Do polymorphisms of apoB, LPL or apoE affect the hypocholesterolemic response to weight loss?

F Kee, IS Young, O Poirier, D McMaster, E McCrum, J McGeough, CC Patterson, J Dallongeville, F Cambien, AE Evans

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    Abstract

    To assess whether there is a differential hypocholesterolemic response to weight loss for subjects carrying polymorphisms of the apolipoprotein B and other genes. A before and after comparison of lipid parameters following a calorie controlled diet for an intervention period of 12 weeks. A lipid clinic based in a large teaching hospital. The difference in slope coefficients relating the percentage change in lipid parameters to the change in body weight (adjusted for age, gender and initial body mass index (BMI)), for genotype subgroups defined by polymorphisms of the 5'VNTR apoB gene, two mutations of the LPL gene and ApoE. One hundred and forty six subjects completed the intervention diet. While, on average, the intervention was successful (mean weight loss 3.9%), there was no statistically significant difference in the slope coefficients relating lipid change to weight loss for most of the genotypes tested. The slope difference for long versus short 5'VNTR alleles of the apoB gene was 0.445 (-1.307, 2.198) for apolipoprotein B and -0.104 (-1.486, 1.278) for total cholesterol. However, subjects carrying at least one epsilon4 allele were significantly hypo-responsive to weight loss, difference in slope coefficients - 1.087 (-2.09, -0.084) and -1.320 (-2.589, 0.051) for total cholesterol and apoB, respectively. Although, this study is one of the largest of its kind, it has not replicated the findings of other smaller studies. These findings do not provide support for the use of genotype-targeted dietary advice in routine practice. (C) 2000 Elsevier Science Ireland Ltd. hll rights reserved.
    LanguageEnglish
    Pages119-128
    JournalAtherosclerosis
    Volume153
    Issue number1
    Publication statusPublished - Nov 2000

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    Apolipoproteins B
    Apolipoproteins E
    Weight Loss
    Lipids
    Genotype
    Genes
    Alleles
    Cholesterol
    Diet
    Body Weight Changes
    Teaching Hospitals
    Body Mass Index
    Mutation

    Cite this

    Kee, F., Young, IS., Poirier, O., McMaster, D., McCrum, E., McGeough, J., ... Evans, AE. (2000). Do polymorphisms of apoB, LPL or apoE affect the hypocholesterolemic response to weight loss? Atherosclerosis, 153(1), 119-128.
    Kee, F ; Young, IS ; Poirier, O ; McMaster, D ; McCrum, E ; McGeough, J ; Patterson, CC ; Dallongeville, J ; Cambien, F ; Evans, AE. / Do polymorphisms of apoB, LPL or apoE affect the hypocholesterolemic response to weight loss?. In: Atherosclerosis. 2000 ; Vol. 153, No. 1. pp. 119-128.
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    abstract = "To assess whether there is a differential hypocholesterolemic response to weight loss for subjects carrying polymorphisms of the apolipoprotein B and other genes. A before and after comparison of lipid parameters following a calorie controlled diet for an intervention period of 12 weeks. A lipid clinic based in a large teaching hospital. The difference in slope coefficients relating the percentage change in lipid parameters to the change in body weight (adjusted for age, gender and initial body mass index (BMI)), for genotype subgroups defined by polymorphisms of the 5'VNTR apoB gene, two mutations of the LPL gene and ApoE. One hundred and forty six subjects completed the intervention diet. While, on average, the intervention was successful (mean weight loss 3.9{\%}), there was no statistically significant difference in the slope coefficients relating lipid change to weight loss for most of the genotypes tested. The slope difference for long versus short 5'VNTR alleles of the apoB gene was 0.445 (-1.307, 2.198) for apolipoprotein B and -0.104 (-1.486, 1.278) for total cholesterol. However, subjects carrying at least one epsilon4 allele were significantly hypo-responsive to weight loss, difference in slope coefficients - 1.087 (-2.09, -0.084) and -1.320 (-2.589, 0.051) for total cholesterol and apoB, respectively. Although, this study is one of the largest of its kind, it has not replicated the findings of other smaller studies. These findings do not provide support for the use of genotype-targeted dietary advice in routine practice. (C) 2000 Elsevier Science Ireland Ltd. hll rights reserved.",
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    Kee, F, Young, IS, Poirier, O, McMaster, D, McCrum, E, McGeough, J, Patterson, CC, Dallongeville, J, Cambien, F & Evans, AE 2000, 'Do polymorphisms of apoB, LPL or apoE affect the hypocholesterolemic response to weight loss?', Atherosclerosis, vol. 153, no. 1, pp. 119-128.

