Designer fibers from 2D to 3D – Simultaneous and controlled engineering of morphology, shape and size

Zhi Cheng Yao, Chunchen Zhang, Zeeshan Ahmad, Jie Huang, Jing Song Li, Ming Wei Chang

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Topography and surface morphology of micrometer and nanometer scaled fibrous biomaterials are crucial for bioactive component encapsulation, release, promoting cell proliferation and interaction within biological environment. Specifically, for drug delivery and tissue repair applications, surface engineering provides control on both aspects in tandem. In this study, the bioactive component (ganoderma lucidum spore polysaccharide (GLSP)) was loaded into zein prolamine (ZP) fiber matrices via coaxial electrospinning (CES) technique. During the CES process, various outer layer enveloping fluids were used to modulate fiber topography in-situ (from 2D to 3D). SEM and water contact angle tests indicate enveloping media impact electrospun fiber diameter (ranging from 400 nm to 3.0 μm) and morphologies (from flat ribbon-like to solid cylindrical structures), with the latter impacting GLSP release profile. Furthermore, CCK-8 assay assessment indicates fibroblast cell proliferation (L929 cell line), while cell extension was also observed for modified ZP fibers. The results demonstrate potential applications of modified fiber morphologies, which are tailored in-situ without impacting chemical stability and encapsulation.

LanguageEnglish
Pages89-98
Number of pages10
JournalChemical Engineering Journal
Volume334
Early online date9 Oct 2017
DOIs
Publication statusPublished - 15 Feb 2018

Fingerprint

engineering
Zein
Fibers
Phenylpropanolamine
encapsulation
Cell proliferation
Electrospinning
Polysaccharides
Encapsulation
polysaccharide
Topography
spore
topography
Sincalide
Chemical stability
Biocompatible Materials
Fibroblasts
Drug delivery
Biomaterials
repair

Keywords

  • Biocompatibility
  • Coaxial electrospinning
  • Fiber morphology
  • Ganoderma lucidum spore polysaccharide
  • Zein prolamine

Cite this

Yao, Zhi Cheng ; Zhang, Chunchen ; Ahmad, Zeeshan ; Huang, Jie ; Li, Jing Song ; Chang, Ming Wei. / Designer fibers from 2D to 3D – Simultaneous and controlled engineering of morphology, shape and size. In: Chemical Engineering Journal. 2018 ; Vol. 334. pp. 89-98.
@article{08fee5392c3f404bae2ed823bc1cbb30,
title = "Designer fibers from 2D to 3D – Simultaneous and controlled engineering of morphology, shape and size",
abstract = "Topography and surface morphology of micrometer and nanometer scaled fibrous biomaterials are crucial for bioactive component encapsulation, release, promoting cell proliferation and interaction within biological environment. Specifically, for drug delivery and tissue repair applications, surface engineering provides control on both aspects in tandem. In this study, the bioactive component (ganoderma lucidum spore polysaccharide (GLSP)) was loaded into zein prolamine (ZP) fiber matrices via coaxial electrospinning (CES) technique. During the CES process, various outer layer enveloping fluids were used to modulate fiber topography in-situ (from 2D to 3D). SEM and water contact angle tests indicate enveloping media impact electrospun fiber diameter (ranging from 400 nm to 3.0 μm) and morphologies (from flat ribbon-like to solid cylindrical structures), with the latter impacting GLSP release profile. Furthermore, CCK-8 assay assessment indicates fibroblast cell proliferation (L929 cell line), while cell extension was also observed for modified ZP fibers. The results demonstrate potential applications of modified fiber morphologies, which are tailored in-situ without impacting chemical stability and encapsulation.",
keywords = "Biocompatibility, Coaxial electrospinning, Fiber morphology, Ganoderma lucidum spore polysaccharide, Zein prolamine",
author = "Yao, {Zhi Cheng} and Chunchen Zhang and Zeeshan Ahmad and Jie Huang and Li, {Jing Song} and Chang, {Ming Wei}",
note = "Ming-Wei was employed in China at the time of acceptance and publication",
year = "2018",
month = "2",
day = "15",
doi = "10.1016/j.cej.2017.10.033",
language = "English",
volume = "334",
pages = "89--98",
journal = "Chemical Engineering Journal",
issn = "1385-8947",
publisher = "Elsevier",

