Determinants of pp-dichlorodiphenyldichloroethane (DDE) concentration in adipose tissue in women from five European cities

MI Sanz-Gallardo, E Guallar, P Van't Veer, MP Longnecker, JJ Strain, BC Martin, AFM Kardinaal, J Fernandez-Crehuet, M Thamm, L Kohlmeier, FJ Kok, JM Martin-Moreno

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Abstract

To identify the determinants of pp-dichlorodiphenyldichloroethane (pp-DDE) in adipose tissue in subjects who participated in a cross-sectional study, we analyzed fatty acids, antioxidants, and pp-DDE in aspirates of adipose tissue of 328 postmenopausal women from 5 European countries. The overall mean of p,p'-DDE concentration was 1.66 mu g/g of fatty acids (95% confidence interval = 1.46, 1.88). In a multiple-regression analysis, the main predictors of log(10)(pp-DDE) were center of recruitment (p <.0001), adipose arachidic acid (p =.001), and adipose retinol (p =.04). These factors explained 14.9% of the overall variability of log(10)(pp-DDE), In our subjects, adipose tissue pp-DDE concentrations were only weakly related with biomarkers reflecting intake of fish and other foods. This result is consistent with the notion that p,p'-DDE exists in different foods and, given the widespread contamination of the food chain, is relatively evenly distributed among foods.
Original languageEnglish
Pages (from-to)277-283
JournalArchives of Environmental Health
Volume54
Issue number4
Publication statusPublished - Jul 1999

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    Sanz-Gallardo, MI., Guallar, E., Van't Veer, P., Longnecker, MP., Strain, JJ., Martin, BC., Kardinaal, AFM., Fernandez-Crehuet, J., Thamm, M., Kohlmeier, L., Kok, FJ., & Martin-Moreno, JM. (1999). Determinants of pp-dichlorodiphenyldichloroethane (DDE) concentration in adipose tissue in women from five European cities. Archives of Environmental Health, 54(4), 277-283.