Design, Synthesis, Antibacterial Activity, and Molecular Docking Studies of Novel Hybrid 1,3-Thiazine-1,3,5-Triazine Derivatives as Potential Bacterial Translation Inhibitor

Udaya P. Singh, Manish Pathak, Vaibhav Dubey, Hans R. Bhat, Prashant Gahtori, Ramendra K. Singh

Research output: Contribution to journalArticlepeer-review

Abstract

Some novel hybrid 1,3-thiazine-1,3,5-triazine derivatives were synthesized and tested for antibacterial activity. Compounds 8c and 8f were found active against Gram positive and Gram negative microorganisms. Molecular docking studies have been performed on eubacterial ribosomal decoding A site (Escherichia coli 16S rRNA A site) to rationalize the probable mode of action, binding affinity, and orientation of the molecules at the active site of receptor. The structures of all these newly synthesized compounds were confirmed by their elemental analyses and spectral data techniques viz. IR, 1H NMR, 13C NMR, and mass.
Original languageEnglish
Pages (from-to)572-583
Number of pages12
JournalChemical Biology and Drug Design
Volume80
Issue number4
DOIs
Publication statusPublished - 1 Oct 2012

Keywords

  • 1,3,5-Triazine
  • 1,3-thiazine
  • antibacterial
  • docking
  • translation inhibition

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