Differential TERT promoter methylation and response to 5-aza-2'-deoxycytidine in acute myeloid leukemia cell lines: TERT expression, telomerase activity, telomere length, and cell death

K.A. Pettigrew, R.N. Armstrong, H.A.A. Colyer, S.-D. Zhang, I.M. Rea, R.E. Jones, D.M. Baird, K.I. Mills

    Research output: Contribution to journalArticle

    Original languageEnglish
    Pages (from-to)768-780
    JournalGenes, Chromosomes and Cancer
    Volume51
    Issue number8
    DOIs
    Publication statusPublished - 2012

    Keywords

    • EMTREE drug terms: 5 aza 2' deoxycytidine
    • messenger RNA
    • telomerase reverse transcriptase
    • EMTREE medical terms: acute granulocytic leukemia
    • aged
    • article
    • cancer patient
    • cancer resistance
    • cell death
    • cell strain HL 60
    • cell strain U937
    • cell viability
    • clinical article
    • controlled study
    • CpG island
    • demethylation
    • DNA methylation
    • DNA sequence
    • enzyme activity
    • female
    • gene expression
    • genetic parameters
    • human
    • human cell
    • leukemia cell
    • lymphoma cell
    • male
    • priority journal
    • promoter region
    • protein expression
    • pyrosequencing
    • telomere length
    • MeSH: Aged
    • 80 and over
    • Antimetabolites
    • Antineoplastic
    • Azacitidine
    • Cell Death
    • Cell Line
    • Tumor
    • CpG Islands
    • DNA Methylation
    • Female
    • Gene Expression Regulation
    • Neoplastic
    • HL-60 Cells
    • Humans
    • Leukemia
    • Myeloid
    • Acute
    • Male
    • Promoter Regions
    • Genetic
    • Telomerase
    • Telomere
    • U937 Cells

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