Corneal Angiography for Guiding and Evaluating Fine-Needle Diathermy Treatment of Corneal Neovascularization

Natasha Spiteri, Vito Romano, Yalin Zheng, Sohraab Yadav, Rahul Dwivedi, Jern Chen, Sajjad Ahmad, Colin Willoughby, Stephen B. Kaye

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    56 Citations (Scopus)


    PURPOSE:To investigate the outcome of selective occlusion of the afferent vessel of corneal neovascular complexes (CoNVs), using angiographically guided fine-needle diathermy (FND).DESIGN:Retrospective interventional case series.SUBJECTS:Patients with CoNV unresponsive to topical steroid therapy.METHODS:Visual acuity, color images, and fluorescein angiography and indocyanine green angiography were measured before and after FND with a minimum of 3 months of follow-up. The number of afferent vessels crossing the limbus, time to fluorescein leakage, area, and geometric properties of the CoNV were determined using an in-house automated program written in numerical computing language (MatLab R14; The MathWorks Inc., Natick, MA). The location of the afferent vessel was identified from the angiographic images and marked at the slit lamp using a needle to make a cut to the depth of the vessel. We then applied FND using an electrolysis needle.MAIN OUTCOME MEASURES:Area of CoNV.RESULTS:Thirty patients underwent FND for CoNV that had not responded to treatment with topical steroids. The CoNV was associated with previous microbial keratitis (n = 26), intrastromal corneal ring segments (n = 2), ectodermal dysplasia (n = 1), and corneal choristoma (n = 1). Duration of CoNV was >6 months in 23 patients (77%), between 3 and 6 months in 3 patients (10%), and
    Original languageEnglish
    Pages (from-to)1079-1084
    JournalOphthalmology: Journal of the American Academy of Ophthalmology
    Issue number6
    Publication statusAccepted/In press - 5 Feb 2015


    • corneal angiography
    • corneal neovascularization
    • fine needle diathermy


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