Dissolving microneedles for intradermal vaccination: manufacture, formulation, and stakeholder considerations

Aoife M. Rodgers, Aaron J. Courtenay, Ryan F. Donnelly

Research output: Contribution to journalEditorial

12 Citations (Scopus)

Abstract

Dissolving microneedle (DMN) arrays are minimally invasive
devises that consist of a series of microscopic needles on a base
support. Upon insertion into the skin, the needles dissolve depositing
their payload (Figure 1(A–C)) [1]. DMN have received substantial
interest for intradermal vaccination due to their ease of use
and possibility for self-administration. DMN research is close to
commercialization. However, moving forward, there remain a
number of concerns which warrant investigation. Herein, such
considerations are discussed with a specific focus on the key
challenges for DMN industrialization being highlighted.
Original languageEnglish
Pages (from-to)1039-1043
Number of pages4
JournalExpert Opinion on Drug Delivery
Volume15
Issue number11
Early online date11 Sep 2018
DOIs
Publication statusE-pub ahead of print - 11 Sep 2018

Keywords

  • Dissolving
  • microneedle
  • vaccination
  • immunization
  • scale-up

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