Differential effects of isoflavones and lignans on invasiveness of MDA-MB-231 breast cancer cells in vitro

Pamela Magee, H McGlynn, IR Rowland

Research output: Contribution to journalArticle

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Abstract

Metastasis is a major cause of morbidity and mortality in breast cancer with tumour cell invasion playing a crucial role in the metastatic process. The effects of a panel of phytoestrogens, including isoflavones and lignans on the invasion of a breast cancer cell-line (MDA-MB-231) through Matrigel were assessed. Genistein, glycitein, daidzein, equol, O-Desmethylangolensin (O-Dma) and coumestrol exerted a potent inhibitory effect on cell invasion (e.g. inhibition of 41.7 +/- 15% (P = 0.007); coumestrol (10 muM)). In contrast the lignans exerted minimal effects on invasion. Inhibition of invasion induced by the phytoestrogens occurred without affecting cell viability, highlighting the possible chemoprotective effects of these compounds. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
LanguageEnglish
Pages35-41
JournalCancer Letters
Volume208
Issue number1
DOIs
Publication statusPublished - May 2004

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Coumestrol
Phytoestrogens
Lignans
Isoflavones
Equol
Breast Neoplasms
Genistein
Cell Survival
Neoplasm Metastasis
Morbidity
Cell Line
Mortality
Neoplasms
In Vitro Techniques

Cite this

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abstract = "Metastasis is a major cause of morbidity and mortality in breast cancer with tumour cell invasion playing a crucial role in the metastatic process. The effects of a panel of phytoestrogens, including isoflavones and lignans on the invasion of a breast cancer cell-line (MDA-MB-231) through Matrigel were assessed. Genistein, glycitein, daidzein, equol, O-Desmethylangolensin (O-Dma) and coumestrol exerted a potent inhibitory effect on cell invasion (e.g. inhibition of 41.7 +/- 15{\%} (P = 0.007); coumestrol (10 muM)). In contrast the lignans exerted minimal effects on invasion. Inhibition of invasion induced by the phytoestrogens occurred without affecting cell viability, highlighting the possible chemoprotective effects of these compounds. (C) 2003 Elsevier Ireland Ltd. All rights reserved.",
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Differential effects of isoflavones and lignans on invasiveness of MDA-MB-231 breast cancer cells in vitro. / Magee, Pamela; McGlynn, H; Rowland, IR.

In: Cancer Letters, Vol. 208, No. 1, 05.2004, p. 35-41.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Differential effects of isoflavones and lignans on invasiveness of MDA-MB-231 breast cancer cells in vitro

AU - Magee, Pamela

AU - McGlynn, H

AU - Rowland, IR

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AB - Metastasis is a major cause of morbidity and mortality in breast cancer with tumour cell invasion playing a crucial role in the metastatic process. The effects of a panel of phytoestrogens, including isoflavones and lignans on the invasion of a breast cancer cell-line (MDA-MB-231) through Matrigel were assessed. Genistein, glycitein, daidzein, equol, O-Desmethylangolensin (O-Dma) and coumestrol exerted a potent inhibitory effect on cell invasion (e.g. inhibition of 41.7 +/- 15% (P = 0.007); coumestrol (10 muM)). In contrast the lignans exerted minimal effects on invasion. Inhibition of invasion induced by the phytoestrogens occurred without affecting cell viability, highlighting the possible chemoprotective effects of these compounds. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

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