Dietary Fish-Oil Supplementation Alters Leukocyte Funciton and Cytokine Production in Healthy Women

JMW Wallace, E Turley, WS Gilmore, JJ Strain

Research output: Contribution to journalArticle

Abstract

The effect of low-dose fish oil supplementation on cytokines and white cell function in women was investigated. Thirty-three healthy, nonsmoking women entered the double-blind study. For 4 weeks, 2.4 g of either fish oil (n=16) or fish oil with vitamin E (n=17) was added daily to the subjects' otherwise unchanged diets. Venous blood samples were taken at the onset of the trial, after the supplementation period, and again after a 9-week washout period. Plasma levels of platelet-derived growth factor and myeloperoxidase were measured using immunoassays. The intracellular peroxidase content of white blood cells was measured using a staining technique. Platelet-derived growth factor levels were significantly lowered after supplementation (P less than or equal to.05). Intracellular peroxidase was increased (P less than or equal to.01), and extracellular myeloperoxidase levels were lowered (P less than or equal to.05). Taken together, these results suggest that the anti-inflammatory effect of fish oil may be due at least partly to alterations in white cell function and growth factor levels.
LanguageEnglish
Pages185-189
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume15
Issue number2
Publication statusPublished - Feb 1995

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Unsaturated Dietary Fats
Fish Oils
Peroxidase
Leukocytes
Cytokines
Platelet-Derived Growth Factor
Vitamin E
Immunoassay
Double-Blind Method
Intercellular Signaling Peptides and Proteins
Anti-Inflammatory Agents
Staining and Labeling
Diet

Cite this

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title = "Dietary Fish-Oil Supplementation Alters Leukocyte Funciton and Cytokine Production in Healthy Women",
abstract = "The effect of low-dose fish oil supplementation on cytokines and white cell function in women was investigated. Thirty-three healthy, nonsmoking women entered the double-blind study. For 4 weeks, 2.4 g of either fish oil (n=16) or fish oil with vitamin E (n=17) was added daily to the subjects' otherwise unchanged diets. Venous blood samples were taken at the onset of the trial, after the supplementation period, and again after a 9-week washout period. Plasma levels of platelet-derived growth factor and myeloperoxidase were measured using immunoassays. The intracellular peroxidase content of white blood cells was measured using a staining technique. Platelet-derived growth factor levels were significantly lowered after supplementation (P less than or equal to.05). Intracellular peroxidase was increased (P less than or equal to.01), and extracellular myeloperoxidase levels were lowered (P less than or equal to.05). Taken together, these results suggest that the anti-inflammatory effect of fish oil may be due at least partly to alterations in white cell function and growth factor levels.",
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Dietary Fish-Oil Supplementation Alters Leukocyte Funciton and Cytokine Production in Healthy Women. / Wallace, JMW; Turley, E; Gilmore, WS; Strain, JJ.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 15, No. 2, 02.1995, p. 185-189.

Research output: Contribution to journalArticle

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AU - Wallace, JMW

AU - Turley, E

AU - Gilmore, WS

AU - Strain, JJ

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AB - The effect of low-dose fish oil supplementation on cytokines and white cell function in women was investigated. Thirty-three healthy, nonsmoking women entered the double-blind study. For 4 weeks, 2.4 g of either fish oil (n=16) or fish oil with vitamin E (n=17) was added daily to the subjects' otherwise unchanged diets. Venous blood samples were taken at the onset of the trial, after the supplementation period, and again after a 9-week washout period. Plasma levels of platelet-derived growth factor and myeloperoxidase were measured using immunoassays. The intracellular peroxidase content of white blood cells was measured using a staining technique. Platelet-derived growth factor levels were significantly lowered after supplementation (P less than or equal to.05). Intracellular peroxidase was increased (P less than or equal to.01), and extracellular myeloperoxidase levels were lowered (P less than or equal to.05). Taken together, these results suggest that the anti-inflammatory effect of fish oil may be due at least partly to alterations in white cell function and growth factor levels.

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