TY - JOUR
T1 - Corneal Angiography for Guiding and Evaluating Fine-Needle Diathermy Treatment of Corneal Neovascularization
AU - Spiteri, Natasha
AU - Romano, Vito
AU - Zheng, Yalin
AU - Yadav, Sohraab
AU - Dwivedi, Rahul
AU - Chen, Jern
AU - Ahmad, Sajjad
AU - Willoughby, Colin
AU - Kaye, Stephen B.
PY - 2015/2/5
Y1 - 2015/2/5
N2 - PURPOSE:To investigate the outcome of selective occlusion of the afferent vessel of corneal neovascular complexes (CoNVs), using angiographically guided fine-needle diathermy (FND).DESIGN:Retrospective interventional case series.SUBJECTS:Patients with CoNV unresponsive to topical steroid therapy.METHODS:Visual acuity, color images, and fluorescein angiography and indocyanine green angiography were measured before and after FND with a minimum of 3 months of follow-up. The number of afferent vessels crossing the limbus, time to fluorescein leakage, area, and geometric properties of the CoNV were determined using an in-house automated program written in numerical computing language (MatLab R14; The MathWorks Inc., Natick, MA). The location of the afferent vessel was identified from the angiographic images and marked at the slit lamp using a needle to make a cut to the depth of the vessel. We then applied FND using an electrolysis needle.MAIN OUTCOME MEASURES:Area of CoNV.RESULTS:Thirty patients underwent FND for CoNV that had not responded to treatment with topical steroids. The CoNV was associated with previous microbial keratitis (n = 26), intrastromal corneal ring segments (n = 2), ectodermal dysplasia (n = 1), and corneal choristoma (n = 1). Duration of CoNV was >6 months in 23 patients (77%), between 3 and 6 months in 3 patients (10%), and
AB - PURPOSE:To investigate the outcome of selective occlusion of the afferent vessel of corneal neovascular complexes (CoNVs), using angiographically guided fine-needle diathermy (FND).DESIGN:Retrospective interventional case series.SUBJECTS:Patients with CoNV unresponsive to topical steroid therapy.METHODS:Visual acuity, color images, and fluorescein angiography and indocyanine green angiography were measured before and after FND with a minimum of 3 months of follow-up. The number of afferent vessels crossing the limbus, time to fluorescein leakage, area, and geometric properties of the CoNV were determined using an in-house automated program written in numerical computing language (MatLab R14; The MathWorks Inc., Natick, MA). The location of the afferent vessel was identified from the angiographic images and marked at the slit lamp using a needle to make a cut to the depth of the vessel. We then applied FND using an electrolysis needle.MAIN OUTCOME MEASURES:Area of CoNV.RESULTS:Thirty patients underwent FND for CoNV that had not responded to treatment with topical steroids. The CoNV was associated with previous microbial keratitis (n = 26), intrastromal corneal ring segments (n = 2), ectodermal dysplasia (n = 1), and corneal choristoma (n = 1). Duration of CoNV was >6 months in 23 patients (77%), between 3 and 6 months in 3 patients (10%), and
KW - corneal angiography
KW - corneal neovascularization
KW - fine needle diathermy
UR - https://pure.ulster.ac.uk/en/publications/corneal-angiography-for-guiding-and-evaluating-fine-needle-diathe
U2 - 10.1016/j.ophtha.2015.02.012
DO - 10.1016/j.ophtha.2015.02.012
M3 - Article
SN - 1549-4713
VL - 122
SP - 1079
EP - 1084
JO - Ophthalmology: Journal of the American Academy of Ophthalmology
JF - Ophthalmology: Journal of the American Academy of Ophthalmology
IS - 6
ER -