Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage

Hamid A. Bakshi, Mazhar S Al Zoubi, Hakkim L. Faruck, Alaa A A Aljabali, Firas A. Rabi, Amin A. Hafiz, Khalid M Al-batanyeh, Bahaa Al-trad, Prawej Ansari, Mohamed M. Nasef, Nitin B. Charbe, Saurabh Satija, Meenu Mehta, Vijay Mishra, Gaurav Gupta, Salem Abobaker, Poonam Negi, Ibrahim M. Azzouz, Ashref Ali K Dardouri, Harish DurejaParteek Prasher, Dinesh K. Chellappan, Kamal Dua, Mateus Webba Da Silva, Mohamed El Tanani, Paul A. Mccarron, Murtaza M. Tambuwala

Research output: Contribution to journalArticle

3 Citations (Scopus)
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Abstract

Pancreatic cancer is one of the fatal causes of global cancer-related deaths. Although
surgery and chemotherapy are standard treatment options, post-treatment outcomes often end in a poor prognosis. In the present study, we investigated anti-pancreatic cancer and amelioration of radiation-induced oxidative damage by crocin. Crocin is a carotenoid isolated from the dietary herb saffron, a prospect for novel leads as an anti-cancer agent. Crocin significantly reduced cell viability of BXPC3 and Capan-2 by triggering caspase signaling via the downregulation of Bcl-2. It modulated the expression of cell cycle signaling proteins P53, P21, P27, CDK2, c-MYC, Cyt-c and P38. Concomitantly, crocin treatment-induced apoptosis by inducing the release of cytochrome c from mitochondria to cytosol. Microarray analysis of the expression signature of genes induced by crocin showed a substantial number of genes involved in cell signaling pathways and checkpoints (723) are significantly affected by crocin. In mice bearing pancreatic tumors, crocin significantly reduced tumor burden without a change in body weight. Additionally, it showed significant protection against radiation-induced hepatic oxidative damage, reduced the levels of hepatic toxicity and preserved liver morphology. These findings indicate that crocin has a potential role in the treatment, prevention and management of pancreatic cancer.
Original languageEnglish
Article number1901
Pages (from-to)1-19
Number of pages19
JournalNutrients
Volume12
Issue number6
DOIs
Publication statusPublished - 26 Jun 2020

Keywords

  • Apoptosis
  • Cell cycle
  • Crocin
  • Hepatic injury
  • Pancreatic cancer
  • Radiation

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