Determinants of pp-dichlorodiphenyldichloroethane (DDE) concentration in adipose tissue in women from five European cities

MI Sanz-Gallardo, E Guallar, P Van't Veer, MP Longnecker, JJ Strain, BC Martin, AFM Kardinaal, J Fernandez-Crehuet, M Thamm, L Kohlmeier, FJ Kok, JM Martin-Moreno

Research output: Contribution to journalArticle

Abstract

To identify the determinants of pp-dichlorodiphenyldichloroethane (pp-DDE) in adipose tissue in subjects who participated in a cross-sectional study, we analyzed fatty acids, antioxidants, and pp-DDE in aspirates of adipose tissue of 328 postmenopausal women from 5 European countries. The overall mean of p,p'-DDE concentration was 1.66 mu g/g of fatty acids (95% confidence interval = 1.46, 1.88). In a multiple-regression analysis, the main predictors of log(10)(pp-DDE) were center of recruitment (p <.0001), adipose arachidic acid (p =.001), and adipose retinol (p =.04). These factors explained 14.9% of the overall variability of log(10)(pp-DDE), In our subjects, adipose tissue pp-DDE concentrations were only weakly related with biomarkers reflecting intake of fish and other foods. This result is consistent with the notion that p,p'-DDE exists in different foods and, given the widespread contamination of the food chain, is relatively evenly distributed among foods.
LanguageEnglish
Pages277-283
JournalARCHIVES OF ENVIRONMENTAL HEALTH
Volume54
Issue number4
Publication statusPublished - Jul 1999

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Dichlorodiphenyldichloroethane
Adipose Tissue
Food
Fatty Acids
Food Chain
Vitamin A
Fishes
Cross-Sectional Studies
Antioxidants
Biomarkers
Regression Analysis
Confidence Intervals

Cite this

Sanz-Gallardo, MI., Guallar, E., Van't Veer, P., Longnecker, MP., Strain, JJ., Martin, BC., ... Martin-Moreno, JM. (1999). Determinants of pp-dichlorodiphenyldichloroethane (DDE) concentration in adipose tissue in women from five European cities. 54(4), 277-283.
Sanz-Gallardo, MI ; Guallar, E ; Van't Veer, P ; Longnecker, MP ; Strain, JJ ; Martin, BC ; Kardinaal, AFM ; Fernandez-Crehuet, J ; Thamm, M ; Kohlmeier, L ; Kok, FJ ; Martin-Moreno, JM. / Determinants of pp-dichlorodiphenyldichloroethane (DDE) concentration in adipose tissue in women from five European cities. 1999 ; Vol. 54, No. 4. pp. 277-283.
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abstract = "To identify the determinants of pp-dichlorodiphenyldichloroethane (pp-DDE) in adipose tissue in subjects who participated in a cross-sectional study, we analyzed fatty acids, antioxidants, and pp-DDE in aspirates of adipose tissue of 328 postmenopausal women from 5 European countries. The overall mean of p,p'-DDE concentration was 1.66 mu g/g of fatty acids (95{\%} confidence interval = 1.46, 1.88). In a multiple-regression analysis, the main predictors of log(10)(pp-DDE) were center of recruitment (p <.0001), adipose arachidic acid (p =.001), and adipose retinol (p =.04). These factors explained 14.9{\%} of the overall variability of log(10)(pp-DDE), In our subjects, adipose tissue pp-DDE concentrations were only weakly related with biomarkers reflecting intake of fish and other foods. This result is consistent with the notion that p,p'-DDE exists in different foods and, given the widespread contamination of the food chain, is relatively evenly distributed among foods.",
author = "MI Sanz-Gallardo and E Guallar and {Van't Veer}, P and MP Longnecker and JJ Strain and BC Martin and AFM Kardinaal and J Fernandez-Crehuet and M Thamm and L Kohlmeier and FJ Kok and JM Martin-Moreno",
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Sanz-Gallardo, MI, Guallar, E, Van't Veer, P, Longnecker, MP, Strain, JJ, Martin, BC, Kardinaal, AFM, Fernandez-Crehuet, J, Thamm, M, Kohlmeier, L, Kok, FJ & Martin-Moreno, JM 1999, 'Determinants of pp-dichlorodiphenyldichloroethane (DDE) concentration in adipose tissue in women from five European cities', vol. 54, no. 4, pp. 277-283.

Determinants of pp-dichlorodiphenyldichloroethane (DDE) concentration in adipose tissue in women from five European cities. / Sanz-Gallardo, MI; Guallar, E; Van't Veer, P; Longnecker, MP; Strain, JJ; Martin, BC; Kardinaal, AFM; Fernandez-Crehuet, J; Thamm, M; Kohlmeier, L; Kok, FJ; Martin-Moreno, JM.

Vol. 54, No. 4, 07.1999, p. 277-283.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Determinants of pp-dichlorodiphenyldichloroethane (DDE) concentration in adipose tissue in women from five European cities

AU - Sanz-Gallardo, MI

AU - Guallar, E

AU - Van't Veer, P

AU - Longnecker, MP

AU - Strain, JJ

AU - Martin, BC

AU - Kardinaal, AFM

AU - Fernandez-Crehuet, J

AU - Thamm, M

AU - Kohlmeier, L

AU - Kok, FJ

AU - Martin-Moreno, JM

PY - 1999/7

Y1 - 1999/7

N2 - To identify the determinants of pp-dichlorodiphenyldichloroethane (pp-DDE) in adipose tissue in subjects who participated in a cross-sectional study, we analyzed fatty acids, antioxidants, and pp-DDE in aspirates of adipose tissue of 328 postmenopausal women from 5 European countries. The overall mean of p,p'-DDE concentration was 1.66 mu g/g of fatty acids (95% confidence interval = 1.46, 1.88). In a multiple-regression analysis, the main predictors of log(10)(pp-DDE) were center of recruitment (p <.0001), adipose arachidic acid (p =.001), and adipose retinol (p =.04). These factors explained 14.9% of the overall variability of log(10)(pp-DDE), In our subjects, adipose tissue pp-DDE concentrations were only weakly related with biomarkers reflecting intake of fish and other foods. This result is consistent with the notion that p,p'-DDE exists in different foods and, given the widespread contamination of the food chain, is relatively evenly distributed among foods.

AB - To identify the determinants of pp-dichlorodiphenyldichloroethane (pp-DDE) in adipose tissue in subjects who participated in a cross-sectional study, we analyzed fatty acids, antioxidants, and pp-DDE in aspirates of adipose tissue of 328 postmenopausal women from 5 European countries. The overall mean of p,p'-DDE concentration was 1.66 mu g/g of fatty acids (95% confidence interval = 1.46, 1.88). In a multiple-regression analysis, the main predictors of log(10)(pp-DDE) were center of recruitment (p <.0001), adipose arachidic acid (p =.001), and adipose retinol (p =.04). These factors explained 14.9% of the overall variability of log(10)(pp-DDE), In our subjects, adipose tissue pp-DDE concentrations were only weakly related with biomarkers reflecting intake of fish and other foods. This result is consistent with the notion that p,p'-DDE exists in different foods and, given the widespread contamination of the food chain, is relatively evenly distributed among foods.

M3 - Article

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SP - 277

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Sanz-Gallardo MI, Guallar E, Van't Veer P, Longnecker MP, Strain JJ, Martin BC et al. Determinants of pp-dichlorodiphenyldichloroethane (DDE) concentration in adipose tissue in women from five European cities. 1999 Jul;54(4):277-283.