Detecting Change in Conjunctival Hyperemia Using a Pixel Densitometry Index

Vito Romano, Bernhard Steger, Matthias Brunner, Abigail Kaye, Yalin Zheng, Colin Willoughby, Stephen B. Kaye

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)


    To investigate a pixel densitometry index (PDI) for measuring ocular surface inflammation (OSI).METHODS:Efron's grading was performed by two independent observers. Color photographs and indocyanine green angiography were undertaken before and after instillation of phenylephrine (PE) hydrochloride 2.5%.RESULTS:A total of 15 patients with and 10 without OSI were included. PDI before and after PE was 73.29 ± 30.71 and 50.87 ± 17.46 (p = 0.036) in patients with inflammation and 52.86 ± 16.90 and 39.63 ± 12.04 (p = 0.0024) in those without OSI. The reduction in Efron grades following PE was 25% (mean 0.46 ± 0.50, median 0.50; p <0.01). The coefficient of variation pre- and post-PE was lower using the PDI (42% and 50%) than with the Efron grades (59% and 72%).CONCLUSION:The PDI allows the objective detection of change in conjunctival hyperemia with potential direct applicability to noninvasive angiography such as optical coherence tomography-based angiography.
    Original languageEnglish
    Pages (from-to)1-6
    JournalOcular Immunology and Inflammation
    Publication statusAccepted/In press - 28 Sept 2017


    • Angiography
    • conjunctival inflammation
    • monitoring
    • pixel densitometry


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