Directed Functional Connectivity in Fronto-Centroparietal Circuit Correlates with Motor Adaptation in Gait Training

Vahab Youssofzadeh, Damiano Zanotto, KongFatt Wong-Lin, Sunil Agrawal, Girijesh Prasad, Sunil Kumar Agrawal

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Lower-extremity robotic exoskeletons are used in gait rehabilitation to achieve functional motor recovery. To date, little is known about how gait training and post-training are characterized in brain signals and their causal connectivity. In this work, we used time-domain partial Granger causality (PGC) analysis to elucidate the directed functional connectivity of electroencephalogram (EEG) signals of healthy adults in robot-assisted gait training (RAGT). Our results confirm the presence of EEG rhythms and corticomuscular relationships during standing and walking using spectral and coherence analyses. The PGC analysis revealed enhanced connectivity close to sensorimotor areas (C3 and CP4) during standing, whereas additional connectivities involve the centroparietal (CPz) and frontal (Fz) areas during walking with respect to standing. In addition, significant fronto-centroparietal causal effects were found during both training and post-training. Strong correlations were also found between kinematic errors and fronto-centroparietal connectivity during training and post-training. This study suggests fronto-centroparietal connectivity as a potential neuromarker for motor learning and adaptation in RAGT.
LanguageEnglish
JournalIEEE Transactions on Neural Systems and Rehabilitation Engineering
Early online date7 Apr 2016
DOIs
Publication statusE-pub ahead of print - 7 Apr 2016

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Gait
Causality
Walking
Electroencephalography
Biomechanical Phenomena
Lower Extremity
Rehabilitation
Learning
Brain

Keywords

  • Active Leg Exoskeleton (ALEX II)
  • connectivity analysis
  • electroencephalography
  • partial Granger causality
  • robot-assisted gait training

Cite this

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title = "Directed Functional Connectivity in Fronto-Centroparietal Circuit Correlates with Motor Adaptation in Gait Training",
abstract = "Lower-extremity robotic exoskeletons are used in gait rehabilitation to achieve functional motor recovery. To date, little is known about how gait training and post-training are characterized in brain signals and their causal connectivity. In this work, we used time-domain partial Granger causality (PGC) analysis to elucidate the directed functional connectivity of electroencephalogram (EEG) signals of healthy adults in robot-assisted gait training (RAGT). Our results confirm the presence of EEG rhythms and corticomuscular relationships during standing and walking using spectral and coherence analyses. The PGC analysis revealed enhanced connectivity close to sensorimotor areas (C3 and CP4) during standing, whereas additional connectivities involve the centroparietal (CPz) and frontal (Fz) areas during walking with respect to standing. In addition, significant fronto-centroparietal causal effects were found during both training and post-training. Strong correlations were also found between kinematic errors and fronto-centroparietal connectivity during training and post-training. This study suggests fronto-centroparietal connectivity as a potential neuromarker for motor learning and adaptation in RAGT.",
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Directed Functional Connectivity in Fronto-Centroparietal Circuit Correlates with Motor Adaptation in Gait Training. / Youssofzadeh, Vahab; Zanotto, Damiano; Wong-Lin, KongFatt; Agrawal, Sunil; Prasad, Girijesh; Agrawal, Sunil Kumar.

In: IEEE Transactions on Neural Systems and Rehabilitation Engineering, 07.04.2016.

Research output: Contribution to journalArticle

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AU - Agrawal, Sunil

AU - Prasad, Girijesh

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