Development of drug loaded cardiovascular prosthesis for thrombosis prevention using 3D printing

Juan Domínguez-Robles, Tingjun Shen, Victoria A Cornelius, Francesca Corduas, Elena Mancuso, Ryan F Donnelly, Andriana Margariti, Dimitrios A Lamprou, Eneko Larrañeta

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42 Citations (Scopus)
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Cardiovascular disease (CVD) is a general term for conditions which are the leading cause of death in the world. Quick restoration of tissue perfusion is a key factor to combat these diseases and improve the quality and duration of patients' life. Revascularization techniques include angioplasty, placement of a stent, or surgical bypass grafting. For the latter technique, autologous vessels remain the best clinical option; however, many patients lack suitable autogenous due to previous operations and they are often unsuitable. Therefore, synthetic vascular grafts providing antithrombosis, neointimal hyperplasia inhibition and fast endothelialization are still needed. To address these limitations, 3D printed dipyridamole (DIP) loaded biodegradable vascular grafts were developed. Polycaprolactone (PCL) and DIP were successfully mixed without solvents and then vascular grafts were 3D printed. A mixture of high and low molecular weight PCL was used to better ensure the integration of DIP, which would offer the biological functions required above. Moreover, 3D printing technology provides the ability to fabricate structures of precise geometries from a 3D model, enabling to customize the vascular grafts' shape or size. The produced vascular grafts were fully characterized through multiple techniques and the last step was to evaluate their drug release, antiplatelet effect and cytocompatibility. The results suggested that DIP was properly mixed and integrated within the PCL matrix. Moreover, these materials can provide a sustained and linear drug release without any obvious burst release, or any faster initial release rates for 30 days. Compared to PCL alone, a clear reduced platelet deposition in all the DIP-loaded vascular grafts was evidenced. The hemolysis percentage of both materials PCL alone and PCL containing 20% DIP were lower than 4%. Moreover, PCL and 20% DIP loaded grafts were able to provide a supportive environment for cellular attachment, viability, and growth. [Abstract copyright: Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.]
Original languageEnglish
Article number112375
Pages (from-to)112375
Number of pages1
JournalMaterials Science and Engineering: C
Early online date14 Aug 2021
Publication statusPublished (in print/issue) - 1 Oct 2021

Bibliographical note

Funding Information:
This work was financially supported by the Wellcome Trust ( UNS40040 ).

Publisher Copyright:
© 2021 The Authors

Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.


  • 3D printing
  • Polycaprolactone
  • Blood Vessel Prosthesis
  • Polyesters
  • Anticoagulants
  • Printing, Three-Dimensional
  • Thrombosis - prevention & control
  • Biodegradable vascular grafts
  • Dipyridamole
  • Antithrombotic effect
  • Pharmaceutical Preparations
  • Humans
  • Thrombosis
  • 3D Printing
  • Antithrombotic Effect
  • Biodegradable Vascular Grafts
  • Thrombosis/prevention & control


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