Abstract
| Language | English |
|---|---|
| Pages | 5579-5593 |
| Journal | Biomedical Optics Express |
| Volume | 8 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 13 Nov 2017 |
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Keywords
- (110.4500) Optical coherence tomography
- (120.5050) Phase measurement
- (170.4500) Optical coherence tomography
- (170.6935) Tissue characterization
Cite this
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Deformation velocity imaging using optical coherence tomography and its applications to the cornea. / Lawman, Samuel; Madden, Peter W.; Romano, Vito; Dong, Yue; Mason, Sharon; Williams, Bryan M.; Kaye, Stephen B.; Willoughby, Colin; Harding, Simon P.; Shen, Yao-Chun; Zheng, Yalin.
In: Biomedical Optics Express, Vol. 8, No. 12, 13.11.2017, p. 5579-5593.Research output: Contribution to journal › Article
TY - JOUR
T1 - Deformation velocity imaging using optical coherence tomography and its applications to the cornea
AU - Lawman, Samuel
AU - Madden, Peter W.
AU - Romano, Vito
AU - Dong, Yue
AU - Mason, Sharon
AU - Williams, Bryan M.
AU - Kaye, Stephen B.
AU - Willoughby, Colin
AU - Harding, Simon P.
AU - Shen, Yao-Chun
AU - Zheng, Yalin
PY - 2017/11/13
Y1 - 2017/11/13
N2 - Optical coherence tomography (OCT) can monitor human donor corneas non-invasively during the de-swelling process following storage for corneal transplantation, but currently only resultant thickness as a function of time is extracted. To visualize and quantify the mechanism of de-swelling, we present a method exploiting the nanometer sensitivity of the Fourier phase in OCT data to image deformation velocities. The technique was demonstrated by non-invasively showing during de-swelling that osmotic flow through an intact epithelium is negligible and removing the endothelium approximately doubled the initial flow at that interface. The increased functional data further enabled the validation of a mathematical model of the cornea. Included is an efficient method of measuring high temporal resolution (1 minute demonstrated) corneal thickness, using automated collection and semi-automated graph search segmentation. These methods expand OCT capabilities to measure volume change processes for tissues and materials.
AB - Optical coherence tomography (OCT) can monitor human donor corneas non-invasively during the de-swelling process following storage for corneal transplantation, but currently only resultant thickness as a function of time is extracted. To visualize and quantify the mechanism of de-swelling, we present a method exploiting the nanometer sensitivity of the Fourier phase in OCT data to image deformation velocities. The technique was demonstrated by non-invasively showing during de-swelling that osmotic flow through an intact epithelium is negligible and removing the endothelium approximately doubled the initial flow at that interface. The increased functional data further enabled the validation of a mathematical model of the cornea. Included is an efficient method of measuring high temporal resolution (1 minute demonstrated) corneal thickness, using automated collection and semi-automated graph search segmentation. These methods expand OCT capabilities to measure volume change processes for tissues and materials.
KW - (110.4500) Optical coherence tomography
KW - (120.5050) Phase measurement
KW - (170.4500) Optical coherence tomography
KW - (170.6935) Tissue characterization
U2 - 10.1364/BOE.8.005579
DO - 10.1364/BOE.8.005579
M3 - Article
VL - 8
SP - 5579
EP - 5593
JO - Biomedical Optics Express
T2 - Biomedical Optics Express
JF - Biomedical Optics Express
SN - 2156-7085
IS - 12
ER -