To realize a programmed build up of DNA objects, devices,and materials, a systematization of the principles that formthe basis of control for the assembly process is necessary. Thusfar the discovery of four-stranded DNA architecturesdenominated G quadruplexes was either serendipitous orthrough coincidental emergence. Herein we utilize a rationalapproach for the design of G quadruplexes based on the twostatedisposition of the glycosidic bond angle.
Webba da Silva, M., Trajkovski, M., Sannohe, Y., Hessari, N., Sugiyama, H., & Plavec, J. (2009). Design of a G-Quadruplex Topology through Glycosidic Bond Angles. Angewandte Chemie International Edition, 48. https://doi.org/10.1002/anie.200902454