Development of Water-Soluble Electrospun Fibers for the Oral Delivery of Cannabinoids

Eleftherios G. Andriotis, Konstantina Chachlioutaki, Paraskevi Kyriaki Monou, Nikolaos Bouropoulos, Dimitrios Tzetzis, Panagiotis Barmpalexis, Ming Wei Chang, Zeeshan Ahmad, Dimitrios G. Fatouros

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Cannabidiol (CBD) and cannabigerol (CBG) are two active pharmaceutical ingredients, derived from cannabis plant. In the present study, CBD and CBG were formulated with polyvinyl(pyrrolidone) (PVP) and Eudragit L-100, using electrohydrodynamic atomization (electrospinning). The produced fibers were smooth and uniform in shape, with average fiber diameters in the range of 700–900 nm for PVP fibers and 1–5 μm for Eudragit L-100 fibers. The encapsulation efficiency for both CB and CBG was high (over 90%) for all formulations tested. Both in vitro release and disintegration tests of the formulations in simulated gastric fluids (SGF) and simulated intestinal fluids (SIF) indicated the rapid disintegration and dissolution of the fibers and the subsequent rapid release of the drugs. The study concluded that the electrospinning process is a fast and efficient method to produce drug-loaded fibers suitable for the per os administration of cannabinoids.

Original languageEnglish
Article number23
JournalAAPS PharmSciTech
Volume22
Issue number1
Early online date5 Jan 2021
DOIs
Publication statusE-pub ahead of print - 5 Jan 2021

Keywords

  • cannabinoids
  • cannabidiol
  • cannabigerol
  • electrospinning
  • solid dispersion
  • nanofibers
  • Administration, Oral
  • Cannabidiol/administration & dosage
  • Cannabinoids/administration & dosage
  • Polymethacrylic Acids/chemistry
  • Nanofibers/chemistry
  • Povidone/chemistry
  • Drug Compounding
  • Drug Liberation

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