Diet and cancer: assessing the risk

Chris Gill, IR Rowland

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Globally, colorectal cancer (CRC) is a leading cause of mortality from malignant disease. Case-control and cohort studies provide strong support for a role of diet in the aetiology of CRC. However to establish causal relationships and to identify more precisely the dietary components involved, intervention studies in human subjects are required. Cancer is an impractical endpoint in terms of numbers, cost, study duration and ethical considerations. Consequently, intermediate biomarkers of the disease are required. This review aims to provide an overview of the intermediate endpoints available for the study of CRC, particularly non-invasive faecal biomarkers. Examples of their use in dietary intervention studies are given.
Original languageEnglish
Pages (from-to)S73-S87
JournalBRITISH JOURNAL OF NUTRITION
Volume88
Issue numberSuppl.
DOIs
Publication statusPublished - Sep 2002

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