CPR Guideline Chest Compression Depths May Exceed Requirements for Optimal Physiological Response

Olibhear McAlister, D Guldenring, D Finlay, RR Bond, Hannah Torney, Ben McCartney, Laura Davis, Paul Crawford, Adam Harvey

Research output: Contribution to conferencePaper

Abstract

The following analyses evaluate the association between chest compression (CC) depth, systolic blood pressure (SBP) and end-tidal carbon dioxide (ETCO2) with their target cut-offs during cardiopulmonary resuscitation (CPR). A twelve-animal porcine study dataset was retrospectively analyzed to assess associations between CC depth, SBP and ETCO2. Manual CCs were applied for 7 two-minute episodes, at CC depths between 10mm-55mm. A rolling 15s analysis window was applied to the continuous signals. Mean peak values were calculated for each window. Correlation analysis was applied to assess strength of association. Optimal CC depth to achieve physiological targets was determined via cut-off analysis. A total of 672 observations for each variable were available for analysis. Pearson correlations (95% confidence interval; p-value) between CC depth and both SBP and ETCO2 were 0.84 (0.82, 0.86; p< 0.001) and 0.75 (0.71, 0.78; p< 0.001) respectively. Optimal CC depth cutoff (sensitivity, specificity) to achieve SBP≥ 100mmHg and ETCO2≥ 10mmHg was 33 mm (98.29%, 88.94%) and 20 mm (95.08%, 78.30%) respectively. A reasonable relationship between CC depth and physiological response was observed. Optimal SBP and ETCO2 cut-offs were achieved significantly below guideline depths. Furthermore, cut-off analysis suggests a disparity between CC depth and physiological targets.
LanguageEnglish
Pages1
Number of pages4
Publication statusE-pub ahead of print - 1 Oct 2018
EventComputing in Cardiology - Maastricht, Netherlands
Duration: 23 Sep 201826 Sep 2018
http://www.cinc.org/2018/CinC2018ProgramOverview.pdf

Conference

ConferenceComputing in Cardiology
CountryNetherlands
CityMaastricht
Period23/09/1826/09/18
Internet address

Fingerprint

Cardiopulmonary Resuscitation
Thorax
Guidelines
Blood Pressure
Carbon Dioxide
Swine
Confidence Intervals
Sensitivity and Specificity

Keywords

  • AED
  • defibrillation efficacy
  • defibrillation
  • CPR
  • Algorithm development

Cite this

McAlister, O., Guldenring, D., Finlay, D., Bond, RR., Torney, H., McCartney, B., ... Harvey, A. (2018). CPR Guideline Chest Compression Depths May Exceed Requirements for Optimal Physiological Response. 1. Paper presented at Computing in Cardiology, Maastricht, Netherlands.
McAlister, Olibhear ; Guldenring, D ; Finlay, D ; Bond, RR ; Torney, Hannah ; McCartney, Ben ; Davis, Laura ; Crawford, Paul ; Harvey, Adam. / CPR Guideline Chest Compression Depths May Exceed Requirements for Optimal Physiological Response. Paper presented at Computing in Cardiology, Maastricht, Netherlands.4 p.
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abstract = "The following analyses evaluate the association between chest compression (CC) depth, systolic blood pressure (SBP) and end-tidal carbon dioxide (ETCO2) with their target cut-offs during cardiopulmonary resuscitation (CPR). A twelve-animal porcine study dataset was retrospectively analyzed to assess associations between CC depth, SBP and ETCO2. Manual CCs were applied for 7 two-minute episodes, at CC depths between 10mm-55mm. A rolling 15s analysis window was applied to the continuous signals. Mean peak values were calculated for each window. Correlation analysis was applied to assess strength of association. Optimal CC depth to achieve physiological targets was determined via cut-off analysis. A total of 672 observations for each variable were available for analysis. Pearson correlations (95{\%} confidence interval; p-value) between CC depth and both SBP and ETCO2 were 0.84 (0.82, 0.86; p< 0.001) and 0.75 (0.71, 0.78; p< 0.001) respectively. Optimal CC depth cutoff (sensitivity, specificity) to achieve SBP≥ 100mmHg and ETCO2≥ 10mmHg was 33 mm (98.29{\%}, 88.94{\%}) and 20 mm (95.08{\%}, 78.30{\%}) respectively. A reasonable relationship between CC depth and physiological response was observed. Optimal SBP and ETCO2 cut-offs were achieved significantly below guideline depths. Furthermore, cut-off analysis suggests a disparity between CC depth and physiological targets.",
keywords = "AED, defibrillation efficacy, defibrillation, CPR, Algorithm development",
author = "Olibhear McAlister and D Guldenring and D Finlay and RR Bond and Hannah Torney and Ben McCartney and Laura Davis and Paul Crawford and Adam Harvey",
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McAlister, O, Guldenring, D, Finlay, D, Bond, RR, Torney, H, McCartney, B, Davis, L, Crawford, P & Harvey, A 2018, 'CPR Guideline Chest Compression Depths May Exceed Requirements for Optimal Physiological Response' Paper presented at Computing in Cardiology, Maastricht, Netherlands, 23/09/18 - 26/09/18, pp. 1.