    Do polymorphisms of apoB, LPL or apoE affect the hypocholesterolemic response to weight loss? / Kee, F; Young, IS; Poirier, O; McMaster, D; McCrum, E; McGeough, J; Patterson, CC; Dallongeville, J; Cambien, F; Evans, AE.

    In: Atherosclerosis, Vol. 153, No. 1, 11.2000, p. 119-128.

    Research output: Contribution to journalArticle

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    AU - McGeough, J

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    AU - Dallongeville, J

    AU - Cambien, F

    AU - Evans, AE

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    N2 - To assess whether there is a differential hypocholesterolemic response to weight loss for subjects carrying polymorphisms of the apolipoprotein B and other genes. A before and after comparison of lipid parameters following a calorie controlled diet for an intervention period of 12 weeks. A lipid clinic based in a large teaching hospital. The difference in slope coefficients relating the percentage change in lipid parameters to the change in body weight (adjusted for age, gender and initial body mass index (BMI)), for genotype subgroups defined by polymorphisms of the 5'VNTR apoB gene, two mutations of the LPL gene and ApoE. One hundred and forty six subjects completed the intervention diet. While, on average, the intervention was successful (mean weight loss 3.9%), there was no statistically significant difference in the slope coefficients relating lipid change to weight loss for most of the genotypes tested. The slope difference for long versus short 5'VNTR alleles of the apoB gene was 0.445 (-1.307, 2.198) for apolipoprotein B and -0.104 (-1.486, 1.278) for total cholesterol. However, subjects carrying at least one epsilon4 allele were significantly hypo-responsive to weight loss, difference in slope coefficients - 1.087 (-2.09, -0.084) and -1.320 (-2.589, 0.051) for total cholesterol and apoB, respectively. Although, this study is one of the largest of its kind, it has not replicated the findings of other smaller studies. These findings do not provide support for the use of genotype-targeted dietary advice in routine practice. (C) 2000 Elsevier Science Ireland Ltd. hll rights reserved.

    AB - To assess whether there is a differential hypocholesterolemic response to weight loss for subjects carrying polymorphisms of the apolipoprotein B and other genes. A before and after comparison of lipid parameters following a calorie controlled diet for an intervention period of 12 weeks. A lipid clinic based in a large teaching hospital. The difference in slope coefficients relating the percentage change in lipid parameters to the change in body weight (adjusted for age, gender and initial body mass index (BMI)), for genotype subgroups defined by polymorphisms of the 5'VNTR apoB gene, two mutations of the LPL gene and ApoE. One hundred and forty six subjects completed the intervention diet. While, on average, the intervention was successful (mean weight loss 3.9%), there was no statistically significant difference in the slope coefficients relating lipid change to weight loss for most of the genotypes tested. The slope difference for long versus short 5'VNTR alleles of the apoB gene was 0.445 (-1.307, 2.198) for apolipoprotein B and -0.104 (-1.486, 1.278) for total cholesterol. However, subjects carrying at least one epsilon4 allele were significantly hypo-responsive to weight loss, difference in slope coefficients - 1.087 (-2.09, -0.084) and -1.320 (-2.589, 0.051) for total cholesterol and apoB, respectively. Although, this study is one of the largest of its kind, it has not replicated the findings of other smaller studies. These findings do not provide support for the use of genotype-targeted dietary advice in routine practice. (C) 2000 Elsevier Science Ireland Ltd. hll rights reserved.

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    JO - Atherosclerosis

    T2 - Atherosclerosis

    JF - Atherosclerosis

    SN - 0021-9150

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    Kee F, Young IS, Poirier O, McMaster D, McCrum E, McGeough J et al. Do polymorphisms of apoB, LPL or apoE affect the hypocholesterolemic response to weight loss? Atherosclerosis. 2000 Nov;153(1):119-128.