Consumption of a soy drink has no effect on cognitive function but may alleviate vasomotor symptoms in post-menopausal women; a randomised trial

Orlaith Furlong, Heather Parr, Stephanie Hodge, Mary Slevin, Liz Simpson, Emeir M. McSorley, Jacqueline McCormack, Pamela Magee

Research output: Contribution to journalArticle

Abstract

Purpose: Cognitive decline is commonly reported during the menopausal transition, with memory and attention being particularly affected. The aim of this study was to investigate the effects of a commercially available soy drink on cognitive function and menopausal symptoms in post-menopausal women.
Methods: 101 post-menopausal women, aged 44–63years, were randomly assigned to consume a volume of soy drink providing a low (10mg/day; control group), medium (35mg/day), or high (60mg/day) dose of isoflavones for 12weeks. Cognitive function (spatial working memory, spatial span, pattern recognition memory, 5-choice reaction time, and match to sample visual search) was assessed using CANTAB pre- and post-the 12week intervention. Menopausal symptoms were assessed using Greene’s Climacteric Scale.
Results: No significant differences were observed between the groups for any of the cognitive function outcomes measured. Soy drink consumption had no effect on menopausal symptoms overall; however, when women were stratified according to the severity of vasomotor symptoms (VMS) at baseline, women with more severe symptoms at baseline in the medium group had a significant reduction (P = 0.001) in VMS post-intervention (mean change from baseline score: − 2.15 ± 1.73) in comparison to those with less severe VMS (mean change from baseline score: 0.06 ± 1.21).
Conclusions: Soy drink consumption had no effect on cognitive function in post-menopausal women. Consumption of ~ 350ml/day (35mg IFs) for 12weeks significantly reduced VMS in those with more severe symptoms at baseline. This finding is clinically relevant as soy drinks may provide an alternative, natural, treatment for alleviating VMS, highly prevalent among western women
LanguageEnglish
Number of pages12
JournalEuropean Journal of Nutrition
Early online date12 Mar 2019
DOIs
Publication statusE-pub ahead of print - 12 Mar 2019

Fingerprint

Cognition
Isoflavones
Short-Term Memory
Reaction Time
Control Groups

Keywords

  • CANTAB
  • Equol
  • Hot flash
  • Hot flush
  • Isoflavones
  • Menopausal symptoms

Cite this

@article{1f9373f797c84dc19e2652bddd02a947,
title = "Consumption of a soy drink has no effect on cognitive function but may alleviate vasomotor symptoms in post-menopausal women; a randomised trial",
abstract = "Purpose: Cognitive decline is commonly reported during the menopausal transition, with memory and attention being particularly affected. The aim of this study was to investigate the effects of a commercially available soy drink on cognitive function and menopausal symptoms in post-menopausal women.Methods: 101 post-menopausal women, aged 44–63years, were randomly assigned to consume a volume of soy drink providing a low (10mg/day; control group), medium (35mg/day), or high (60mg/day) dose of isoflavones for 12weeks. Cognitive function (spatial working memory, spatial span, pattern recognition memory, 5-choice reaction time, and match to sample visual search) was assessed using CANTAB pre- and post-the 12week intervention. Menopausal symptoms were assessed using Greene’s Climacteric Scale.Results: No significant differences were observed between the groups for any of the cognitive function outcomes measured. Soy drink consumption had no effect on menopausal symptoms overall; however, when women were stratified according to the severity of vasomotor symptoms (VMS) at baseline, women with more severe symptoms at baseline in the medium group had a significant reduction (P = 0.001) in VMS post-intervention (mean change from baseline score: − 2.15 ± 1.73) in comparison to those with less severe VMS (mean change from baseline score: 0.06 ± 1.21).Conclusions: Soy drink consumption had no effect on cognitive function in post-menopausal women. Consumption of ~ 350ml/day (35mg IFs) for 12weeks significantly reduced VMS in those with more severe symptoms at baseline. This finding is clinically relevant as soy drinks may provide an alternative, natural, treatment for alleviating VMS, highly prevalent among western women",
keywords = "CANTAB, Equol, Hot flash, Hot flush, Isoflavones, Menopausal symptoms",
author = "Orlaith Furlong and Heather Parr and Stephanie Hodge and Mary Slevin and Liz Simpson and McSorley, {Emeir M.} and Jacqueline McCormack and Pamela Magee",
year = "2019",
month = "3",
day = "12",
doi = "10.1007/s00394-019-01942-5",
language = "English",
journal = "European Journal of Nutrition",
issn = "1436-6207",

}

TY - JOUR

T1 - Consumption of a soy drink has no effect on cognitive function but may alleviate vasomotor symptoms in post-menopausal women; a randomised trial

AU - Furlong, Orlaith

AU - Parr, Heather

AU - Hodge, Stephanie

AU - Slevin, Mary

AU - Simpson, Liz

AU - McSorley, Emeir M.

