Abstract
Carbon loaded polystyrene microneedle patches have been prepared using silicone micro-moulding techniques and the ability of the needles to serve as viable transdermal sensors has been evaluated. The population of quinone groups at the interface of the embedded carbon nanoparticles was increased through anodisation and their pH dependent redox transitions exploited as the basis of a reagentless pH sensor. The peak position of the quinone oxidation process was found to shift in accordance with Nernstian behaviour and the influence of penetration depth on response has been investigated. The analytical applicability of the microneedle electrode patch was critically evaluated through using tomato skin as model transdermal skin mimic. Despite the increased complexity of the matrix, the microneedle sensor response was found to compare favourably with conventional/commercial pH probes.
Original language | English |
---|---|
Pages (from-to) | 340-346 |
Number of pages | 7 |
Journal | Materials Chemistry and Physics |
Volume | 227 |
Early online date | 23 Jan 2019 |
DOIs | |
Publication status | Published (in print/issue) - 1 Apr 2019 |
Keywords
- Microneedle
- pH
- Transdermal
- Sensor
- Quinones
- Composite
Fingerprint
Dive into the research topics of 'Design of Composite Microneedle Sensor Systems for the Measurement of Transdermal pH'. Together they form a unique fingerprint.Profiles
-
James Davis
- School of Engineering - Professor
- Faculty Of Computing, Eng. & Built Env. - Full Professor
Person: Academic