Corneal Angiography for Guiding and Evaluating Fine-Needle Diathermy Treatment of Corneal Neovascularization

Natasha Spiteri, Vito Romano, Yalin Zheng, Sohraab Yadav, Rahul Dwivedi, Jern Chen, Sajjad Ahmad, Colin Willoughby, Stephen B. Kaye

    Research output: Contribution to journalArticle

    25 Citations (Scopus)

    Abstract

    PURPOSE:To investigate the outcome of selective occlusion of the afferent vessel of corneal neovascular complexes (CoNVs), using angiographically guided fine-needle diathermy (FND).DESIGN:Retrospective interventional case series.SUBJECTS:Patients with CoNV unresponsive to topical steroid therapy.METHODS:Visual acuity, color images, and fluorescein angiography and indocyanine green angiography were measured before and after FND with a minimum of 3 months of follow-up. The number of afferent vessels crossing the limbus, time to fluorescein leakage, area, and geometric properties of the CoNV were determined using an in-house automated program written in numerical computing language (MatLab R14; The MathWorks Inc., Natick, MA). The location of the afferent vessel was identified from the angiographic images and marked at the slit lamp using a needle to make a cut to the depth of the vessel. We then applied FND using an electrolysis needle.MAIN OUTCOME MEASURES:Area of CoNV.RESULTS:Thirty patients underwent FND for CoNV that had not responded to treatment with topical steroids. The CoNV was associated with previous microbial keratitis (n = 26), intrastromal corneal ring segments (n = 2), ectodermal dysplasia (n = 1), and corneal choristoma (n = 1). Duration of CoNV was >6 months in 23 patients (77%), between 3 and 6 months in 3 patients (10%), and
    LanguageEnglish
    Pages1079-1084
    JournalOphthalmology: Journal of the American Academy of Ophthalmology
    Volume122
    Issue number6
    DOIs
    Publication statusAccepted/In press - 5 Feb 2015

    Fingerprint

    Corneal Neovascularization
    Diathermy
    Needles
    Angiography
    Therapeutics
    Anhidrotic Ectodermal Dysplasia 1
    Steroids
    Electrolysis
    Choristoma
    Indocyanine Green
    Keratitis
    Fluorescein Angiography
    Fluorescein
    Visual Acuity
    Language
    Color

    Keywords

    • corneal angiography
    • corneal neovascularization
    • fine needle diathermy

    Cite this

    Spiteri, Natasha ; Romano, Vito ; Zheng, Yalin ; Yadav, Sohraab ; Dwivedi, Rahul ; Chen, Jern ; Ahmad, Sajjad ; Willoughby, Colin ; Kaye, Stephen B. / Corneal Angiography for Guiding and Evaluating Fine-Needle Diathermy Treatment of Corneal Neovascularization. In: Ophthalmology: Journal of the American Academy of Ophthalmology. 2015 ; Vol. 122, No. 6. pp. 1079-1084.
    @article{71728e6919884798a797f9b4e43beeff,
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    abstract = "PURPOSE:To investigate the outcome of selective occlusion of the afferent vessel of corneal neovascular complexes (CoNVs), using angiographically guided fine-needle diathermy (FND).DESIGN:Retrospective interventional case series.SUBJECTS:Patients with CoNV unresponsive to topical steroid therapy.METHODS:Visual acuity, color images, and fluorescein angiography and indocyanine green angiography were measured before and after FND with a minimum of 3 months of follow-up. The number of afferent vessels crossing the limbus, time to fluorescein leakage, area, and geometric properties of the CoNV were determined using an in-house automated program written in numerical computing language (MatLab R14; The MathWorks Inc., Natick, MA). The location of the afferent vessel was identified from the angiographic images and marked at the slit lamp using a needle to make a cut to the depth of the vessel. We then applied FND using an electrolysis needle.MAIN OUTCOME MEASURES:Area of CoNV.RESULTS:Thirty patients underwent FND for CoNV that had not responded to treatment with topical steroids. The CoNV was associated with previous microbial keratitis (n = 26), intrastromal corneal ring segments (n = 2), ectodermal dysplasia (n = 1), and corneal choristoma (n = 1). Duration of CoNV was >6 months in 23 patients (77{\%}), between 3 and 6 months in 3 patients (10{\%}), and",
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    author = "Natasha Spiteri and Vito Romano and Yalin Zheng and Sohraab Yadav and Rahul Dwivedi and Jern Chen and Sajjad Ahmad and Colin Willoughby and Kaye, {Stephen B.}",
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    Corneal Angiography for Guiding and Evaluating Fine-Needle Diathermy Treatment of Corneal Neovascularization. / Spiteri, Natasha; Romano, Vito; Zheng, Yalin; Yadav, Sohraab; Dwivedi, Rahul; Chen, Jern; Ahmad, Sajjad; Willoughby, Colin; Kaye, Stephen B.

