DNA damage is related to duration of diabetes and BMI

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Under conditions of oxidative stress damage can occur to all cellular biomolecules, including DNA. Such damage has been implicated in the pathogenesis and long-term complications of Type I diabetes. Levels of oxidative DNA damage in eight well controlled individuals with Type I diabetes (mean HbA1c 7.03  0.10) and eight age and gender matched control individuals (mean HbA1c 4.58  0.06) were compared using the modified comet assay. DNA strand breaks, endonuclease III (Endo III) and formamidopyrimidine glycosylase (FPG) sensitive-sites were measured. No significant difference was observed in the mean levels of oxidative DNA damage in the group with diabetes (mean Endo III 9.77  2.6; mean Fpg13.08  2.3) compared to the control group (mean Endo III 12.19  2.2; mean FPG12.48  1.4). However linear regression analysis revealed a statistically significant (p = 0.024) positive correlation between the number of FPG sensitive-sites and duration of Type I diabetes. These results indicate that even with good glycaemic control there was a positive correlation between levels of oxidative DNA damage and duration of Type I diabetes in vivo.
Original languageEnglish
Title of host publicationUnknown Host Publication
PublisherN/A
Number of pages1
Publication statusPublished - 2011
EventDiabetes and Obesity Conference by the ASO and Diabetes UK. - London
Duration: 1 Jan 2011 → …

Conference

ConferenceDiabetes and Obesity Conference by the ASO and Diabetes UK.
Period1/01/11 → …

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