Detecting Change in Conjunctival Hyperemia Using a Pixel Densitometry Index

Vito Romano, Bernhard Steger, Matthias Brunner, Abigail Kaye, Yalin Zheng, Colin Willoughby, Stephen B. Kaye

    Research output: Contribution to journalArticle

    Abstract

    To investigate a pixel densitometry index (PDI) for measuring ocular surface inflammation (OSI).METHODS:Efron's grading was performed by two independent observers. Color photographs and indocyanine green angiography were undertaken before and after instillation of phenylephrine (PE) hydrochloride 2.5%.RESULTS:A total of 15 patients with and 10 without OSI were included. PDI before and after PE was 73.29 ± 30.71 and 50.87 ± 17.46 (p = 0.036) in patients with inflammation and 52.86 ± 16.90 and 39.63 ± 12.04 (p = 0.0024) in those without OSI. The reduction in Efron grades following PE was 25% (mean 0.46 ± 0.50, median 0.50; p <0.01). The coefficient of variation pre- and post-PE was lower using the PDI (42% and 50%) than with the Efron grades (59% and 72%).CONCLUSION:The PDI allows the objective detection of change in conjunctival hyperemia with potential direct applicability to noninvasive angiography such as optical coherence tomography-based angiography.
    LanguageEnglish
    Pages1-6
    JournalOcular Immunology and Inflammation
    Volumeonline
    DOIs
    Publication statusAccepted/In press - 28 Sep 2017

    Fingerprint

    Densitometry
    Hyperemia
    Phenylephrine
    Inflammation
    Angiography
    Indocyanine Green
    Optical Coherence Tomography
    Color

    Keywords

    • Angiography
    • conjunctival inflammation
    • monitoring
    • pixel densitometry

    Cite this

    Romano, Vito ; Steger, Bernhard ; Brunner, Matthias ; Kaye, Abigail ; Zheng, Yalin ; Willoughby, Colin ; Kaye, Stephen B. / Detecting Change in Conjunctival Hyperemia Using a Pixel Densitometry Index. In: Ocular Immunology and Inflammation. 2017 ; Vol. online. pp. 1-6.
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    title = "Detecting Change in Conjunctival Hyperemia Using a Pixel Densitometry Index",
    abstract = "To investigate a pixel densitometry index (PDI) for measuring ocular surface inflammation (OSI).METHODS:Efron's grading was performed by two independent observers. Color photographs and indocyanine green angiography were undertaken before and after instillation of phenylephrine (PE) hydrochloride 2.5{\%}.RESULTS:A total of 15 patients with and 10 without OSI were included. PDI before and after PE was 73.29 ± 30.71 and 50.87 ± 17.46 (p = 0.036) in patients with inflammation and 52.86 ± 16.90 and 39.63 ± 12.04 (p = 0.0024) in those without OSI. The reduction in Efron grades following PE was 25{\%} (mean 0.46 ± 0.50, median 0.50; p <0.01). The coefficient of variation pre- and post-PE was lower using the PDI (42{\%} and 50{\%}) than with the Efron grades (59{\%} and 72{\%}).CONCLUSION:The PDI allows the objective detection of change in conjunctival hyperemia with potential direct applicability to noninvasive angiography such as optical coherence tomography-based angiography.",
    keywords = "Angiography, conjunctival inflammation, monitoring, pixel densitometry",
    author = "Vito Romano and Bernhard Steger and Matthias Brunner and Abigail Kaye and Yalin Zheng and Colin Willoughby and Kaye, {Stephen B.}",
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    Detecting Change in Conjunctival Hyperemia Using a Pixel Densitometry Index. / Romano, Vito; Steger, Bernhard; Brunner, Matthias; Kaye, Abigail; Zheng, Yalin; Willoughby, Colin; Kaye, Stephen B.

    In: Ocular Immunology and Inflammation, Vol. online, 28.09.2017, p. 1-6.

    Research output: Contribution to journalArticle

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    AU - Romano, Vito

    AU - Steger, Bernhard

    AU - Brunner, Matthias

    AU - Kaye, Abigail

    AU - Zheng, Yalin

    AU - Willoughby, Colin

    AU - Kaye, Stephen B.

    PY - 2017/9/28

    Y1 - 2017/9/28

    N2 - To investigate a pixel densitometry index (PDI) for measuring ocular surface inflammation (OSI).METHODS:Efron's grading was performed by two independent observers. Color photographs and indocyanine green angiography were undertaken before and after instillation of phenylephrine (PE) hydrochloride 2.5%.RESULTS:A total of 15 patients with and 10 without OSI were included. PDI before and after PE was 73.29 ± 30.71 and 50.87 ± 17.46 (p = 0.036) in patients with inflammation and 52.86 ± 16.90 and 39.63 ± 12.04 (p = 0.0024) in those without OSI. The reduction in Efron grades following PE was 25% (mean 0.46 ± 0.50, median 0.50; p <0.01). The coefficient of variation pre- and post-PE was lower using the PDI (42% and 50%) than with the Efron grades (59% and 72%).CONCLUSION:The PDI allows the objective detection of change in conjunctival hyperemia with potential direct applicability to noninvasive angiography such as optical coherence tomography-based angiography.

    AB - To investigate a pixel densitometry index (PDI) for measuring ocular surface inflammation (OSI).METHODS:Efron's grading was performed by two independent observers. Color photographs and indocyanine green angiography were undertaken before and after instillation of phenylephrine (PE) hydrochloride 2.5%.RESULTS:A total of 15 patients with and 10 without OSI were included. PDI before and after PE was 73.29 ± 30.71 and 50.87 ± 17.46 (p = 0.036) in patients with inflammation and 52.86 ± 16.90 and 39.63 ± 12.04 (p = 0.0024) in those without OSI. The reduction in Efron grades following PE was 25% (mean 0.46 ± 0.50, median 0.50; p <0.01). The coefficient of variation pre- and post-PE was lower using the PDI (42% and 50%) than with the Efron grades (59% and 72%).CONCLUSION:The PDI allows the objective detection of change in conjunctival hyperemia with potential direct applicability to noninvasive angiography such as optical coherence tomography-based angiography.

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