Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

Colleen M McDowell; Krishnakumar Kizhatil; Michael H Elliott; Darryl R Overby; Joseph van Batenburg-Sherwood; J Cameron Millar; Markus H Kuehn; Gulab Zode; Ted S Acott; Michael G Anderson; Sanjoy K Bhattacharya; Jacques A Bertrand; Terete Borras; Diane E Bovenkamp; Lin Cheng; John Danias; Michael Lucio De Ieso; Yiqin Du; Jennifer A Faralli; Rudolf Fuchshofer; Preethi S Ganapathy; Haiyan Gong; Samuel Herberg; Humberto Hernandez; Peter Humphries; Simon W M John; Paul L Kaufman; Kate E Keller; Mary J Kelley; Ruth A Kelly; David Krizaj; Ajay Kumar; Brian C Leonard; Raquel L Lieberman; Paloma Liton; Yutao Liu; Katy C Liu; Navita N Lopez; Weiming Mao; Timur Mavlyutov; Fiona McDonnell; Gillian J McLellan; Philip Mzyk; Andrews Nartey; Louis R Pasquale; Gaurang C Patel; Padmanabhan P Pattabiraman; Donna M Peters; Vijaykrishna Raghunathan; Colin E Willoughby

doi:10.1167/iovs.63.2.12

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

Colleen M McDowell
, Krishnakumar Kizhatil
, Michael H Elliott
, Darryl R Overby
, Joseph van Batenburg-Sherwood
, J Cameron Millar
, Markus H Kuehn
, Gulab Zode
, Ted S Acott
, Michael G Anderson
, Sanjoy K Bhattacharya
, Jacques A Bertrand
, Terete Borras
, Diane E Bovenkamp
, Lin Cheng
, John Danias
, Michael Lucio De Ieso
, Yiqin Du
, Jennifer A Faralli
, Rudolf Fuchshofer

Preethi S Ganapathy, Haiyan Gong, Samuel Herberg, Humberto Hernandez, Peter Humphries, Simon W M John, Paul L Kaufman, Kate E Keller, Mary J Kelley, Ruth A Kelly, David Krizaj, Ajay Kumar, Brian C Leonard, Raquel L Lieberman, Paloma Liton, Yutao Liu, Katy C Liu, Navita N Lopez, Weiming Mao, Timur Mavlyutov, Fiona McDonnell, Gillian J McLellan, Philip Mzyk, Andrews Nartey, Louis R Pasquale, Gaurang C Patel, Padmanabhan P Pattabiraman, Donna M Peters, Vijaykrishna Raghunathan, Colin E Willoughby

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171 Downloads (Pure)

Abstract

Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build upon previous findings.

Original language	English
Article number	12
Pages (from-to)	1-17
Number of pages	17
Journal	INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Volume	63
Issue number	2
DOIs	https://doi.org/10.1167/iovs.63.2.12
Publication status	Published (in print/issue) - 7 Feb 2022

Bibliographical note

Funding Information:
The authors thank Aerie Pharmaceuticals, Inc.; Aerpio Pharmaceuticals, Inc.; Allergan; Bausch + Lomb; BrightFocus Foundation; Glaucoma Research Foundation; Glaukonix, Inc.; Glaukos Corp.; Nicox Visible Science; Novartis Pharmaceuticals, Inc.; Regeneron Pharmaceuticals; Santen, Inc.; and the Western Glaucoma Foundation for continued support of the trabecular meshwork study club, enabling 20 annual scientific gatherings of researchers dedicated to better understanding trabecular meshwork biology and facilitating the assembly of this position paper. The authors also thank BrightFocus Foundation for supporting the virtual trabecular meshwork study club meeting to enable continuous discussion among researchers throughout the COVID-19 pandemic. The contents of this manuscript do not represent the views of the U.S. Department of Veterans Affairs or the U.S. Government.

Publisher Copyright:
Copyright 2022 The Authors

Funding

Funding Information: The authors thank Aerie Pharmaceuticals, Inc.; Aerpio Pharmaceuticals, Inc.; Allergan; Bausch + Lomb; BrightFocus Foundation; Glaucoma Research Foundation; Glaukonix, Inc.; Glaukos Corp.; Nicox Visible Science; Novartis Pharmaceuticals, Inc.; Regeneron Pharmaceuticals; Santen, Inc.; and the Western Glaucoma Foundation for continued support of the trabecular meshwork study club, enabling 20 annual scientific gatherings of researchers dedicated to better understanding trabecular meshwork biology and facilitating the assembly of this position paper. The authors also thank BrightFocus Foundation for supporting the virtual trabecular meshwork study club meeting to enable continuous discussion among researchers throughout the COVID-19 pandemic. The contents of this manuscript do not represent the views of the U.S. Department of Veterans Affairs or the U.S. Government. Publisher Copyright: Copyright 2022 The Authors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

mouse model
conventional outflow
glaucoma
intraocular pressure
ocular hypertension
outflow facility
Glaucoma
Conventional outflow
Ocular hypertension
Mouse model
Outflow facility
Intraocular pressure
Ocular Hypertension/metabolism
Trabecular Meshwork/metabolism
Consensus
Animals
Intraocular Pressure/physiology
Aqueous Humor/physiology
Tonometry, Ocular
Mice
Glaucoma/metabolism
Disease Models, Animal

