Abstract
Although microneedle array patch (MAP) technology is reaching ever closer to regulatory approval, it remains imperative
that approaches to further improve patient acceptance are still explored. Addressing this perception, a water-flled reservoir
was incorporated into a hydrogel-forming MAP system to provide a novel feedback mechanism. To confrm successful MAP
skin insertion, the end user would both hear and feel the rupture of the water-flled reservoir. Interestingly, a 50-µL waterflled reservoir ruptured at 30.27±0.39 N, which has previously been shown as the mean application force for MN insertion
in human subjects following appropriate instruction. Importantly, no signifcant diference in % cumulative permeation of
FITC-dextran 10 kDa and fuorescein sodium after 24 h was observed between a 50-µL reservoir and the current method of
application that has been successfully used in both in vitro and in vivo studies (p>0.05). Therefore, as drug delivery was not
afected, this proof-of-concept study has shown that a water-flled reservoir feedback mechanism has the potential to serve
as a viable tool for consistent MAP skin insertion.
that approaches to further improve patient acceptance are still explored. Addressing this perception, a water-flled reservoir
was incorporated into a hydrogel-forming MAP system to provide a novel feedback mechanism. To confrm successful MAP
skin insertion, the end user would both hear and feel the rupture of the water-flled reservoir. Interestingly, a 50-µL waterflled reservoir ruptured at 30.27±0.39 N, which has previously been shown as the mean application force for MN insertion
in human subjects following appropriate instruction. Importantly, no signifcant diference in % cumulative permeation of
FITC-dextran 10 kDa and fuorescein sodium after 24 h was observed between a 50-µL reservoir and the current method of
application that has been successfully used in both in vitro and in vivo studies (p>0.05). Therefore, as drug delivery was not
afected, this proof-of-concept study has shown that a water-flled reservoir feedback mechanism has the potential to serve
as a viable tool for consistent MAP skin insertion.
Original language | English |
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Pages (from-to) | 838-850 |
Number of pages | 13 |
Journal | Drug Delivery and Translational Research |
Volume | 12 |
Early online date | 31 Jul 2021 |
DOIs | |
Publication status | Published (in print/issue) - 30 Apr 2022 |
Keywords
- Microneedle array patch (MAP)
- Water-flled polymeric reservoir (PR)
- Feedback mechanism
- Skin insertion