Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage

Hamid A. Bakshi; Mazhar S Al Zoubi; Hakkim L. Faruck; Alaa A A Aljabali; Firas A. Rabi; Amin A. Hafiz; Khalid M Al-batanyeh; Bahaa Al-trad; Prawej Ansari; Mohamed M. Nasef; Nitin B. Charbe; Saurabh Satija; Meenu Mehta; Vijay Mishra; Gaurav Gupta; Salem Abobaker; Poonam Negi; Ibrahim M. Azzouz; Ashref Ali K Dardouri; Harish Dureja; Parteek Prasher; Dinesh K. Chellappan; Kamal Dua; Mateus Webba Da Silva; Mohamed El Tanani; Paul A. Mccarron; Murtaza M. Tambuwala

doi:10.3390/nu12061901

Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage

Hamid A. Bakshi, Mazhar S Al Zoubi, Hakkim L. Faruck, Alaa A A Aljabali, Firas A. Rabi, Amin A. Hafiz, Khalid M Al-batanyeh, Bahaa Al-trad, Prawej Ansari, Mohamed M. Nasef, Nitin B. Charbe, Saurabh Satija, Meenu Mehta, Vijay Mishra, Gaurav Gupta, Salem Abobaker, Poonam Negi, Ibrahim M. Azzouz, Ashref Ali K Dardouri, Harish DurejaParteek Prasher, Dinesh K. Chellappan, Kamal Dua, Mateus Webba Da Silva, Mohamed El Tanani, Paul A. Mccarron, Murtaza M. Tambuwala

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Abstract

Pancreatic cancer is one of the fatal causes of global cancer-related deaths. Although
surgery and chemotherapy are standard treatment options, post-treatment outcomes often end in a poor prognosis. In the present study, we investigated anti-pancreatic cancer and amelioration of radiation-induced oxidative damage by crocin. Crocin is a carotenoid isolated from the dietary herb saffron, a prospect for novel leads as an anti-cancer agent. Crocin significantly reduced cell viability of BXPC3 and Capan-2 by triggering caspase signaling via the downregulation of Bcl-2. It modulated the expression of cell cycle signaling proteins P53, P21, P27, CDK2, c-MYC, Cyt-c and P38. Concomitantly, crocin treatment-induced apoptosis by inducing the release of cytochrome c from mitochondria to cytosol. Microarray analysis of the expression signature of genes induced by crocin showed a substantial number of genes involved in cell signaling pathways and checkpoints (723) are significantly affected by crocin. In mice bearing pancreatic tumors, crocin significantly reduced tumor burden without a change in body weight. Additionally, it showed significant protection against radiation-induced hepatic oxidative damage, reduced the levels of hepatic toxicity and preserved liver morphology. These findings indicate that crocin has a potential role in the treatment, prevention and management of pancreatic cancer.

Original language	English
Article number	1901
Pages (from-to)	1-19
Number of pages	19
Journal	Nutrients
Volume	12
Issue number	6
DOIs	https://doi.org/10.3390/nu12061901
Publication status	Published (in print/issue) - 26 Jun 2020

Keywords

Apoptosis
Cell cycle
Crocin
Hepatic injury
Pancreatic cancer
Radiation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Bakshi, H. A., Zoubi, M. S. A., Faruck, H. L., Aljabali, A. A. A., Rabi, F. A., Hafiz, A. A., Al-batanyeh, K. M., Al-trad, B., Ansari, P., Nasef, M. M., Charbe, N. B., Satija, S., Mehta, M., Mishra, V., Gupta, G., Abobaker, S., Negi, P., Azzouz, I. M., Dardouri, A. A. K., ... M. Tambuwala, M. (2020). Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage. Nutrients, 12(6), 1-19. Article 1901. https://doi.org/10.3390/nu12061901

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title = "Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage",

abstract = "Pancreatic cancer is one of the fatal causes of global cancer-related deaths. Althoughsurgery and chemotherapy are standard treatment options, post-treatment outcomes often end in a poor prognosis. In the present study, we investigated anti-pancreatic cancer and amelioration of radiation-induced oxidative damage by crocin. Crocin is a carotenoid isolated from the dietary herb saffron, a prospect for novel leads as an anti-cancer agent. Crocin significantly reduced cell viability of BXPC3 and Capan-2 by triggering caspase signaling via the downregulation of Bcl-2. It modulated the expression of cell cycle signaling proteins P53, P21, P27, CDK2, c-MYC, Cyt-c and P38. Concomitantly, crocin treatment-induced apoptosis by inducing the release of cytochrome c from mitochondria to cytosol. Microarray analysis of the expression signature of genes induced by crocin showed a substantial number of genes involved in cell signaling pathways and checkpoints (723) are significantly affected by crocin. In mice bearing pancreatic tumors, crocin significantly reduced tumor burden without a change in body weight. Additionally, it showed significant protection against radiation-induced hepatic oxidative damage, reduced the levels of hepatic toxicity and preserved liver morphology. These findings indicate that crocin has a potential role in the treatment, prevention and management of pancreatic cancer.",

keywords = "Apoptosis, Cell cycle, Crocin, Hepatic injury, Pancreatic cancer, Radiation",