CPR Guideline Chest Compression Depths May Exceed Requirements for Optimal Physiological Response. / McAlister, Olibhear; Guldenring, D; Finlay, D; Bond, RR; Torney, Hannah; McCartney, Ben; Davis, Laura; Crawford, Paul; Harvey, Adam.

2018. 1 Paper presented at Computing in Cardiology, Maastricht, Netherlands.

Research output: Contribution to conferencePaper

TY - CONF

T1 - CPR Guideline Chest Compression Depths May Exceed Requirements for Optimal Physiological Response

AU - McAlister, Olibhear

AU - Guldenring, D

AU - Finlay, D

AU - Bond, RR

AU - Torney, Hannah

AU - McCartney, Ben

AU - Davis, Laura

AU - Crawford, Paul

AU - Harvey, Adam

PY - 2018/10/1

Y1 - 2018/10/1

N2 - The following analyses evaluate the association between chest compression (CC) depth, systolic blood pressure (SBP) and end-tidal carbon dioxide (ETCO2) with their target cut-offs during cardiopulmonary resuscitation (CPR). A twelve-animal porcine study dataset was retrospectively analyzed to assess associations between CC depth, SBP and ETCO2. Manual CCs were applied for 7 two-minute episodes, at CC depths between 10mm-55mm. A rolling 15s analysis window was applied to the continuous signals. Mean peak values were calculated for each window. Correlation analysis was applied to assess strength of association. Optimal CC depth to achieve physiological targets was determined via cut-off analysis. A total of 672 observations for each variable were available for analysis. Pearson correlations (95% confidence interval; p-value) between CC depth and both SBP and ETCO2 were 0.84 (0.82, 0.86; p< 0.001) and 0.75 (0.71, 0.78; p< 0.001) respectively. Optimal CC depth cutoff (sensitivity, specificity) to achieve SBP≥ 100mmHg and ETCO2≥ 10mmHg was 33 mm (98.29%, 88.94%) and 20 mm (95.08%, 78.30%) respectively. A reasonable relationship between CC depth and physiological response was observed. Optimal SBP and ETCO2 cut-offs were achieved significantly below guideline depths. Furthermore, cut-off analysis suggests a disparity between CC depth and physiological targets.

AB - The following analyses evaluate the association between chest compression (CC) depth, systolic blood pressure (SBP) and end-tidal carbon dioxide (ETCO2) with their target cut-offs during cardiopulmonary resuscitation (CPR). A twelve-animal porcine study dataset was retrospectively analyzed to assess associations between CC depth, SBP and ETCO2. Manual CCs were applied for 7 two-minute episodes, at CC depths between 10mm-55mm. A rolling 15s analysis window was applied to the continuous signals. Mean peak values were calculated for each window. Correlation analysis was applied to assess strength of association. Optimal CC depth to achieve physiological targets was determined via cut-off analysis. A total of 672 observations for each variable were available for analysis. Pearson correlations (95% confidence interval; p-value) between CC depth and both SBP and ETCO2 were 0.84 (0.82, 0.86; p< 0.001) and 0.75 (0.71, 0.78; p< 0.001) respectively. Optimal CC depth cutoff (sensitivity, specificity) to achieve SBP≥ 100mmHg and ETCO2≥ 10mmHg was 33 mm (98.29%, 88.94%) and 20 mm (95.08%, 78.30%) respectively. A reasonable relationship between CC depth and physiological response was observed. Optimal SBP and ETCO2 cut-offs were achieved significantly below guideline depths. Furthermore, cut-off analysis suggests a disparity between CC depth and physiological targets.

KW - AED

KW - defibrillation efficacy

KW - defibrillation

KW - CPR

KW - Algorithm development

UR - http://www.cinc2018.org/

M3 - Paper

SP - 1

ER -

McAlister O, Guldenring D, Finlay D, Bond RR, Torney H, McCartney B et al. CPR Guideline Chest Compression Depths May Exceed Requirements for Optimal Physiological Response. 2018. Paper presented at Computing in Cardiology, Maastricht, Netherlands.