}

Designer fibers from 2D to 3D – Simultaneous and controlled engineering of morphology, shape and size. / Yao, Zhi Cheng; Zhang, Chunchen; Ahmad, Zeeshan; Huang, Jie; Li, Jing Song; Chang, Ming Wei.

In: Chemical Engineering Journal, Vol. 334, 15.02.2018, p. 89-98.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Designer fibers from 2D to 3D – Simultaneous and controlled engineering of morphology, shape and size

AU - Yao, Zhi Cheng

AU - Zhang, Chunchen

AU - Ahmad, Zeeshan

AU - Huang, Jie

AU - Li, Jing Song

AU - Chang, Ming Wei

N1 - Ming-Wei was employed in China at the time of acceptance and publication

PY - 2018/2/15

Y1 - 2018/2/15

N2 - Topography and surface morphology of micrometer and nanometer scaled fibrous biomaterials are crucial for bioactive component encapsulation, release, promoting cell proliferation and interaction within biological environment. Specifically, for drug delivery and tissue repair applications, surface engineering provides control on both aspects in tandem. In this study, the bioactive component (ganoderma lucidum spore polysaccharide (GLSP)) was loaded into zein prolamine (ZP) fiber matrices via coaxial electrospinning (CES) technique. During the CES process, various outer layer enveloping fluids were used to modulate fiber topography in-situ (from 2D to 3D). SEM and water contact angle tests indicate enveloping media impact electrospun fiber diameter (ranging from 400 nm to 3.0 μm) and morphologies (from flat ribbon-like to solid cylindrical structures), with the latter impacting GLSP release profile. Furthermore, CCK-8 assay assessment indicates fibroblast cell proliferation (L929 cell line), while cell extension was also observed for modified ZP fibers. The results demonstrate potential applications of modified fiber morphologies, which are tailored in-situ without impacting chemical stability and encapsulation.

AB - Topography and surface morphology of micrometer and nanometer scaled fibrous biomaterials are crucial for bioactive component encapsulation, release, promoting cell proliferation and interaction within biological environment. Specifically, for drug delivery and tissue repair applications, surface engineering provides control on both aspects in tandem. In this study, the bioactive component (ganoderma lucidum spore polysaccharide (GLSP)) was loaded into zein prolamine (ZP) fiber matrices via coaxial electrospinning (CES) technique. During the CES process, various outer layer enveloping fluids were used to modulate fiber topography in-situ (from 2D to 3D). SEM and water contact angle tests indicate enveloping media impact electrospun fiber diameter (ranging from 400 nm to 3.0 μm) and morphologies (from flat ribbon-like to solid cylindrical structures), with the latter impacting GLSP release profile. Furthermore, CCK-8 assay assessment indicates fibroblast cell proliferation (L929 cell line), while cell extension was also observed for modified ZP fibers. The results demonstrate potential applications of modified fiber morphologies, which are tailored in-situ without impacting chemical stability and encapsulation.

KW - Biocompatibility

KW - Coaxial electrospinning

KW - Fiber morphology

KW - Ganoderma lucidum spore polysaccharide

KW - Zein prolamine

UR - http://www.scopus.com/inward/record.url?scp=85034045979&partnerID=8YFLogxK

U2 - 10.1016/j.cej.2017.10.033

DO - 10.1016/j.cej.2017.10.033

M3 - Article

VL - 334

SP - 89

EP - 98

JO - Chemical Engineering Journal

T2 - Chemical Engineering Journal

JF - Chemical Engineering Journal

SN - 1385-8947

ER -