Deformation velocity imaging using optical coherence tomography and its applications to the cornea

Samuel Lawman, Peter W. Madden, Vito Romano, Yue Dong, Sharon Mason, Bryan M. Williams, Stephen B. Kaye, Colin Willoughby, Simon P. Harding, Yao-Chun Shen, Yalin Zheng

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    Optical coherence tomography (OCT) can monitor human donor corneas non-invasively during the de-swelling process following storage for corneal transplantation, but currently only resultant thickness as a function of time is extracted. To visualize and quantify the mechanism of de-swelling, we present a method exploiting the nanometer sensitivity of the Fourier phase in OCT data to image deformation velocities. The technique was demonstrated by non-invasively showing during de-swelling that osmotic flow through an intact epithelium is negligible and removing the endothelium approximately doubled the initial flow at that interface. The increased functional data further enabled the validation of a mathematical model of the cornea. Included is an efficient method of measuring high temporal resolution (1 minute demonstrated) corneal thickness, using automated collection and semi-automated graph search segmentation. These methods expand OCT capabilities to measure volume change processes for tissues and materials.
    LanguageEnglish
    Pages5579-5593
    JournalBiomedical Optics Express
    Volume8
    Issue number12
    DOIs
    Publication statusPublished - 13 Nov 2017

    Fingerprint

    Optical Coherence Tomography
    Cornea
    Corneal Transplantation
    Endothelium
    Theoretical Models
    Epithelium

    Keywords

    • (110.4500) Optical coherence tomography
    • (120.5050) Phase measurement
    • (170.4500) Optical coherence tomography
    • (170.6935) Tissue characterization

    Cite this

    Lawman, S., Madden, P. W., Romano, V., Dong, Y., Mason, S., Williams, B. M., ... Zheng, Y. (2017). Deformation velocity imaging using optical coherence tomography and its applications to the cornea. Biomedical Optics Express, 8(12), 5579-5593. https://doi.org/10.1364/BOE.8.005579
    Lawman, Samuel ; Madden, Peter W. ; Romano, Vito ; Dong, Yue ; Mason, Sharon ; Williams, Bryan M. ; Kaye, Stephen B. ; Willoughby, Colin ; Harding, Simon P. ; Shen, Yao-Chun ; Zheng, Yalin. / Deformation velocity imaging using optical coherence tomography and its applications to the cornea. In: Biomedical Optics Express. 2017 ; Vol. 8, No. 12. pp. 5579-5593.
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    abstract = "Optical coherence tomography (OCT) can monitor human donor corneas non-invasively during the de-swelling process following storage for corneal transplantation, but currently only resultant thickness as a function of time is extracted. To visualize and quantify the mechanism of de-swelling, we present a method exploiting the nanometer sensitivity of the Fourier phase in OCT data to image deformation velocities. The technique was demonstrated by non-invasively showing during de-swelling that osmotic flow through an intact epithelium is negligible and removing the endothelium approximately doubled the initial flow at that interface. The increased functional data further enabled the validation of a mathematical model of the cornea. Included is an efficient method of measuring high temporal resolution (1 minute demonstrated) corneal thickness, using automated collection and semi-automated graph search segmentation. These methods expand OCT capabilities to measure volume change processes for tissues and materials.",
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    author = "Samuel Lawman and Madden, {Peter W.} and Vito Romano and Yue Dong and Sharon Mason and Williams, {Bryan M.} and Kaye, {Stephen B.} and Colin Willoughby and Harding, {Simon P.} and Yao-Chun Shen and Yalin Zheng",
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    Lawman, S, Madden, PW, Romano, V, Dong, Y, Mason, S, Williams, BM, Kaye, SB, Willoughby, C, Harding, SP, Shen, Y-C & Zheng, Y 2017, 'Deformation velocity imaging using optical coherence tomography and its applications to the cornea', Biomedical Optics Express, vol. 8, no. 12, pp. 5579-5593. https://doi.org/10.1364/BOE.8.005579

    Deformation velocity imaging using optical coherence tomography and its applications to the cornea. / Lawman, Samuel; Madden, Peter W.; Romano, Vito; Dong, Yue; Mason, Sharon; Williams, Bryan M.; Kaye, Stephen B.; Willoughby, Colin; Harding, Simon P.; Shen, Yao-Chun; Zheng, Yalin.

    In: Biomedical Optics Express, Vol. 8, No. 12, 13.11.2017, p. 5579-5593.

    Research output: Contribution to journalArticle

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    AU - Lawman, Samuel

    AU - Madden, Peter W.

    AU - Romano, Vito

    AU - Dong, Yue

    AU - Mason, Sharon

    AU - Williams, Bryan M.

    AU - Kaye, Stephen B.

    AU - Willoughby, Colin

    AU - Harding, Simon P.

    AU - Shen, Yao-Chun

    AU - Zheng, Yalin

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