Development of a Biodegradable Subcutaneous Implant for Prolonged Drug Delivery Using 3D Printing

Sarah Stewart, Juan Domínguez-Robles, Victoria J McIlorum, Elena Mancuso, Dimitrios Lamprou, Ryan F. Donnelly, Eneko Larraneta

Research output: Contribution to journalArticle

Abstract

Implantable drug delivery devices offer many advantages over other routes of drug delivery. Most significantly, the delivery of lower doses of drug, thus, potentially reducing side-effects and improving patient compliance. Three dimensional (3D) printing is a flexible technique, which has been subject to increasing interest in the past few years, especially in the area of medical devices. The present work focussed on the use of 3D printing as a tool to manufacture implantable drug delivery devices to deliver a range of model compounds (methylene blue, ibuprofen sodium and ibuprofen acid) in two in vitro models. Five implant designs were produced, and the release rate varied, depending on the implant design and the drug properties. Additionally, a rate controlling membrane was produced, which further prolonged the release from the produced implants, signalling the potential use of these devices for chronic conditions.
LanguageEnglish
Number of pages16
JournalPharmaceutics
Volume12
Issue number2
DOIs
Publication statusPublished - 28 Jan 2020

Fingerprint

Absorbable Implants
Equipment and Supplies
Ibuprofen
Pharmaceutical Preparations
Drug Implants
Drug Design
Methylene Blue
Patient Compliance
Sodium
Acids
Membranes
Three Dimensional Printing

Keywords

  • implantable devices
  • subcutaneous
  • biodegradable
  • 3D printing
  • prolonged drug delivery

Cite this

Stewart, S., Domínguez-Robles, J., McIlorum, V. J., Mancuso, E., Lamprou, D., Donnelly, R. F., & Larraneta, E. (2020). Development of a Biodegradable Subcutaneous Implant for Prolonged Drug Delivery Using 3D Printing. Pharmaceutics, 12(2). https://doi.org/10.3390/pharmaceutics12020105
Stewart, Sarah ; Domínguez-Robles, Juan ; McIlorum, Victoria J ; Mancuso, Elena ; Lamprou, Dimitrios ; Donnelly, Ryan F. ; Larraneta, Eneko. / Development of a Biodegradable Subcutaneous Implant for Prolonged Drug Delivery Using 3D Printing. In: Pharmaceutics. 2020 ; Vol. 12, No. 2.
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Stewart, S, Domínguez-Robles, J, McIlorum, VJ, Mancuso, E, Lamprou, D, Donnelly, RF & Larraneta, E 2020, 'Development of a Biodegradable Subcutaneous Implant for Prolonged Drug Delivery Using 3D Printing', Pharmaceutics, vol. 12, no. 2. https://doi.org/10.3390/pharmaceutics12020105

Development of a Biodegradable Subcutaneous Implant for Prolonged Drug Delivery Using 3D Printing. / Stewart, Sarah; Domínguez-Robles, Juan; McIlorum, Victoria J; Mancuso, Elena; Lamprou, Dimitrios; Donnelly, Ryan F.; Larraneta, Eneko.

In: Pharmaceutics, Vol. 12, No. 2, 28.01.2020.

Research output: Contribution to journalArticle

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