Development of random and ordered composite fiber hybrid technologies for controlled release functions

Baolin Wang, Zeeshan Ahmad, Jie Huang, Jing song Li, Ming Wei Chang

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Fibrous technologies (such as membranes, films, patches and filters) and their enabling engineering platforms have gained considerable interest over the last decade. In this study, novel fibrous constructs from a unique engineering platform were developed based on hybrid electrohydrodynamic (EHD) technology; incorporating functional and bioactive materials within random and aligned fibrous formulation geometries. Complex constructs were engineered using 3D printing (polycaprolactone, PCL, for sustained delivery) and electrospinning (polyvinylpyrrolidone, PVP, for rapid release) in an intercalating material layer-by-layer format using a side-by-side technological approach. Here, structure generation proceeded with deposition of ordered PCL fibers enabling well-defined void size and overall dimension, after which randomly spun PVP fibers formed a construct overcoat (as a membrane). Differences between polymer dissolution rate, hydrophilicity, mechanical properties and functional material hosting (and linked external auxiliary magnetic field trigger) provided opportunities to modulate antibiotic drug (tetracycline hydrochloride, TE-HCl) release. In vitro cell studies using human umbilical vein blood vessel cell line demonstrated device biocompatibility and Escherichia Coli (E. coli) was selected to demonstrate anti-bacterial function. Overall, a new hybrid engineering platform to prepare customizable and exciting multi-faceted drug release constructs is elucidated.

LanguageEnglish
Pages379-389
Number of pages11
JournalChemical Engineering Journal
Volume343
Early online date6 Mar 2018
DOIs
Publication statusPublished - 1 Jul 2018

Fingerprint

engineering
Fibers
Composite materials
drug
membrane
Membranes
Povidone
Polycaprolactone
Electrohydrodynamics
Functional materials
Blood vessels
Hydrophilicity
Electrospinning
Antibiotics
Tetracycline
Biocompatibility
Pharmaceutical Preparations
antibiotics
void
Escherichia coli

Keywords

  • EHD continuous jetting
  • Electrospinning
  • Hybrid system
  • Rapid drug release
  • Sustained drug release

Cite this

Wang, Baolin ; Ahmad, Zeeshan ; Huang, Jie ; Li, Jing song ; Chang, Ming Wei. / Development of random and ordered composite fiber hybrid technologies for controlled release functions. In: Chemical Engineering Journal. 2018 ; Vol. 343. pp. 379-389.
@article{aa590560b4a541c0926c5c339dd5dff4,
title = "Development of random and ordered composite fiber hybrid technologies for controlled release functions",
abstract = "Fibrous technologies (such as membranes, films, patches and filters) and their enabling engineering platforms have gained considerable interest over the last decade. In this study, novel fibrous constructs from a unique engineering platform were developed based on hybrid electrohydrodynamic (EHD) technology; incorporating functional and bioactive materials within random and aligned fibrous formulation geometries. Complex constructs were engineered using 3D printing (polycaprolactone, PCL, for sustained delivery) and electrospinning (polyvinylpyrrolidone, PVP, for rapid release) in an intercalating material layer-by-layer format using a side-by-side technological approach. Here, structure generation proceeded with deposition of ordered PCL fibers enabling well-defined void size and overall dimension, after which randomly spun PVP fibers formed a construct overcoat (as a membrane). Differences between polymer dissolution rate, hydrophilicity, mechanical properties and functional material hosting (and linked external auxiliary magnetic field trigger) provided opportunities to modulate antibiotic drug (tetracycline hydrochloride, TE-HCl) release. In vitro cell studies using human umbilical vein blood vessel cell line demonstrated device biocompatibility and Escherichia Coli (E. coli) was selected to demonstrate anti-bacterial function. Overall, a new hybrid engineering platform to prepare customizable and exciting multi-faceted drug release constructs is elucidated.",
keywords = "EHD continuous jetting, Electrospinning, Hybrid system, Rapid drug release, Sustained drug release",
author = "Baolin Wang and Zeeshan Ahmad and Jie Huang and Li, {Jing song} and Chang, {Ming Wei}",
note = "Ming-Wei was employed in China at the time of acceptance and publication",
year = "2018",
month = "7",
day = "1",
doi = "10.1016/j.cej.2018.03.021",
language = "English",
volume = "343",
pages = "379--389",
journal = "Chemical Engineering Journal",
issn = "1385-8947",
publisher = "Elsevier",

}

Development of random and ordered composite fiber hybrid technologies for controlled release functions. / Wang, Baolin; Ahmad, Zeeshan; Huang, Jie; Li, Jing song; Chang, Ming Wei.