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10.1167/iovs.63.2.12Licence: CC BY

i1552-5783-63-2-12_1644232118.02063Final published version, 2.76 MBLicence: CC BY

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McDowell, C. M., Kizhatil, K., Elliott, M. H., Overby, D. R., van Batenburg-Sherwood, J., Millar, J. C., Kuehn, M. H., Zode, G., Acott, T. S., Anderson, M. G., Bhattacharya, S. K., Bertrand, J. A., Borras, T., Bovenkamp, D. E., Cheng, L., Danias, J., De Ieso, M. L., Du, Y., Faralli, J. A., ... Willoughby, C. E. (2022). Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 63(2), 1-17. Article 12. https://doi.org/10.1167/iovs.63.2.12

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title = "Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms",

abstract = "Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build upon previous findings.",

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author = "McDowell, \{Colleen M\} and Krishnakumar Kizhatil and Elliott, \{Michael H\} and Overby, \{Darryl R\} and \{van Batenburg-Sherwood\}, Joseph and Millar, \{J Cameron\} and Kuehn, \{Markus H\} and Gulab Zode and Acott, \{Ted S\} and Anderson, \{Michael G\} and Bhattacharya, \{Sanjoy K\} and Bertrand, \{Jacques A\} and Terete Borras and Bovenkamp, \{Diane E\} and Lin Cheng and John Danias and \{De Ieso\}, \{Michael Lucio\} and Yiqin Du and Faralli, \{Jennifer A\} and Rudolf Fuchshofer and Ganapathy, \{Preethi S\} and Haiyan Gong and Samuel Herberg and Humberto Hernandez and Peter Humphries and John, \{Simon W M\} and Kaufman, \{Paul L\} and Keller, \{Kate E\} and Kelley, \{Mary J\} and Kelly, \{Ruth A\} and David Krizaj and Ajay Kumar and Leonard, \{Brian C\} and Lieberman, \{Raquel L\} and Paloma Liton and Yutao Liu and Liu, \{Katy C\} and Lopez, \{Navita N\} and Weiming Mao and Timur Mavlyutov and Fiona McDonnell and McLellan, \{Gillian J\} and Philip Mzyk and Andrews Nartey and Pasquale, \{Louis R\} and Patel, \{Gaurang C\} and Pattabiraman, \{Padmanabhan P\} and Peters, \{Donna M\} and Vijaykrishna Raghunathan and Willoughby, \{Colin E\}",

note = "Funding Information: The authors thank Aerie Pharmaceuticals, Inc.; Aerpio Pharmaceuticals, Inc.; Allergan; Bausch + Lomb; BrightFocus Foundation; Glaucoma Research Foundation; Glaukonix, Inc.; Glaukos Corp.; Nicox Visible Science; Novartis Pharmaceuticals, Inc.; Regeneron Pharmaceuticals; Santen, Inc.; and the Western Glaucoma Foundation for continued support of the trabecular meshwork study club, enabling 20 annual scientific gatherings of researchers dedicated to better understanding trabecular meshwork biology and facilitating the assembly of this position paper. The authors also thank BrightFocus Foundation for supporting the virtual trabecular meshwork study club meeting to enable continuous discussion among researchers throughout the COVID-19 pandemic. The contents of this manuscript do not represent the views of the U.S. Department of Veterans Affairs or the U.S. Government. Publisher Copyright: Copyright 2022 The Authors",

