Current Biological and Pharmacological updates on Wogonin

Sarita Rawat, Gaurav Gupta, Sachchidanand Pathak, Santosh Kumar Singh, Himmat Singh, Anurag Mishra, Ritu Gilhotra, Alaa A. A. Aljabali, Harish Dureja, Murtaza M. Tambuwala, Dinesh K. Chellappan, Kamal Dua

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Abstract

Wogonin (5, 7-Dihydroxy-8-methoxy flavone) is a traditional naturally occurring flavonoid derived from the root extract of Chinese medicine, named Scutellaria baicalensis Georgi. Wogonin contains various biological properties which include allergic diseases, anti-cancer therapy, and anti-inflammatory activities. Wogonin also shows the effects of removing toxins and cleansing the heart (Ancuceanu et al., 2019[1]). The anticancer therapeutic activity of wogonin has been shown by the regulation of different cell signaling pathways, which includes protein kinase B pathway (serine-threonine kinase) and AMP-activated protein kinase pathways (Bei et al., 2020[2]). Wogonin also shows positive therapeutic anticancer effects in breast cancer by inhibiting the 5-LO/BLT2/ERK/IL-8/MMP-9 signaling cascade and establishes a major pharmacological anticancer activity (Bibi et al., 2019[3]). Current biological and pharmacological updates on wogonin have been reviewed (Table 1(Tab. 1); References in Table 1: Du et al., 2019[4]; Ewendt and Foller, 2019[5]; Fang et al., 2019[6]; Gao et al., 2019[7]; Gharari et al., 2020[8]; Hanioka et al., 2020[9]; Hong et al., 2020[10]; Huang et al., 2020[11]; Jiang et al., 2019[12]; Jiao et al., 2019[13]; Khan and Kamal, 2019[14][15]; Khushdil et al., 2019[16]; Kim et al., 2019[17]; Kong et al., 2019[18]; Liang et al., 2019[19]; Liau et al., 2019[20]; Luo et al., 2019[21]; Oomen et al., 2020[22]; Tan et al., 2019[23]; Wang and Cui, 2019[24]; Wang et al., 2019[25][26]; Wang et al., 2020[27]; Xing et al., 2019[28][29]; Zhang et al., 2019[30]).
Original languageEnglish
Pages (from-to)635-640
Number of pages5
JournalEXCLI
Volume19
DOIs
Publication statusPublished - 13 May 2020

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