Detraining Effects on Musculoskeletal Parameters in Early Postmenopausal Osteopenic Women: 3-Month Follow-Up of the Randomized Controlled ACTLIFE Study

Wolfgang Kemmler, Michael Hettchen, Matthias Kohl, Marie Murphy, Laura Bragonzoni, Mikko Julin, Tapani Risto, Simon von Stengel

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6 Citations (Scopus)
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Periods of absence from supervised group exercise while maintaining physical activity might be a frequent pattern in adults' exercise habits. The aim of the present study was to determine detraining effects on musculoskeletal outcomes after a 3-month detraining period in early post-menopausal, osteopenic women. Due to the COVID-19 pandemic, we terminated the 18-month randomized controlled ACTLIFE exercise intervention immediately after the 13-month follow-up assessment. This put an abrupt stop to the high-intensity aerobic and resistance group exercise sessions undertaken three times per week by the exercise group (EG: n = 27) and the gentle exercise program performed once per week for the attention control group (CG: n = 27); but both groups were permitted to conduct individual outdoor activity for the 3-month lock-down period. Study endpoints were lean body mass (LBM), bone mineral density (BMD) at the lumbar spine (LS), maximum hip-/leg extension strength and power. Detraining-induced reductions of LBM, hip/leg strength and power (but not BMD-LS) were significantly greater (p < 0.001 to p = 0.044) compared with the CG. Significant exercise effects, i.e. differences between EG and CG, present after 13 months of exercise, were lost after 3 months of detraining for LBM (p = 0.157) and BMD-LS (p = 0.065), but not for strength (p < 0.001) and power (p < 0.001). Of note, self-reported individual outdoor activities and exercise increased by about 40% in both groups during the lock-down period. Three months' absence from a supervised group exercise protocol resulted in considerable detraining effects for musculoskeletal parameters. Thus, exercise programs for adults should be continuous rather than intermittent. Trial registration number: NCT04420806, 06.05.2020.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalCalcified Tissue International
Issue number1
Early online date12 Mar 2021
Publication statusPublished (in print/issue) - 31 Jul 2021

Bibliographical note

Funding Information:
Open Access funding enabled and organized by Projekt DEAL. This study is one of the intellectual outputs of the project “ACTLIFE-Physical activity the tool to improve the quality of life in osteoporosis people” and had grant support from the European Union’s Erasmus Plus Sport program under grant agreement No. 2017-2128/001-001.

Publisher Copyright:
© 2021, The Author(s).


  • Original Research
  • Detraining
  • High-intensity exercise
  • Bone mineral density
  • Lean body mass
  • Strength and power


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