CPR Guideline Chest Compression Depths May Exceed Requirements for Optimal Physiological Response

Olibhear McAlister, D Guldenring, D Finlay, RR Bond, Hannah Torney, Ben McCartney, Laura Davis, Paul Crawford, Adam Harvey

Research output: Contribution to conferencePaperpeer-review

4 Citations (Scopus)
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The following analyses evaluate the association between chest compression (CC) depth, systolic blood pressure (SBP) and end-tidal carbon dioxide (ETCO2) with their target cut-offs during cardiopulmonary resuscitation (CPR). A twelve-animal porcine study dataset was retrospectively analyzed to assess associations between CC depth, SBP and ETCO2. Manual CCs were applied for 7 two-minute episodes, at CC depths between 10mm-55mm. A rolling 15s analysis window was applied to the continuous signals. Mean peak values were calculated for each window. Correlation analysis was applied to assess strength of association. Optimal CC depth to achieve physiological targets was determined via cut-off analysis. A total of 672 observations for each variable were available for analysis. Pearson correlations (95% confidence interval; p-value) between CC depth and both SBP and ETCO2 were 0.84 (0.82, 0.86; p< 0.001) and 0.75 (0.71, 0.78; p< 0.001) respectively. Optimal CC depth cutoff (sensitivity, specificity) to achieve SBP≥ 100mmHg and ETCO2≥ 10mmHg was 33 mm (98.29%, 88.94%) and 20 mm (95.08%, 78.30%) respectively. A reasonable relationship between CC depth and physiological response was observed. Optimal SBP and ETCO2 cut-offs were achieved significantly below guideline depths. Furthermore, cut-off analysis suggests a disparity between CC depth and physiological targets.
Original languageEnglish
Number of pages4
Publication statusPublished online - 1 Oct 2018
EventComputing in Cardiology - Maastricht, Netherlands
Duration: 23 Sept 201826 Sept 2018


ConferenceComputing in Cardiology
Internet address


  • AED
  • defibrillation efficacy
  • defibrillation
  • CPR
  • Algorithm development


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