Diffusion of nanoparticles into the capsule and cortex of a crystalline lens

Ronald A. Schachar, Wei Chen, Boon K. Woo, Barbara K. Pierscionek, Xing Zhang, Lun Ma

    Research output: Contribution to journalArticle

    14 Citations (Scopus)

    Abstract

    The purpose of this study is to determine the ability of fluorescent nanoparticles to diffuse into a crystalline lens. Intact porcine lenses from five-month-old pigs, intact human lenses obtained from three donors aged 41, 42 and 45 years, and sections of human lens cortex obtained from four donors aged 11, 19, 32, and 34 years were incubated for 72 h at 7 degrees C in aqueous solutions of green (566 nm) and red (652 nm) fluorescent water soluble cadmium tellurium (CdTe) nanoparticles. As demonstrated by fluorescent and confocal microscopy, the CdTe nanoparticles diffused into the porcine and human lens capsule and into human cortical lens fibres; however, the nanoparticles did not pass through the intact lens capsule. Nanoparticles can be used as a method for studying intracellular structure and biochemical pathways within the lens capsule and cortical lens fibres to further understand cataractogenesis and may serve as a carrier for chemotherapeutic agents for the potential treatment of primary and secondary cataracts.
    LanguageEnglish
    Pages025102
    JournalNanotechnology
    Volume19
    Issue number2
    DOIs
    Publication statusPublished - Jan 2008

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    Capsules
    Lenses
    Nanoparticles
    Crystalline materials
    Tellurium
    Cadmium
    Fibers
    Confocal microscopy
    Water

    Cite this

    Schachar, R. A., Chen, W., Woo, B. K., Pierscionek, B. K., Zhang, X., & Ma, L. (2008). Diffusion of nanoparticles into the capsule and cortex of a crystalline lens. Nanotechnology, 19(2), 025102. https://doi.org/10.1088/0957-4484/19/02/025102
    Schachar, Ronald A. ; Chen, Wei ; Woo, Boon K. ; Pierscionek, Barbara K. ; Zhang, Xing ; Ma, Lun. / Diffusion of nanoparticles into the capsule and cortex of a crystalline lens. In: Nanotechnology. 2008 ; Vol. 19, No. 2. pp. 025102.
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    abstract = "The purpose of this study is to determine the ability of fluorescent nanoparticles to diffuse into a crystalline lens. Intact porcine lenses from five-month-old pigs, intact human lenses obtained from three donors aged 41, 42 and 45 years, and sections of human lens cortex obtained from four donors aged 11, 19, 32, and 34 years were incubated for 72 h at 7 degrees C in aqueous solutions of green (566 nm) and red (652 nm) fluorescent water soluble cadmium tellurium (CdTe) nanoparticles. As demonstrated by fluorescent and confocal microscopy, the CdTe nanoparticles diffused into the porcine and human lens capsule and into human cortical lens fibres; however, the nanoparticles did not pass through the intact lens capsule. Nanoparticles can be used as a method for studying intracellular structure and biochemical pathways within the lens capsule and cortical lens fibres to further understand cataractogenesis and may serve as a carrier for chemotherapeutic agents for the potential treatment of primary and secondary cataracts.",
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    Schachar, RA, Chen, W, Woo, BK, Pierscionek, BK, Zhang, X & Ma, L 2008, 'Diffusion of nanoparticles into the capsule and cortex of a crystalline lens', Nanotechnology, vol. 19, no. 2, pp. 025102. https://doi.org/10.1088/0957-4484/19/02/025102

    Diffusion of nanoparticles into the capsule and cortex of a crystalline lens. / Schachar, Ronald A.; Chen, Wei; Woo, Boon K.; Pierscionek, Barbara K.; Zhang, Xing; Ma, Lun.

    In: Nanotechnology, Vol. 19, No. 2, 01.2008, p. 025102.

    Research output: Contribution to journalArticle

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