Construction of Multiple Logic Circuits Based on Allosteric DNAzymes

Xin Liu, Qiang Zhang, Xun Zhang, Yuan Liu, Yao Yao, Nikola Kasabov

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Abstract

In DNA computing, the implementation of complex and stable logic operations in a universal system is a critical challenge. It is necessary to develop a system with complex logic functions based on a simple mechanism. Here, the strategy to control the secondary structure of assembled DNAzymes’ conserved domain is adopted to regulate the activity of DNAzymes and avoid the generation of four-way junctions, and makes it possible to implement basic logic gates and their cascade circuits in the same system. In addition, the purpose of threshold control achieved by the allosteric secondary structure implements a three-input DNA voter with one-vote veto function. The scalability of the system can be remarkably improved by adjusting the threshold to implement a DNA voter with 2n + 1 inputs. The proposed strategy provides a feasible idea for constructing more complex DNA circuits and a highly integrated computing system.
Original languageEnglish
Article number495
JournalBiomolecules
Volume12
Issue number4
Early online date24 Mar 2022
DOIs
Publication statusE-pub ahead of print - 24 Mar 2022

Keywords

  • DNA computing
  • allosteric DNAzymes
  • logic circuits
  • threshold control
  • strand displacement

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