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month = feb,

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doi = "10.1167/iovs.63.2.12",

language = "English",

volume = "63",

pages = "1--17",

journal = "INVESTIGATIVE OPHTHALMOLOGY \& VISUAL SCIENCE",

issn = "0146-0404",

publisher = "Association for Research in Vision and Ophthalmology Inc.",

number = "2",

}

McDowell, CM, Kizhatil, K, Elliott, MH, Overby, DR, van Batenburg-Sherwood, J, Millar, JC, Kuehn, MH, Zode, G, Acott, TS, Anderson, MG, Bhattacharya, SK, Bertrand, JA, Borras, T, Bovenkamp, DE, Cheng, L, Danias, J, De Ieso, ML, Du, Y, Faralli, JA, Fuchshofer, R, Ganapathy, PS, Gong, H, Herberg, S, Hernandez, H, Humphries, P, John, SWM, Kaufman, PL, Keller, KE, Kelley, MJ, Kelly, RA, Krizaj, D, Kumar, A, Leonard, BC, Lieberman, RL, Liton, P, Liu, Y, Liu, KC, Lopez, NN, Mao, W, Mavlyutov, T, McDonnell, F, McLellan, GJ, Mzyk, P, Nartey, A, Pasquale, LR, Patel, GC, Pattabiraman, PP, Peters, DM, Raghunathan, V & Willoughby, CE 2022, 'Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms', INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 63, no. 2, 12, pp. 1-17. https://doi.org/10.1167/iovs.63.2.12

TY - JOUR

T1 - Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

AU - McDowell, Colleen M

AU - Kizhatil, Krishnakumar

AU - Elliott, Michael H

AU - Overby, Darryl R

AU - van Batenburg-Sherwood, Joseph

AU - Millar, J Cameron

AU - Kuehn, Markus H

AU - Zode, Gulab

AU - Acott, Ted S

AU - Anderson, Michael G

AU - Bhattacharya, Sanjoy K

AU - Bertrand, Jacques A

AU - Borras, Terete

AU - Bovenkamp, Diane E

AU - Cheng, Lin

AU - Danias, John

AU - De Ieso, Michael Lucio

AU - Du, Yiqin

AU - Faralli, Jennifer A

AU - Fuchshofer, Rudolf

AU - Ganapathy, Preethi S

AU - Gong, Haiyan

AU - Herberg, Samuel

AU - Hernandez, Humberto

AU - Humphries, Peter

AU - John, Simon W M

AU - Kaufman, Paul L

AU - Keller, Kate E

AU - Kelley, Mary J

AU - Kelly, Ruth A

AU - Krizaj, David

AU - Kumar, Ajay

AU - Leonard, Brian C

AU - Lieberman, Raquel L

AU - Liton, Paloma

AU - Liu, Yutao

AU - Liu, Katy C

AU - Lopez, Navita N

AU - Mao, Weiming

AU - Mavlyutov, Timur

AU - McDonnell, Fiona

AU - McLellan, Gillian J

AU - Mzyk, Philip

AU - Nartey, Andrews

AU - Pasquale, Louis R

AU - Patel, Gaurang C

AU - Pattabiraman, Padmanabhan P

AU - Peters, Donna M

AU - Raghunathan, Vijaykrishna

AU - Willoughby, Colin E

N1 - Funding Information: The authors thank Aerie Pharmaceuticals, Inc.; Aerpio Pharmaceuticals, Inc.; Allergan; Bausch + Lomb; BrightFocus Foundation; Glaucoma Research Foundation; Glaukonix, Inc.; Glaukos Corp.; Nicox Visible Science; Novartis Pharmaceuticals, Inc.; Regeneron Pharmaceuticals; Santen, Inc.; and the Western Glaucoma Foundation for continued support of the trabecular meshwork study club, enabling 20 annual scientific gatherings of researchers dedicated to better understanding trabecular meshwork biology and facilitating the assembly of this position paper. The authors also thank BrightFocus Foundation for supporting the virtual trabecular meshwork study club meeting to enable continuous discussion among researchers throughout the COVID-19 pandemic. The contents of this manuscript do not represent the views of the U.S. Department of Veterans Affairs or the U.S. Government. Publisher Copyright: Copyright 2022 The Authors

PY - 2022/2/7

Y1 - 2022/2/7

N2 - Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build upon previous findings.

AB - Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build upon previous findings.

KW - mouse model

KW - conventional outflow

KW - glaucoma

KW - intraocular pressure

KW - ocular hypertension

KW - outflow facility

KW - Glaucoma

KW - Conventional outflow

KW - Ocular hypertension

KW - Mouse model

KW - Outflow facility

KW - Intraocular pressure

KW - Ocular Hypertension/metabolism

KW - Trabecular Meshwork/metabolism

KW - Consensus

KW - Animals

KW - Intraocular Pressure/physiology

KW - Aqueous Humor/physiology

KW - Tonometry, Ocular

KW - Mice

KW - Glaucoma/metabolism

KW - Disease Models, Animal

UR - https://www.scopus.com/pages/publications/85124219559

U2 - 10.1167/iovs.63.2.12

DO - 10.1167/iovs.63.2.12

M3 - Article

C2 - 35129590

SN - 0146-0404

VL - 63

SP - 1

EP - 17

JO - INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

JF - INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

IS - 2

M1 - 12

ER -

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

Access to Document

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