Abstract
Fibrous technologies (such as membranes, films, patches and filters) and their enabling engineering platforms have gained considerable interest over the last decade. In this study, novel fibrous constructs from a unique engineering platform were developed based on hybrid electrohydrodynamic (EHD) technology; incorporating functional and bioactive materials within random and aligned fibrous formulation geometries. Complex constructs were engineered using 3D printing (polycaprolactone, PCL, for sustained delivery) and electrospinning (polyvinylpyrrolidone, PVP, for rapid release) in an intercalating material layer-by-layer format using a side-by-side technological approach. Here, structure generation proceeded with deposition of ordered PCL fibers enabling well-defined void size and overall dimension, after which randomly spun PVP fibers formed a construct overcoat (as a membrane). Differences between polymer dissolution rate, hydrophilicity, mechanical properties and functional material hosting (and linked external auxiliary magnetic field trigger) provided opportunities to modulate antibiotic drug (tetracycline hydrochloride, TE-HCl) release. In vitro cell studies using human umbilical vein blood vessel cell line demonstrated device biocompatibility and Escherichia Coli (E. coli) was selected to demonstrate anti-bacterial function. Overall, a new hybrid engineering platform to prepare customizable and exciting multi-faceted drug release constructs is elucidated.
| Language | English |
|---|---|
| Pages | 379-389 |
| Number of pages | 11 |
| Journal | Chemical Engineering Journal |
| Volume | 343 |
| Early online date | 6 Mar 2018 |
| DOIs | |
| Publication status | Published - 1 Jul 2018 |
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Keywords
- EHD continuous jetting
- Electrospinning
- Hybrid system
- Rapid drug release
- Sustained drug release
Cite this
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Development of random and ordered composite fiber hybrid technologies for controlled release functions. / Wang, Baolin; Ahmad, Zeeshan; Huang, Jie; Li, Jing song; Chang, Ming Wei.
In: Chemical Engineering Journal, Vol. 343, 01.07.2018, p. 379-389.Research output: Contribution to journal › Article
TY - JOUR
T1 - Development of random and ordered composite fiber hybrid technologies for controlled release functions
AU - Wang, Baolin
AU - Ahmad, Zeeshan
AU - Huang, Jie
AU - Li, Jing song
AU - Chang, Ming Wei
N1 - Ming-Wei was employed in China at the time of acceptance and publication
PY - 2018/7/1
Y1 - 2018/7/1
N2 - Fibrous technologies (such as membranes, films, patches and filters) and their enabling engineering platforms have gained considerable interest over the last decade. In this study, novel fibrous constructs from a unique engineering platform were developed based on hybrid electrohydrodynamic (EHD) technology; incorporating functional and bioactive materials within random and aligned fibrous formulation geometries. Complex constructs were engineered using 3D printing (polycaprolactone, PCL, for sustained delivery) and electrospinning (polyvinylpyrrolidone, PVP, for rapid release) in an intercalating material layer-by-layer format using a side-by-side technological approach. Here, structure generation proceeded with deposition of ordered PCL fibers enabling well-defined void size and overall dimension, after which randomly spun PVP fibers formed a construct overcoat (as a membrane). Differences between polymer dissolution rate, hydrophilicity, mechanical properties and functional material hosting (and linked external auxiliary magnetic field trigger) provided opportunities to modulate antibiotic drug (tetracycline hydrochloride, TE-HCl) release. In vitro cell studies using human umbilical vein blood vessel cell line demonstrated device biocompatibility and Escherichia Coli (E. coli) was selected to demonstrate anti-bacterial function. Overall, a new hybrid engineering platform to prepare customizable and exciting multi-faceted drug release constructs is elucidated.
AB - Fibrous technologies (such as membranes, films, patches and filters) and their enabling engineering platforms have gained considerable interest over the last decade. In this study, novel fibrous constructs from a unique engineering platform were developed based on hybrid electrohydrodynamic (EHD) technology; incorporating functional and bioactive materials within random and aligned fibrous formulation geometries. Complex constructs were engineered using 3D printing (polycaprolactone, PCL, for sustained delivery) and electrospinning (polyvinylpyrrolidone, PVP, for rapid release) in an intercalating material layer-by-layer format using a side-by-side technological approach. Here, structure generation proceeded with deposition of ordered PCL fibers enabling well-defined void size and overall dimension, after which randomly spun PVP fibers formed a construct overcoat (as a membrane). Differences between polymer dissolution rate, hydrophilicity, mechanical properties and functional material hosting (and linked external auxiliary magnetic field trigger) provided opportunities to modulate antibiotic drug (tetracycline hydrochloride, TE-HCl) release. In vitro cell studies using human umbilical vein blood vessel cell line demonstrated device biocompatibility and Escherichia Coli (E. coli) was selected to demonstrate anti-bacterial function. Overall, a new hybrid engineering platform to prepare customizable and exciting multi-faceted drug release constructs is elucidated.
KW - EHD continuous jetting
KW - Electrospinning
KW - Hybrid system
KW - Rapid drug release
KW - Sustained drug release
UR - http://www.scopus.com/inward/record.url?scp=85043244950&partnerID=8YFLogxK
U2 - 10.1016/j.cej.2018.03.021
DO - 10.1016/j.cej.2018.03.021
M3 - Article
VL - 343
SP - 379
EP - 389
JO - Chemical Engineering Journal
T2 - Chemical Engineering Journal
JF - Chemical Engineering Journal
SN - 1385-8947
ER -