Design of a G-Quadruplex Topology through Glycosidic Bond Angles

Mateus Webba da Silva, Marko Trajkovski, Yuta Sannohe, Nason Hessari, Hiroshi Sugiyama, Janez Plavec

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

To realize a programmed build up of DNA objects, devices,and materials, a systematization of the principles that formthe basis of control for the assembly process is necessary. Thusfar the discovery of four-stranded DNA architecturesdenominated G quadruplexes was either serendipitous orthrough coincidental emergence. Herein we utilize a rationalapproach for the design of G quadruplexes based on the twostatedisposition of the glycosidic bond angle.
Original languageEnglish
JournalAngewandte Chemie International Edition
Volume48
DOIs
Publication statusPublished - 2009

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