In: Chemical Engineering Journal, Vol. 343, 01.07.2018, p. 379-389.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Development of random and ordered composite fiber hybrid technologies for controlled release functions

AU - Wang, Baolin

AU - Ahmad, Zeeshan

AU - Huang, Jie

AU - Li, Jing song

AU - Chang, Ming Wei

N1 - Ming-Wei was employed in China at the time of acceptance and publication

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Fibrous technologies (such as membranes, films, patches and filters) and their enabling engineering platforms have gained considerable interest over the last decade. In this study, novel fibrous constructs from a unique engineering platform were developed based on hybrid electrohydrodynamic (EHD) technology; incorporating functional and bioactive materials within random and aligned fibrous formulation geometries. Complex constructs were engineered using 3D printing (polycaprolactone, PCL, for sustained delivery) and electrospinning (polyvinylpyrrolidone, PVP, for rapid release) in an intercalating material layer-by-layer format using a side-by-side technological approach. Here, structure generation proceeded with deposition of ordered PCL fibers enabling well-defined void size and overall dimension, after which randomly spun PVP fibers formed a construct overcoat (as a membrane). Differences between polymer dissolution rate, hydrophilicity, mechanical properties and functional material hosting (and linked external auxiliary magnetic field trigger) provided opportunities to modulate antibiotic drug (tetracycline hydrochloride, TE-HCl) release. In vitro cell studies using human umbilical vein blood vessel cell line demonstrated device biocompatibility and Escherichia Coli (E. coli) was selected to demonstrate anti-bacterial function. Overall, a new hybrid engineering platform to prepare customizable and exciting multi-faceted drug release constructs is elucidated.

AB - Fibrous technologies (such as membranes, films, patches and filters) and their enabling engineering platforms have gained considerable interest over the last decade. In this study, novel fibrous constructs from a unique engineering platform were developed based on hybrid electrohydrodynamic (EHD) technology; incorporating functional and bioactive materials within random and aligned fibrous formulation geometries. Complex constructs were engineered using 3D printing (polycaprolactone, PCL, for sustained delivery) and electrospinning (polyvinylpyrrolidone, PVP, for rapid release) in an intercalating material layer-by-layer format using a side-by-side technological approach. Here, structure generation proceeded with deposition of ordered PCL fibers enabling well-defined void size and overall dimension, after which randomly spun PVP fibers formed a construct overcoat (as a membrane). Differences between polymer dissolution rate, hydrophilicity, mechanical properties and functional material hosting (and linked external auxiliary magnetic field trigger) provided opportunities to modulate antibiotic drug (tetracycline hydrochloride, TE-HCl) release. In vitro cell studies using human umbilical vein blood vessel cell line demonstrated device biocompatibility and Escherichia Coli (E. coli) was selected to demonstrate anti-bacterial function. Overall, a new hybrid engineering platform to prepare customizable and exciting multi-faceted drug release constructs is elucidated.

KW - EHD continuous jetting

KW - Electrospinning

KW - Hybrid system

KW - Rapid drug release

KW - Sustained drug release

UR - http://www.scopus.com/inward/record.url?scp=85043244950&partnerID=8YFLogxK

U2 - 10.1016/j.cej.2018.03.021

DO - 10.1016/j.cej.2018.03.021

M3 - Article

VL - 343

SP - 379

EP - 389

JO - Chemical Engineering Journal

T2 - Chemical Engineering Journal

JF - Chemical Engineering Journal

SN - 1385-8947

ER -