Docosahexaenoic acid reduces in vitro invasion of renal cell carcinoma by elevated levels of tissue inhibitor of metalloproteinase-1

AJ McCabe, JMW Wallace, WS Gilmore, H McGlynn, JJ Strain

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We demonstrate in this study that the n-3 polyunsaturated fatty acids derived from fish oil, namely, eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA), can increase levels of tissue inhibitors of metal loprotemase-1 (TIMP-1) in the renal cell carcinoma cell line caki-1 by 26% and 17.42% respectively. The result of this elevation in TIMP-1 levels is a reduction of 48.48% in caki-1 invasion through the basement membrane component matrigel when cells are treated with DHA. By inhibition of 2-series prostaglandin production, a similar increase in TIMP-1 was observed in caki-1 cells. We conclude that the polyunstaurated fatty acid DHA, a component of fish oil, is capable of significantly reducing the invasive profile of renal cell carcinoma, and that this reduction is regulated by levels of 2-series prostaglandin production. (C) 2005 Elsevier Inc. All rights reserved.
LanguageEnglish
Pages17-22
JournalJournal of Nutritional Biochemistry
Volume16
Issue number1
DOIs
Publication statusPublished - Jan 2005

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Tissue Inhibitor of Metalloproteinase-1
Docosahexaenoic Acids
Renal Cell Carcinoma
Fish Oils
Metals
Prostaglandins
Eicosapentaenoic Acid
Omega-3 Fatty Acids
Basement Membrane
Fatty Acids
Cell Line
In Vitro Techniques

Cite this

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title = "Docosahexaenoic acid reduces in vitro invasion of renal cell carcinoma by elevated levels of tissue inhibitor of metalloproteinase-1",
abstract = "We demonstrate in this study that the n-3 polyunsaturated fatty acids derived from fish oil, namely, eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA), can increase levels of tissue inhibitors of metal loprotemase-1 (TIMP-1) in the renal cell carcinoma cell line caki-1 by 26{\%} and 17.42{\%} respectively. The result of this elevation in TIMP-1 levels is a reduction of 48.48{\%} in caki-1 invasion through the basement membrane component matrigel when cells are treated with DHA. By inhibition of 2-series prostaglandin production, a similar increase in TIMP-1 was observed in caki-1 cells. We conclude that the polyunstaurated fatty acid DHA, a component of fish oil, is capable of significantly reducing the invasive profile of renal cell carcinoma, and that this reduction is regulated by levels of 2-series prostaglandin production. (C) 2005 Elsevier Inc. All rights reserved.",
author = "AJ McCabe and JMW Wallace and WS Gilmore and H McGlynn and JJ Strain",
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Docosahexaenoic acid reduces in vitro invasion of renal cell carcinoma by elevated levels of tissue inhibitor of metalloproteinase-1. / McCabe, AJ; Wallace, JMW; Gilmore, WS; McGlynn, H; Strain, JJ.

In: Journal of Nutritional Biochemistry, Vol. 16, No. 1, 01.2005, p. 17-22.

Research output: Contribution to journalArticle

TY - JOUR

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AU - McCabe, AJ

AU - Wallace, JMW

AU - Gilmore, WS

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AU - Strain, JJ

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AB - We demonstrate in this study that the n-3 polyunsaturated fatty acids derived from fish oil, namely, eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA), can increase levels of tissue inhibitors of metal loprotemase-1 (TIMP-1) in the renal cell carcinoma cell line caki-1 by 26% and 17.42% respectively. The result of this elevation in TIMP-1 levels is a reduction of 48.48% in caki-1 invasion through the basement membrane component matrigel when cells are treated with DHA. By inhibition of 2-series prostaglandin production, a similar increase in TIMP-1 was observed in caki-1 cells. We conclude that the polyunstaurated fatty acid DHA, a component of fish oil, is capable of significantly reducing the invasive profile of renal cell carcinoma, and that this reduction is regulated by levels of 2-series prostaglandin production. (C) 2005 Elsevier Inc. All rights reserved.

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