Daily supplementation of a multiple micronutrient powder improves folate but not thiamine, riboflavin, or vitamin B 12 status among young Laotian children: a randomized controlled trial

Guy-Marino Hinnouho, Daniela Hampel, Setareh Shahab-Ferdows, Maxwell A Barffour, Liadhan McAnena, Charles D Arnold, K Ryan Wessells, Sengchanh Kounnavong, Lindsay H Allen, Helene McNulty, Sonja Y Hess

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Abstract

Purpose: To assess the effects of intervention with a daily multiple micronutrient powder (MNP) on thiamine, riboflavin, folate, and B 12 status among young Laotian children. Methods: Children (n = 1704) aged 6–23 mo, participating in a double-blind placebo-controlled randomized trial were individually randomized to receive daily either MNP (containing 0.5 mg of thiamine, 0.5 mg riboflavin, 150 μg folic acid, and 0.9 μg vitamin B 12 along with 11 other micronutrients) or placebo and followed for ~ 36 weeks. In a randomly selected sub-sample of 260 children, erythrocyte thiamine diphosphate (eThDP), plasma folate and B 12 concentrations, and erythrocyte glutathione reductase activation coefficient (EGRac; riboflavin biomarker) were assessed at baseline and endline. Results: There was no treatment effect on endline eThDP concentrations (110.6 ± 8.9 nmol/L in MNP vs. 109.4 ± 8.9 nmol/L in placebo group; p = 0.924), EGRac (1.46 ± 0.3 vs. 1.49 ± 0.3; p = 0.184) and B 12 concentrations (523.3 ± 24.6 pmol/L vs. 515.9 ± 24.8 pmol/L; p = 0.678). Likewise, the prevalence of thiamine, riboflavin, and B 12 deficiencies did not differ significantly between the two groups. However, endline folate concentration was significantly higher in the MNP compared to the placebo group (28.2 ± 0.8 nmol/L vs 19.9 ± 0.8 nmol/L, respectively; p < 0.001), and correspondingly, the prevalence of folate deficiency was significantly lower in the MNP group (1.6% vs 17.4%; p = 0.015). Conclusions: Compared to a placebo, daily MNP for 9 months increased only folate but not thiamine, riboflavin, or B 12 status in young Laotian children. Trial registration: The trial was registered at www.clinicaltrials.gov (NCT02428647) on April 29 2015.

Original languageEnglish
JournalEuropean Journal of Nutrition
Early online date9 May 2022
DOIs
Publication statusE-pub ahead of print - 9 May 2022

Bibliographical note

Funding Information:
Funding for this research was provided by the Bill & Melinda Gates Foundation (Grant Number OPP1134272), Nutrition International and the Mathile Institute for the Advancement of Human Nutrition (Grant Number 10–1347-UCALIF-07), and the Thrasher Research Fund (award number 14261).

Publisher Copyright:
© 2022, The Author(s).

Keywords

  • Folate
  • Lao PDR
  • MNP
  • Micronutrient powder
  • Riboflavin
  • Thiamine
  • Vitamin B12
  • Young children

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