CONTROLLING THE SIZE AND SIZE DISTRIBUTION OF GOLD NANOPARTICLES: A DESIGN OF EXPERIMENT STUDY

D Kumar, BJ Meenan, I Mutreja, RA D'Sa, D Dixon

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The Turkevich method is the oldest and most widely employed protocol for the production of colloidal gold. Gold nanoparticles are nontoxic in nature and have potential applications in various biomedical fields including drug delivery and bioimaging. These metallic nanoparticles can be functionalized with drugs, targeting ligands such as tumor necrosis factor and groups (e.g., Poly ethylene glycol) to provide shielding from undesired immune responses. In this study we investigate the influence of process variables on the synthesis of nanoparticles by the reduction of chloroauric acid (HAuCl4) solution with sodium citrate. A design of experiment (DoE) approach was used to investigate the influence of production volume, temperature, stirring rate and sodium citrate concentration on the physical properties of the nanoparticles namely size, size distribution, zeta potential and UV-Vis characteristics. The study showed that the relative amount of sodium citrate added (Au/citrate mole ratio) had a significant effect on the size, poly dispersity index (PDI), the number of peaks in the size distribution and the position of Lambda max in the UV-Vis spectra. By varying the Au/Citrate ratio it is possible to synthesize particles with average diameters from 20 to 80 nm. However, the use of low amounts of sodium citrate in order to produce particles larger than ~35 nm tends to result in a wide bimodal size distribution.
LanguageEnglish
Pages1250023
JournalInternational Journal of Nanoscience
Volume11
Issue number2
DOIs
Publication statusPublished - Apr 2012

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Gold
Design of experiments
Nanoparticles
Citric Acid
Gold Colloid
Zeta potential
Drug delivery
Shielding
Polyethylene glycols
Tumor Necrosis Factor-alpha
Physical properties
Ligands
sodium citrate
Temperature
acid gold tetrachloride

Cite this

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CONTROLLING THE SIZE AND SIZE DISTRIBUTION OF GOLD NANOPARTICLES: A DESIGN OF EXPERIMENT STUDY. / Kumar, D; Meenan, BJ; Mutreja, I; D'Sa, RA; Dixon, D.

In: International Journal of Nanoscience, Vol. 11, No. 2, 04.2012, p. 1250023.

Research output: Contribution to journalArticle

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