Control of Klebsiella pneumoniae Infection in Mice by Using Dissolving Microarray Patches Containing Gentamicin

Aoife M. Rodgers, Maeliosa T. C. McCrudden, Aaron J. Courtenay, Mary-Carmel Kearney, Katherine L. Edwards, Rebecca J. Ingram, Jose Bengoechea, Ryan F. Donnelly

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Abstract

Using a murine model of Klebsiella pneumoniae bacterial infection, we
demonstrate that gentamicin dissolving microarray patches, applied to murine ears, could control K. pneumoniae infection. Mice treated with microarray patches had reduced bacterial burden in the nasal-associated lymphoid tissue and lungs compared with their untreated counterparts. This proof of concept study represents the first published data on the in vivo delivery of the antibiotic gentamicin via dissolving microarray patches, resulting in the control of bacterial infection.
Original languageEnglish
Article numbere02612-18
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume63
Issue number5
Early online date25 Apr 2019
DOIs
Publication statusPublished - 31 May 2019

Keywords

  • Klebsiella pneumoniae
  • gentamicin
  • microarray
  • transdermal delivery

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Aaron Courtenay

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Cite this

Rodgers, A. M., McCrudden, M. T. C., Courtenay, A. J., Kearney, M-C., Edwards, K. L., Ingram, R. J., Bengoechea, J., & Donnelly, R. F. (2019). Control of Klebsiella pneumoniae Infection in Mice by Using Dissolving Microarray Patches Containing Gentamicin. Antimicrobial Agents and Chemotherapy, 63(5), [e02612-18]. https://doi.org/10.1128/AAC.02612-18