AU - McCormack, Jacqueline

AU - Magee, Pamela

PY - 2019/3/12

Y1 - 2019/3/12

N2 - Purpose: Cognitive decline is commonly reported during the menopausal transition, with memory and attention being particularly affected. The aim of this study was to investigate the effects of a commercially available soy drink on cognitive function and menopausal symptoms in post-menopausal women.Methods: 101 post-menopausal women, aged 44–63years, were randomly assigned to consume a volume of soy drink providing a low (10mg/day; control group), medium (35mg/day), or high (60mg/day) dose of isoflavones for 12weeks. Cognitive function (spatial working memory, spatial span, pattern recognition memory, 5-choice reaction time, and match to sample visual search) was assessed using CANTAB pre- and post-the 12week intervention. Menopausal symptoms were assessed using Greene’s Climacteric Scale.Results: No significant differences were observed between the groups for any of the cognitive function outcomes measured. Soy drink consumption had no effect on menopausal symptoms overall; however, when women were stratified according to the severity of vasomotor symptoms (VMS) at baseline, women with more severe symptoms at baseline in the medium group had a significant reduction (P = 0.001) in VMS post-intervention (mean change from baseline score: − 2.15 ± 1.73) in comparison to those with less severe VMS (mean change from baseline score: 0.06 ± 1.21).Conclusions: Soy drink consumption had no effect on cognitive function in post-menopausal women. Consumption of ~ 350ml/day (35mg IFs) for 12weeks significantly reduced VMS in those with more severe symptoms at baseline. This finding is clinically relevant as soy drinks may provide an alternative, natural, treatment for alleviating VMS, highly prevalent among western women

AB - Purpose: Cognitive decline is commonly reported during the menopausal transition, with memory and attention being particularly affected. The aim of this study was to investigate the effects of a commercially available soy drink on cognitive function and menopausal symptoms in post-menopausal women.Methods: 101 post-menopausal women, aged 44–63years, were randomly assigned to consume a volume of soy drink providing a low (10mg/day; control group), medium (35mg/day), or high (60mg/day) dose of isoflavones for 12weeks. Cognitive function (spatial working memory, spatial span, pattern recognition memory, 5-choice reaction time, and match to sample visual search) was assessed using CANTAB pre- and post-the 12week intervention. Menopausal symptoms were assessed using Greene’s Climacteric Scale.Results: No significant differences were observed between the groups for any of the cognitive function outcomes measured. Soy drink consumption had no effect on menopausal symptoms overall; however, when women were stratified according to the severity of vasomotor symptoms (VMS) at baseline, women with more severe symptoms at baseline in the medium group had a significant reduction (P = 0.001) in VMS post-intervention (mean change from baseline score: − 2.15 ± 1.73) in comparison to those with less severe VMS (mean change from baseline score: 0.06 ± 1.21).Conclusions: Soy drink consumption had no effect on cognitive function in post-menopausal women. Consumption of ~ 350ml/day (35mg IFs) for 12weeks significantly reduced VMS in those with more severe symptoms at baseline. This finding is clinically relevant as soy drinks may provide an alternative, natural, treatment for alleviating VMS, highly prevalent among western women

KW - CANTAB

KW - Equol

KW - Hot flash

KW - Hot flush

KW - Isoflavones

KW - Menopausal symptoms

UR - http://www.scopus.com/inward/record.url?scp=85062994904&partnerID=8YFLogxK

UR - https://pure.ulster.ac.uk/en/publications/consumption-of-a-soy-drink-has-no-effect-on-cognitive-function-bu

U2 - 10.1007/s00394-019-01942-5

DO - 10.1007/s00394-019-01942-5

M3 - Article

JO - European Journal of Nutrition

T2 - European Journal of Nutrition

JF - European Journal of Nutrition

SN - 1436-6207

ER -