COVID-19 pandemic: an overview of epidemiology, pathogenesis, diagnostics and potential vaccines and therapeutics

Haneen Amawi, Ghina'a I Abu Deiab, Alaa A A Aljabali, Kamal Dua, Murtaza M Tambuwala

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

At the time of writing this review, severe acute respiratory coronavirus syndrome-2 (SARS-CoV-2) has in- fected more than 2,355,853 patients and resulted in more than 164,656 deaths worldwide (as of 20 April 2020). This review highlights the preventive measures, available clinical therapies and the potential of vaccine development against SARS-CoV-2 by taking into consideration the strong genetic similarities of the 2003 epidemic SARS-CoV. Recent studies are investigating the repurposing of US FDA-approved drugs as there is no available vaccine yet with many attempts under clinical evaluation. Several antivirals, anti- malarials and immunomodulators that have shown activity against SARS-CoV and Middle East coronavirus respiratory syndromes are being evaluated. In particular, hydroxychloroquine, remdesivir, favipiravir, ar- bidol, tocilizumab and bevacizumab have shown promising results. The main aim of this review is to provide an overview of this pandemic and where we currently stand.
Original languageEnglish
Pages (from-to)245-268
Number of pages24
JournalTherapeutic Delivery
Volume11
Issue number4
Early online date12 May 2020
DOIs
Publication statusE-pub ahead of print - 12 May 2020

Keywords

  • COVID-19
  • SARS-CoV-2
  • infection
  • repurposed therapies
  • vaccine
  • viruses

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