    In: Ophthalmology: Journal of the American Academy of Ophthalmology, Vol. 122, No. 6, 05.02.2015, p. 1079-1084.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Corneal Angiography for Guiding and Evaluating Fine-Needle Diathermy Treatment of Corneal Neovascularization

    AU - Spiteri, Natasha

    AU - Romano, Vito

    AU - Zheng, Yalin

    AU - Yadav, Sohraab

    AU - Dwivedi, Rahul

    AU - Chen, Jern

    AU - Ahmad, Sajjad

    AU - Willoughby, Colin

    AU - Kaye, Stephen B.

    PY - 2015/2/5

    Y1 - 2015/2/5

    N2 - PURPOSE:To investigate the outcome of selective occlusion of the afferent vessel of corneal neovascular complexes (CoNVs), using angiographically guided fine-needle diathermy (FND).DESIGN:Retrospective interventional case series.SUBJECTS:Patients with CoNV unresponsive to topical steroid therapy.METHODS:Visual acuity, color images, and fluorescein angiography and indocyanine green angiography were measured before and after FND with a minimum of 3 months of follow-up. The number of afferent vessels crossing the limbus, time to fluorescein leakage, area, and geometric properties of the CoNV were determined using an in-house automated program written in numerical computing language (MatLab R14; The MathWorks Inc., Natick, MA). The location of the afferent vessel was identified from the angiographic images and marked at the slit lamp using a needle to make a cut to the depth of the vessel. We then applied FND using an electrolysis needle.MAIN OUTCOME MEASURES:Area of CoNV.RESULTS:Thirty patients underwent FND for CoNV that had not responded to treatment with topical steroids. The CoNV was associated with previous microbial keratitis (n = 26), intrastromal corneal ring segments (n = 2), ectodermal dysplasia (n = 1), and corneal choristoma (n = 1). Duration of CoNV was >6 months in 23 patients (77%), between 3 and 6 months in 3 patients (10%), and

    AB - PURPOSE:To investigate the outcome of selective occlusion of the afferent vessel of corneal neovascular complexes (CoNVs), using angiographically guided fine-needle diathermy (FND).DESIGN:Retrospective interventional case series.SUBJECTS:Patients with CoNV unresponsive to topical steroid therapy.METHODS:Visual acuity, color images, and fluorescein angiography and indocyanine green angiography were measured before and after FND with a minimum of 3 months of follow-up. The number of afferent vessels crossing the limbus, time to fluorescein leakage, area, and geometric properties of the CoNV were determined using an in-house automated program written in numerical computing language (MatLab R14; The MathWorks Inc., Natick, MA). The location of the afferent vessel was identified from the angiographic images and marked at the slit lamp using a needle to make a cut to the depth of the vessel. We then applied FND using an electrolysis needle.MAIN OUTCOME MEASURES:Area of CoNV.RESULTS:Thirty patients underwent FND for CoNV that had not responded to treatment with topical steroids. The CoNV was associated with previous microbial keratitis (n = 26), intrastromal corneal ring segments (n = 2), ectodermal dysplasia (n = 1), and corneal choristoma (n = 1). Duration of CoNV was >6 months in 23 patients (77%), between 3 and 6 months in 3 patients (10%), and

    KW - corneal angiography

    KW - corneal neovascularization

    KW - fine needle diathermy

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    DO - 10.1016/j.ophtha.2015.02.012

    M3 - Article

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    EP - 1084

    JO - Ophthalmology: Journal of the American Academy of Ophthalmology

    T2 - Ophthalmology: Journal of the American Academy of Ophthalmology

    JF - Ophthalmology: Journal of the American Academy of Ophthalmology

    SN - 0161-6420

    IS - 6

    ER -