DIFFERENTIAL-PULSE POLAROGRAPHIC STUDY OF THE DEGRADATION OF H+/K+ ATPASE INHIBITORS SK-AND-F-95601 AND OMEPRAZOLE IN ACIDIC MEDIA AND THE SUBSEQUENT REACTIONS WITH THIOLS

Stephen McClean; E O'KANE; VN RAMACHANDRAN; Franklin Smyth

DIFFERENTIAL-PULSE POLAROGRAPHIC STUDY OF THE DEGRADATION OF H+/K+ ATPASE INHIBITORS SK-AND-F-95601 AND OMEPRAZOLE IN ACIDIC MEDIA AND THE SUBSEQUENT REACTIONS WITH THIOLS

Stephen McClean, E O'KANE, VN RAMACHANDRAN, Franklin Smyth

Faculty Of Life & Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Differential pulse polarography (DPP) has been used to monitor the degradation of benzimidazole sulphoxide antiulcer drugs SK&F 95601 and omeprazole in 10(-2) mol dm(-3) HCl to two main products, i.e., the sulphenamide and the benzimidazole sulphide. It is also used to follow the reactions of 2-mercaptoethanol with the respective products of these degradations, as simulations of their believed reactions in vivo. These reactions are also followed by UV spectrophotometry, spectrofluorimetry and liquid chromatography. DPP can also be used to selectively determine nanomolar concentrations of these antiulcer drugs and their degradation products, of value in formulation and body fluid analysis.

Original language	English
Pages (from-to)	81-89
Journal	Analytica Chimica Acta
Volume	292
Issue number	1-2
Publication status	Published (in print/issue) - Jun 1994

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title = "DIFFERENTIAL-PULSE POLAROGRAPHIC STUDY OF THE DEGRADATION OF H+/K+ ATPASE INHIBITORS SK-AND-F-95601 AND OMEPRAZOLE IN ACIDIC MEDIA AND THE SUBSEQUENT REACTIONS WITH THIOLS",

abstract = "Differential pulse polarography (DPP) has been used to monitor the degradation of benzimidazole sulphoxide antiulcer drugs SK&F 95601 and omeprazole in 10(-2) mol dm(-3) HCl to two main products, i.e., the sulphenamide and the benzimidazole sulphide. It is also used to follow the reactions of 2-mercaptoethanol with the respective products of these degradations, as simulations of their believed reactions in vivo. These reactions are also followed by UV spectrophotometry, spectrofluorimetry and liquid chromatography. DPP can also be used to selectively determine nanomolar concentrations of these antiulcer drugs and their degradation products, of value in formulation and body fluid analysis.",

author = "Stephen McClean and E O'KANE and VN RAMACHANDRAN and Franklin Smyth",

year = "1994",

month = jun,

language = "English",

volume = "292",

pages = "81--89",

journal = "Analytica Chimica Acta",

issn = "1873-4324",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - DIFFERENTIAL-PULSE POLAROGRAPHIC STUDY OF THE DEGRADATION OF H+/K+ ATPASE INHIBITORS SK-AND-F-95601 AND OMEPRAZOLE IN ACIDIC MEDIA AND THE SUBSEQUENT REACTIONS WITH THIOLS

AU - McClean, Stephen

AU - O'KANE, E

AU - RAMACHANDRAN, VN

AU - Smyth, Franklin

PY - 1994/6

Y1 - 1994/6

N2 - Differential pulse polarography (DPP) has been used to monitor the degradation of benzimidazole sulphoxide antiulcer drugs SK&F 95601 and omeprazole in 10(-2) mol dm(-3) HCl to two main products, i.e., the sulphenamide and the benzimidazole sulphide. It is also used to follow the reactions of 2-mercaptoethanol with the respective products of these degradations, as simulations of their believed reactions in vivo. These reactions are also followed by UV spectrophotometry, spectrofluorimetry and liquid chromatography. DPP can also be used to selectively determine nanomolar concentrations of these antiulcer drugs and their degradation products, of value in formulation and body fluid analysis.

AB - Differential pulse polarography (DPP) has been used to monitor the degradation of benzimidazole sulphoxide antiulcer drugs SK&F 95601 and omeprazole in 10(-2) mol dm(-3) HCl to two main products, i.e., the sulphenamide and the benzimidazole sulphide. It is also used to follow the reactions of 2-mercaptoethanol with the respective products of these degradations, as simulations of their believed reactions in vivo. These reactions are also followed by UV spectrophotometry, spectrofluorimetry and liquid chromatography. DPP can also be used to selectively determine nanomolar concentrations of these antiulcer drugs and their degradation products, of value in formulation and body fluid analysis.

M3 - Article

SN - 1873-4324

VL - 292

SP - 81

EP - 89

JO - Analytica Chimica Acta

JF - Analytica Chimica Acta

IS - 1-2

ER -

DIFFERENTIAL-PULSE POLAROGRAPHIC STUDY OF THE DEGRADATION OF H+/K+ ATPASE INHIBITORS SK-AND-F-95601 AND OMEPRAZOLE IN ACIDIC MEDIA AND THE SUBSEQUENT REACTIONS WITH THIOLS

Abstract

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