Dietary Interventions in the Management of Fibromyalgia: A Systematic Review and Best-Evidence Synthesis

Research output: Contribution to journalReview articlepeer-review

28 Citations (Scopus)
66 Downloads (Pure)


Fibromyalgia syndrome (FMS) is characterised by chronic widespread pain alongside fatigue, poor sleep quality and numerous comorbidities. It is estimated to have a worldwide prevalence of 1.78%, with a predominance in females. Treatment interventions for fibromyalgia have limited success, leading to many patients seeking alternative forms of treatment, including modifications to their diet and lifestyle. The effectiveness of dietary changes in fibromyalgia has not been widely researched or evaluated. This systematic review identified twenty-two studies, including 18 randomised control trials (RCTs) and four cohort studies which were eligible for inclusion. In total these studies investigated 17 different nutritional interventions. Significant improvements in reported pain were observed for those following a vegan diet, as well as with the low fermentable oligo di-mono-saccharides and polyols (FODMAP) diets. Supplementation with Chlorella green algae, coenzyme Q10, acetyl-l-carnitine or a combination of vitamin C and E significantly improved measures of pain. Interpretation of these studies was limited due to the frequent poor quality of the study design, the wide heterogeneity between studies, the small sample size and a high degree of bias. Therefore, there is insufficient evidence to recommend any one particular nutritional intervention for the management of fibromyalgia and further research is needed.
Original languageEnglish
Article number2664
Pages (from-to)1-18
Number of pages18
Issue number9
Publication statusPublished (in print/issue) - 31 Aug 2020

Bibliographical note

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Copyright 2020 Elsevier B.V., All rights reserved.


  • Diet
  • Fibromyalgia
  • Musculoskeletal
  • Nutrition
  • Pain
  • Rheumatology
  • Sleep


Dive into the research topics of 'Dietary Interventions in the Management of Fibromyalgia: A Systematic Review and Best-Evidence Synthesis'. Together they form a unique fingerprint.

Cite this