author = "Bakshi, {Hamid A.} and Zoubi, {Mazhar S Al} and Faruck, {Hakkim L.} and Aljabali, {Alaa A A} and Rabi, {Firas A.} and Hafiz, {Amin A.} and Al-batanyeh, {Khalid M} and Bahaa Al-trad and Prawej Ansari and Nasef, {Mohamed M.} and Charbe, {Nitin B.} and Saurabh Satija and Meenu Mehta and Vijay Mishra and Gaurav Gupta and Salem Abobaker and Poonam Negi and Azzouz, {Ibrahim M.} and Dardouri, {Ashref Ali K} and Harish Dureja and Parteek Prasher and Chellappan, {Dinesh K.} and Kamal Dua and Silva, {Mateus Webba Da} and Tanani, {Mohamed El} and Mccarron, {Paul A.} and {M. Tambuwala}, Murtaza",

year = "2020",

month = jun,

day = "26",

doi = "10.3390/nu12061901",

language = "English",

volume = "12",

pages = "1--19",

journal = "Nutrients",

issn = "2072-6643",

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number = "6",

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Bakshi, HA, Zoubi, MSA, Faruck, HL, Aljabali, AAA, Rabi, FA, Hafiz, AA, Al-batanyeh, KM, Al-trad, B, Ansari, P, Nasef, MM, Charbe, NB, Satija, S, Mehta, M, Mishra, V, Gupta, G, Abobaker, S, Negi, P, Azzouz, IM, Dardouri, AAK, Dureja, H, Prasher, P, Chellappan, DK, Dua, K, Silva, MWD, Tanani, ME, Mccarron, PA & M. Tambuwala, M 2020, 'Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage', Nutrients, vol. 12, no. 6, 1901, pp. 1-19. https://doi.org/10.3390/nu12061901

TY - JOUR

T1 - Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage

AU - Bakshi, Hamid A.

AU - Zoubi, Mazhar S Al

AU - Faruck, Hakkim L.

AU - Aljabali, Alaa A A

AU - Rabi, Firas A.

AU - Hafiz, Amin A.

AU - Al-batanyeh, Khalid M

AU - Al-trad, Bahaa

AU - Ansari, Prawej

AU - Nasef, Mohamed M.

AU - Charbe, Nitin B.

AU - Satija, Saurabh

AU - Mehta, Meenu

AU - Mishra, Vijay

AU - Gupta, Gaurav

AU - Abobaker, Salem

AU - Negi, Poonam

AU - Azzouz, Ibrahim M.

AU - Dardouri, Ashref Ali K

AU - Dureja, Harish

AU - Prasher, Parteek

AU - Chellappan, Dinesh K.

AU - Dua, Kamal

AU - Silva, Mateus Webba Da

AU - Tanani, Mohamed El

AU - Mccarron, Paul A.

AU - M. Tambuwala, Murtaza

PY - 2020/6/26

Y1 - 2020/6/26

N2 - Pancreatic cancer is one of the fatal causes of global cancer-related deaths. Althoughsurgery and chemotherapy are standard treatment options, post-treatment outcomes often end in a poor prognosis. In the present study, we investigated anti-pancreatic cancer and amelioration of radiation-induced oxidative damage by crocin. Crocin is a carotenoid isolated from the dietary herb saffron, a prospect for novel leads as an anti-cancer agent. Crocin significantly reduced cell viability of BXPC3 and Capan-2 by triggering caspase signaling via the downregulation of Bcl-2. It modulated the expression of cell cycle signaling proteins P53, P21, P27, CDK2, c-MYC, Cyt-c and P38. Concomitantly, crocin treatment-induced apoptosis by inducing the release of cytochrome c from mitochondria to cytosol. Microarray analysis of the expression signature of genes induced by crocin showed a substantial number of genes involved in cell signaling pathways and checkpoints (723) are significantly affected by crocin. In mice bearing pancreatic tumors, crocin significantly reduced tumor burden without a change in body weight. Additionally, it showed significant protection against radiation-induced hepatic oxidative damage, reduced the levels of hepatic toxicity and preserved liver morphology. These findings indicate that crocin has a potential role in the treatment, prevention and management of pancreatic cancer.

AB - Pancreatic cancer is one of the fatal causes of global cancer-related deaths. Althoughsurgery and chemotherapy are standard treatment options, post-treatment outcomes often end in a poor prognosis. In the present study, we investigated anti-pancreatic cancer and amelioration of radiation-induced oxidative damage by crocin. Crocin is a carotenoid isolated from the dietary herb saffron, a prospect for novel leads as an anti-cancer agent. Crocin significantly reduced cell viability of BXPC3 and Capan-2 by triggering caspase signaling via the downregulation of Bcl-2. It modulated the expression of cell cycle signaling proteins P53, P21, P27, CDK2, c-MYC, Cyt-c and P38. Concomitantly, crocin treatment-induced apoptosis by inducing the release of cytochrome c from mitochondria to cytosol. Microarray analysis of the expression signature of genes induced by crocin showed a substantial number of genes involved in cell signaling pathways and checkpoints (723) are significantly affected by crocin. In mice bearing pancreatic tumors, crocin significantly reduced tumor burden without a change in body weight. Additionally, it showed significant protection against radiation-induced hepatic oxidative damage, reduced the levels of hepatic toxicity and preserved liver morphology. These findings indicate that crocin has a potential role in the treatment, prevention and management of pancreatic cancer.

KW - Apoptosis

KW - Cell cycle

KW - Crocin

KW - Hepatic injury

KW - Pancreatic cancer

KW - Radiation

UR - http://www.scopus.com/inward/record.url?scp=85087398483&partnerID=8YFLogxK

U2 - 10.3390/nu12061901

DO - 10.3390/nu12061901

M3 - Article

C2 - 32604971

SN - 2072-6643

VL - 12

SP - 1

EP - 19

JO - Nutrients

JF - Nutrients

IS - 6

M1 - 1901

ER -

Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage

Abstract

Keywords

UN SDGs

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