Controlled engineering of highly aligned fibrous dosage form matrices for controlled release

Shuting Wu, Zeeshan Ahmad, Jing Song Li, Ming Wei Chang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In this study, complex drug-cellulose acetate (CA) composite films were designed and fabricated possessing pre-determined grid spacing for inter-connected fibrous films. Ibuprofen (IBU) was selected as the active ingredient and grid spacing was varied between 300 and 500 μm (fiber diameter ∼ 35 μm) for various geometries. Process parameter impact on fiber morphology and deposition was investigated. FTIR confirmed IBU encapsulation and XRD analysis indicated the drug was dispersed (amorphous) in films. Inter-connected grid void geometry was shown to impact water contact behavior, and drug release mechanism was shown to be Fickian diffusion. Furthermore, drug release rate depended on geometry of engineered structures. The findings suggest a spatial design approach for modulated drug release from bespoke drug delivery dosage forms.

Original languageEnglish
Pages (from-to)134-137
Number of pages4
JournalMaterials Letters
Volume232
Early online date20 Aug 2018
DOIs
Publication statusPublished - 1 Dec 2018

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Keywords

  • Biomaterials
  • Controlled release
  • Electrohydrodynamic printing
  • Microstructure
  • Patterning

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