Cross-Frequency Interactions During Information Flow in Complex Brain Networks Are Facilitated by Scale-Free Properties

Roberto Carlos Sotero, Lazaro Sanchez-Rodriguez, Mehdy Dousty, Yasser Iturria-Medina, Jose Sanchez Bornot

Research output: Contribution to journalArticle

Abstract

We studied the interactions between different temporal scales of the information flow in complex networks and found them to be stronger in scale-free (SF) than in Erdos-Renyi (ER) networks, especially for the case of phase-amplitude coupling (PAC)—the phenomenon where the phase of an oscillatory mode modulates the amplitude of another oscillation. We found that SF networks facilitate PAC between slow and fast frequency components of the information flow, whereas ER networks enable PAC between slow-frequency components. Nodes contributing the most to the generation of PAC in SF networks were non-hubs that connected with high probability to hubs. Additionally, brain networks from healthy controls (HC) and Alzheimer's disease (AD) patients presented a weaker PAC between slow and fast frequencies than SF, but higher than ER. We found that PAC decreased in AD compared to HC and was more strongly correlated to the scores of two different cognitive tests than what the strength of functional connectivity was, suggesting a link between cognitive impairment and multi-scale information flow in the brain.
LanguageEnglish
JournalFrontiers in Physics
DOIs
Publication statusPublished - 30 Jul 2019

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Alzheimer Disease
Brain
Cognitive Dysfunction

Keywords

  • complex networks
  • scale-free networks
  • random networks
  • brain networks
  • random walks
  • cross-frequency interactions
  • Alzheimer's disease
  • information flow

Cite this

Sotero, Roberto Carlos ; Sanchez-Rodriguez, Lazaro ; Dousty, Mehdy ; Iturria-Medina, Yasser ; Sanchez Bornot, Jose. / Cross-Frequency Interactions During Information Flow in Complex Brain Networks Are Facilitated by Scale-Free Properties. In: Frontiers in Physics. 2019.
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abstract = "We studied the interactions between different temporal scales of the information flow in complex networks and found them to be stronger in scale-free (SF) than in Erdos-Renyi (ER) networks, especially for the case of phase-amplitude coupling (PAC)—the phenomenon where the phase of an oscillatory mode modulates the amplitude of another oscillation. We found that SF networks facilitate PAC between slow and fast frequency components of the information flow, whereas ER networks enable PAC between slow-frequency components. Nodes contributing the most to the generation of PAC in SF networks were non-hubs that connected with high probability to hubs. Additionally, brain networks from healthy controls (HC) and Alzheimer's disease (AD) patients presented a weaker PAC between slow and fast frequencies than SF, but higher than ER. We found that PAC decreased in AD compared to HC and was more strongly correlated to the scores of two different cognitive tests than what the strength of functional connectivity was, suggesting a link between cognitive impairment and multi-scale information flow in the brain.",
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Cross-Frequency Interactions During Information Flow in Complex Brain Networks Are Facilitated by Scale-Free Properties. / Sotero, Roberto Carlos; Sanchez-Rodriguez, Lazaro; Dousty, Mehdy; Iturria-Medina, Yasser; Sanchez Bornot, Jose.

In: Frontiers in Physics, 30.07.2019.

Research output: Contribution to journalArticle

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AU - Sanchez Bornot, Jose

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