Control of Klebsiella pneumoniae Infection in Mice by Using Dissolving Microarray Patches Containing Gentamicin

Aoife M. Rodgers; Maeliosa T. C. McCrudden; Aaron J. Courtenay; Mary-Carmel Kearney; Katherine L. Edwards; Rebecca J. Ingram; Jose Bengoechea; Ryan F. Donnelly

doi:10.1128/AAC.02612-18

Control of Klebsiella pneumoniae Infection in Mice by Using Dissolving Microarray Patches Containing Gentamicin

Aoife M. Rodgers, Maeliosa T. C. McCrudden, Aaron J. Courtenay, Mary-Carmel Kearney, Katherine L. Edwards, Rebecca J. Ingram, Jose Bengoechea, Ryan F. Donnelly

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Abstract

Using a murine model of Klebsiella pneumoniae bacterial infection, we
demonstrate that gentamicin dissolving microarray patches, applied to murine ears, could control K. pneumoniae infection. Mice treated with microarray patches had reduced bacterial burden in the nasal-associated lymphoid tissue and lungs compared with their untreated counterparts. This proof of concept study represents the first published data on the in vivo delivery of the antibiotic gentamicin via dissolving microarray patches, resulting in the control of bacterial infection.

Original language	English
Article number	e02612-18
Number of pages	5
Journal	Antimicrobial Agents and Chemotherapy
Volume	63
Issue number	5
Early online date	25 Apr 2019
DOIs	https://doi.org/10.1128/AAC.02612-18
Publication status	Published (in print/issue) - 31 May 2019

Keywords

Klebsiella pneumoniae
gentamicin
microarray
transdermal delivery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.02612-18

Final Published PDFFinal published version, 590 KBLicence: CC BY

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Rodgers, A. M., McCrudden, M. T. C., Courtenay, A. J., Kearney, M-C., Edwards, K. L., Ingram, R. J., Bengoechea, J., & Donnelly, R. F. (2019). Control of Klebsiella pneumoniae Infection in Mice by Using Dissolving Microarray Patches Containing Gentamicin. Antimicrobial Agents and Chemotherapy, 63(5), Article e02612-18. Advance online publication. https://doi.org/10.1128/AAC.02612-18

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abstract = "Using a murine model of Klebsiella pneumoniae bacterial infection, wedemonstrate that gentamicin dissolving microarray patches, applied to murine ears, could control K. pneumoniae infection. Mice treated with microarray patches had reduced bacterial burden in the nasal-associated lymphoid tissue and lungs compared with their untreated counterparts. This proof of concept study represents the first published data on the in vivo delivery of the antibiotic gentamicin via dissolving microarray patches, resulting in the control of bacterial infection.",

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AU - Courtenay, Aaron J.

AU - Kearney, Mary-Carmel

AU - Edwards, Katherine L.

AU - Ingram, Rebecca J.

AU - Bengoechea, Jose

AU - Donnelly, Ryan F.

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AB - Using a murine model of Klebsiella pneumoniae bacterial infection, wedemonstrate that gentamicin dissolving microarray patches, applied to murine ears, could control K. pneumoniae infection. Mice treated with microarray patches had reduced bacterial burden in the nasal-associated lymphoid tissue and lungs compared with their untreated counterparts. This proof of concept study represents the first published data on the in vivo delivery of the antibiotic gentamicin via dissolving microarray patches, resulting in the control of bacterial infection.

KW - Klebsiella pneumoniae

KW - gentamicin

KW - microarray

KW - transdermal delivery

UR - https://pure.ulster.ac.uk/en/publications/control-of-klebsiella-pneumoniae-infection-in-mice-by-using-disso

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ER -

Control of Klebsiella pneumoniae Infection in Mice by Using Dissolving Microarray Patches Containing Gentamicin

Abstract

Keywords

UN SDGs

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