The clinical data show that neither soyfoods nor soy protein nor isoflavones affect circulating levels of reproductive hormones in men or women. However, some research suggests that soy protein, but not isoflavones, affects insulin-like growth factor I (IGF-1). Methods Since IGF-1 may have wide-ranging physiological effects, we sought to determine the effect of soy protein on IGF-1 and its major binding protein insulin-like growth factor-binding protein (IGFBP-3). Six clinical studies were identified that compared soy protein with a control protein, albeit only two studies measured IGFBP-3 in addition to IGF-1. Results Although the data are difficult to interpret because of the different experimental designs employed, there is some evidence that large amounts of soy protein (>25 g/day) modestly increase IGF-1 levels above levels observed with the control protein. Conclusion The clinical data suggest that a decision to incorporate soy into the diet should not be based on its possible effects on IGF-1.",
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Does soy protein affect circulating levels of unbound IGF-1? / Messina, Mark; Magee, PJ.

In: European Journal of Nutrition, 22.04.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Does soy protein affect circulating levels of unbound IGF-1?

AU - Messina, Mark

AU - Magee, PJ

PY - 2017/4/22

Y1 - 2017/4/22

N2 - Introduction Despite the enormous amount of research that has been conducted on the role of soyfoods in the prevention and treatment of chronic disease, the mechanisms by which soy exerts its physiological effects are not fully understood. The clinical data show that neither soyfoods nor soy protein nor isoflavones affect circulating levels of reproductive hormones in men or women. However, some research suggests that soy protein, but not isoflavones, affects insulin-like growth factor I (IGF-1). Methods Since IGF-1 may have wide-ranging physiological effects, we sought to determine the effect of soy protein on IGF-1 and its major binding protein insulin-like growth factor-binding protein (IGFBP-3). Six clinical studies were identified that compared soy protein with a control protein, albeit only two studies measured IGFBP-3 in addition to IGF-1. Results Although the data are difficult to interpret because of the different experimental designs employed, there is some evidence that large amounts of soy protein (>25 g/day) modestly increase IGF-1 levels above levels observed with the control protein. Conclusion The clinical data suggest that a decision to incorporate soy into the diet should not be based on its possible effects on IGF-1.

AB - Introduction Despite the enormous amount of research that has been conducted on the role of soyfoods in the prevention and treatment of chronic disease, the mechanisms by which soy exerts its physiological effects are not fully understood. The clinical data show that neither soyfoods nor soy protein nor isoflavones affect circulating levels of reproductive hormones in men or women. However, some research suggests that soy protein, but not isoflavones, affects insulin-like growth factor I (IGF-1). Methods Since IGF-1 may have wide-ranging physiological effects, we sought to determine the effect of soy protein on IGF-1 and its major binding protein insulin-like growth factor-binding protein (IGFBP-3). Six clinical studies were identified that compared soy protein with a control protein, albeit only two studies measured IGFBP-3 in addition to IGF-1. Results Although the data are difficult to interpret because of the different experimental designs employed, there is some evidence that large amounts of soy protein (>25 g/day) modestly increase IGF-1 levels above levels observed with the control protein. Conclusion The clinical data suggest that a decision to incorporate soy into the diet should not be based on its possible effects on IGF-1.

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SN - 1436-6207

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